公开(公告)号：US20250017883A1

公开(公告)日：2025-01-16

申请号：US18901917

申请日：2024-09-30

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Alla ARZUMANYAN ,  Ira C. Spector ,  Mark A. Feitelson

IPC: A61K31/19 ,  A61K9/00 ,  A61K9/48 ,  A61K45/06 ,  A61P17/00 ,  A61P27/02 ,  A61P35/00 ,  A61P37/08

Abstract: The invention relates to compositions and methods that include short chain fatty acids (SCFAs), related therapeutic compounds, and other compounds, including combinations thereof, for the treatment or prevention of diseases or disorders.

公开(公告)号：US20250001014A1

公开(公告)日：2025-01-02

申请号：US18736260

申请日：2024-06-06

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. FELDMAN ,  Joseph Y. CHEUNG

IPC: A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C07K19/00 ,  C12N15/113 ,  C12N15/85

Abstract: The present invention features methods and compositions for treatment of heart failure. The compositions can include an isolated nucleic acid encoding a BAG3 polypeptide or fragment thereof.

公开(公告)号：US12122997B2

公开(公告)日：2024-10-22

申请号：US15998558

申请日：2017-02-13

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Kamel Khalili ,  Wenhui Hu

IPC: C12N15/11 ,  A61K48/00 ,  C12N9/22 ,  C12N15/113

CPC classification number: C12N15/11 ,  A61K48/00 ,  C12N9/22 ,  C12N15/1132 ,  A01K2227/105 ,  A01K2267/0337 ,  C07K2319/09 ,  C12N2310/20 ,  C12N2750/14143

Abstract: Compositions for the in vivo delivery of a gene editing CRISPR/Cas9 complex was developed to eliminate integrated retroviral DNA sequences from latently infected human cells and animal disease models.

公开(公告)号：US12091814B2

公开(公告)日：2024-09-17

申请号：US16767496

申请日：2018-11-29

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Shenqiang Ren ,  Simona Percec ,  Zhuolei Zhang

IPC: C23C16/00 ,  C23C16/40 ,  C23C18/12 ,  D06M11/45 ,  D06M11/55 ,  D06M11/79 ,  D06M101/36

CPC classification number: D06M11/45 ,  C23C16/403 ,  C23C18/122 ,  C23C18/1254 ,  D06M11/55 ,  D06M11/79 ,  D06M2101/36 ,  D06M2400/02

Abstract: The present invention relates in part to a method of fabricating a ceramic-polymer composite by contacting a polymer material with an acid solution and depositing a ceramic on the polymer material. The invention also relates in part to ceramic-polymer composites produced using said method and ballistic resistant materials comprising said ceramic-polymer composites.

公开(公告)号：US20240274874A1

公开(公告)日：2024-08-15

申请号：US18591852

申请日：2024-02-29

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Mike Zdilla ,  Stephanie Wunder

IPC: H01M10/0565 ,  H01M10/052

CPC classification number: H01M10/0565 ,  H01M10/052 ,  H01M2300/0082

Abstract: The invention provides a novel anionic polymer useful as a solid electrolyte in a lithium battery. The electrolyte matrix provides directional, flexible, polymeric ion channels with 100% lithium conduction with low-to-no affinity of the matrix for the lithium ion, in part due to the low concentration or absence of lone pair electrons in the anionic polymer.

公开(公告)号：US20240246904A1

公开(公告)日：2024-07-25

申请号：US18413255

申请日：2024-01-16

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Magid A. Abou-Gharbia ,  Wayne E. Childers ,  Marlene A. Jacobson ,  Rong Fan ,  Rogelio L. Martinez

IPC: C07C255/50 ,  A61K9/00 ,  A61P3/00 ,  A61P33/00 ,  C07C217/18 ,  C07C217/48

CPC classification number: C07C255/50 ,  A61K9/0053 ,  A61P3/00 ,  A61P33/00 ,  C07C217/18 ,  C07C217/48

Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.

公开(公告)号：US20240158811A1

公开(公告)日：2024-05-16

申请号：US18549948

申请日：2022-03-11

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： SHUXIN Li

IPC: C12N15/86 ,  A61K48/00 ,  C07K14/005

CPC classification number: C12N15/86 ,  A61K48/0058 ,  C07K14/005 ,  C12N2310/113 ,  C12N2310/13 ,  C12N2750/14143 ,  C12N2830/008

Abstract: The present invention generally relates to engineered adeno-associated viral (AAV) vectors capable of traversing the blood-brain barrier and transducing specific neural cells with high efficiency. The present invention also relates to methods of producing engineered AAV vectors and treating diseases and disorders associated with neural cell damage and degeneration.

公开(公告)号：US20240132698A1

公开(公告)日：2024-04-25

申请号：US18356755

申请日：2023-07-21

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Shenqiang Ren ,  Simona Percec ,  Zhuolei Zhang

IPC: C08K3/38 ,  B29B7/90 ,  B29C41/00 ,  B29C55/00 ,  B29C55/04 ,  B29C55/18 ,  C08F110/02 ,  C08J3/21 ,  C08K7/00 ,  F41H5/04

CPC classification number: C08K3/38 ,  B29B7/90 ,  B29C41/006 ,  B29C55/005 ,  B29C55/04 ,  B29C55/18 ,  C08F110/02 ,  C08J3/212 ,  C08K7/00 ,  F41H5/0485 ,  B29K2507/04

Abstract: A method of fabricating a polymer composite material by mixing a polymer material with a planar material, depositing the mixture on a substrate, and stretching the resulting thin film, is described. Polymer composite materials produced using said method and ballistic resistant materials comprising said polymer composite materials are also described.

公开(公告)号：US20240058310A1

公开(公告)日：2024-02-22

申请号：US18329957

申请日：2023-06-06

Applicant: Temple University-Of the Commonwealth System of Higher Education

Inventor： Jonathan Soboloff ,  M. Raza Zaidi ,  Scott Gross ,  John Elrod

IPC: A61K31/426 ,  A61P35/04

CPC classification number: A61K31/426 ,  A61P35/04

Abstract: The invention comprises methods for treating diseases or disorders associated with reduced levels of Ca2+ signaling, including melanoma and other cancers.

公开(公告)号：US20240009155A1

公开(公告)日：2024-01-11

申请号：US18252222

申请日：2021-11-12

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Mark A. Feitelson ,  Alla Arzumanyan ,  Ira Spector

IPC: A61K31/19 ,  A61P35/00 ,  A61K33/08

CPC classification number: A61K31/19 ,  A61P35/00 ,  A61K33/08

Abstract: The present disclosure describes compositions and methods for treating hepatitis B virus-associated hepatocellular carcinoma. Chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). The HBV encoded oncoprotein, HBx, alters the expression of host genes and the activity of multiple signal transduction pathways. Short chain fatty acids can be used to delay or block the progression of chronic liver disease to HCC by targeting functions associated with HBx.