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    External fixation assembly and method of use
    173.
    发明授权
    External fixation assembly and method of use 有权
    外固定装配及使用方法

    公开(公告)号：US09050136B2

    公开(公告)日：2015-06-09

    申请号：US13896750

    申请日：2013-05-17

    Applicant: Wake Forest University Health Sciences

    Inventor： Lawrence X Webb ,  Louis C Argenta ,  Michael J Morykwas

    IPC: A61F5/04 ,  A61B17/60 ,  A61B17/66 ,  A61B17/86 ,  A61B17/00

    CPC classification number: A61B17/66 ,  A61B17/60 ,  A61B17/864 ,  A61B17/866 ,  A61B17/8685 ,  A61B2017/00544

    Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.

    Abstract translation: 外部固定组件包括插入患者骨骼中的多个中空销。 每个销具有内孔和从孔延伸穿过销壁延伸的多个孔。 销可以联接到真空压力源，可操作以在围绕销的组织中产生减小的压力。 一个盖被放置在销的周围并被密封以提供一个流体密封的外壳，其保持围绕销的减压。 使用上述固定销来施加外部固定的方法包括以下步骤：将每个销插入皮肤开口，将销孔定位在所选组织附近，用密封的外壳覆盖皮肤开口，将销连接到真空压力源 并且激活真空压力源以在患者的组织中在骨骼处或骨附近产生减压。

    TOPICAL WOUND TREATMENT METHOD AND COMPOSITION
    175.
    发明申请
    TOPICAL WOUND TREATMENT METHOD AND COMPOSITION 审中-公开
    主题治疗方法与组合

    公开(公告)号：US20150024053A1

    公开(公告)日：2015-01-22

    申请号：US14382175

    申请日：2013-03-01

    Applicant: Wake Forest University Health Sciences

    Inventor： Benjamin S. Harrison ,  Steve J. Hodges

    IPC: A61K9/00 ,  A61K9/14 ,  A61J1/05 ,  A61K47/02 ,  A61K31/17 ,  A61K45/06 ,  A61K47/10

    CPC classification number: A61K9/0014 ,  A61J1/05 ,  A61K9/06 ,  A61K9/14 ,  A61K31/17 ,  A61K31/327 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/44 ,  A61M5/178 ,  A61K2300/00

    Abstract: A topical wound treatment composition comprises a hydrogen peroxide generator; alkaline powder; not more than 5 percent by weight of water; additional topical active agent if desired, and emollient (preferably hygroscopic emollient) to balance. When topically applied to a wound and water from the surrounding environment diffuses into the composition, the hydrogen peroxide generator and/or the alkaline compound diffuse into one another, causing a chemical reaction that generates treatment-effective amounts of oxygen to occur. The oxygen can then diffuse out of the composition and aid in wound treatment or healing.

    Abstract translation: 局部伤口治疗组合物包含过氧化氢发生器; 碱性粉末; 不超过5重量％的水; 如果需要，还可使用额外的局部活性剂，以及平衡润肤剂（优选吸湿性润肤剂）。 当局部施用于伤口并且周围环境的水扩散到组合物中时，过氧化氢发生器和/或碱性化合物彼此扩散，引起产生治疗有效量的氧气的化学反应。 然后，氧气可以扩散出组合物，有助于伤口治疗或愈合。

    Methods for Identifying and Treating an Individual with an Inflammatory Disease using Fatty Acid-Based Therapies
    176.
    发明申请
    Methods for Identifying and Treating an Individual with an Inflammatory Disease using Fatty Acid-Based Therapies 审中-公开
    使用基于脂肪酸的疗法鉴别和治疗患有炎症疾病的个体的方法

    公开(公告)号：US20150005382A1

    公开(公告)日：2015-01-01

    申请号：US14367158

    申请日：2012-10-04

    Applicant: Wake Forest University Health Sciences (WFUHS)

    Inventor： Floyd H. Chilton

    IPC: C12Q1/68 ,  A61K36/30 ,  A61K31/202

    CPC classification number: C12Q1/6883 ,  A61K31/202 ,  A61K36/30 ,  C12Q2600/106 ,  C12Q2600/156

    Abstract: The present invention provides methods of identifying a subject as responsive to treatment of an inflammatory disease and/or inflammation with one or more polyunsaturated fatty acids (PUFAs), comprising detecting, in a nucleic acid sample of a subject having an inflammatory disease and/or inflammation, the presence of a C allele at single nucleotide polymorphism (SNP) rs730012 in the leukotriene C4 synthase gene, wherein the presence of said C allele at rs730012 in said nucleic acid sample from the subject indicates that the subject is responsive to treatment of said inflammatory disease and/or inflammation with one or more PUFAs.

    Abstract translation: 本发明提供了鉴定受试者响应于用一种或多种多不饱和脂肪酸（PUFA）治疗炎性疾病和/或炎症的方法，包括在具有炎性疾病和/或感染的受试者的核酸样品中检测 炎症，在白细胞三烯C4合酶基因中存在单核苷酸多态性（SNP）rs730012处的C等位基因，其中在来自受试者的所述核酸样品中rs730012处的所述C等位基因的存在表明受试者对所述 炎性疾病和/或炎症与一种或多种PUFA。

    MEX3C REGULATION AND TARGET TO CONTROL OBESITY AND DIABETES
    177.
    发明申请
    MEX3C REGULATION AND TARGET TO CONTROL OBESITY AND DIABETES 审中-公开
    MEX3C规范和目标来控制肥胖和糖尿病

    公开(公告)号：US20140363380A1

    公开(公告)日：2014-12-11

    申请号：US14212715

    申请日：2014-03-14

    Applicant: Wake Forest University Health Sciences

    Inventor： Baisong Lu ,  Colin E. Bishop

    IPC: A61K49/00 ,  G01N30/00 ,  G01N21/25 ,  A61K31/713 ,  G01N33/68

    CPC classification number: A61K49/0008 ,  A61K31/713 ,  G01N21/25 ,  G01N30/00 ,  G01N33/5023 ,  G01N33/6893 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/044

    Abstract: MEX3C deficiency impairs the development of white and brown adipose tissue. Hence the present invention provides, among other things, a method of screening a candidate compound for activity in inhibiting fat deposition in a subject in need thereof and/or treating a condition in a subject in need thereof, comprising: (a) contacting a candidate compound to a cell that expresses MEX3C protein; and then (b) detecting a quantity of expression of the MEX3C protein in the cell; a depression in the expression of MEX3C protein when the candidate compound is contacted thereto as compared to that expressed when the candidate compound is not contacted thereto indicating the compound is active in inhibiting fat deposition and/or treating a condition in a subject in need thereof. Methods of treatment and screening subjects are also described.

    Abstract translation: MEX3C缺乏会损害白色和棕色脂肪组织的发育。 因此，本发明尤其提供了筛选候选化合物以抑制有需要的受试者中的脂肪沉积的活性的方法和/或治疗有需要的受试者的状况，其包括：（a）使候选者 化合物表达MEX3C蛋白的细胞; 然后（b）检测细胞中MEX3C蛋白的表达量; 当候选化合物与其接触时，与候选化合物不接触时所表达的MEX3C蛋白表达的抑制相反，表明该化合物在抑制脂肪沉积和/或治疗有需要的受试者中的病症方面是有活性的。 还描述了治疗和筛选受试者的方法。

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