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    Sulfonamide compound
    11.
    发明授权
    Sulfonamide compound 失效
    磺酰胺化合物

    公开(公告)号：US08415372B2

    公开(公告)日：2013-04-09

    申请号：US12526000

    申请日：2007-02-27

    申请人： Rintaro Yamada ,  Minoru Seto

    发明人： Rintaro Yamada ,  Minoru Seto

    IPC分类号： C07D401/02 ,  A61K31/47

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

    摘要： A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G4 represents hydroxyl group, or —N(R1)(R2) (R1 and R2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, or a saturated heterocyclic group); G5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits Rho kinase.

    摘要翻译： 由式（1）表示的化合物[A表示含氮饱和环; m表示0〜2的整数。 n表示1〜4的整数， G1表示氢原子，氯原子，羟基，烷氧基或氨基; G 2表示卤素原子，羟基，氰基，羧基，烷基，烯基等; G3表示氢原子，卤素原子，羟基，氰基，羧基，烷基，烯基等; G4表示羟基或-N（R1）（R2）（R1和R2表示氢原子，烷基，芳烷基，烯基，炔基或饱和杂环基）。 G5是A的环构成碳原子上的取代基，代表氢原子，氟原子或烷基，或其盐，或其作为前体药物的衍生物，其有效抑制Rho激酶。

    Method for stabilizing leuco-type colorant
    13.
    发明授权
    Method for stabilizing leuco-type colorant 有权
    稳定无色型着色剂的方法

    公开(公告)号：US08268017B2

    公开(公告)日：2012-09-18

    申请号：US12034793

    申请日：2008-02-21

    申请人： Shigeru Ueda ,  Takeshi Matsuoka ,  Akihiko Kan

    发明人： Shigeru Ueda ,  Takeshi Matsuoka ,  Akihiko Kan

    IPC分类号： C09B67/00 ,  D06P5/00 ,  G01N33/72 ,  G03C8/00 ,  C08B37/16 ,  C12N9/00 ,  C12Q1/00 ,  C12Q1/37 ,  C12Q1/26

    CPC分类号： C12Q1/28 ,  C09B67/0077

    摘要： Provided are a method of stabilizing a leuco dye storable as a liquid for a long time, a method of reducing nonspecific color development thereof at a time of a color development reaction, and a stable liquid reagent composition using the methods. The inventors of the present invention found that coexistence of the leuco dye with a specific reducing agent resulted in suppression of self color development and its remarkably improved stability in a solution, and that when a color development reaction of the leuco dye with hydrogen peroxide was performed, coexistence of the leuco dye, in a reaction solution, with another dye which had an absorption spectrum not influencing a measurement wavelength of the leuco dye and did not react with hydrogen peroxide suppressed nonspecific color development and lowered a reagent blank value, which was applied to an analytical reagent.

    摘要翻译： 提供一种稳定长时间保存为液体的无色染料的方法，在显色反应时减少其非特异性显色的方法和使用该方法的稳定的液体试剂组合物。 本发明人发现，无色染料与特定的还原剂共存导致自色显影的抑制和其在溶液中的显着提高的稳定性，并且当进行无色染料与过氧化氢的显色反应时 在无色染料的反应溶液中与另一种不影响无色染料的测定波长的吸收光谱并且不与过氧化氢反应的染料共存抑制非特异性显色，降低试剂空白值 分析试剂。

    METHOD AND REAGENT FOR MEASURING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL COENZYME A, AND COENZYME A
    14.
    发明申请
    METHOD AND REAGENT FOR MEASURING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL COENZYME A, AND COENZYME A 审中-公开
    用于测量甲酸，3-羟基甲基胆碱酯酶A和COENZYME A的方法和试剂

    公开(公告)号：US20120040387A1

    公开(公告)日：2012-02-16

    申请号：US13144710

    申请日：2009-01-19

    申请人： Takeshi Matsuoka

    发明人： Takeshi Matsuoka

    IPC分类号： C12Q1/26 ,  C07C59/105 ,  C12N9/04 ,  C12Q1/48 ,  C12N1/20

    CPC分类号： C12Q1/008 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1205 ,  C12Q1/26 ,  C12R1/01 ,  C12R1/38 ,  G01N33/5308 ,  G01N2333/904

    摘要： The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that catalyzes a reaction represented by Reaction Formula 1 and an enzyme that catalyzes a reaction represented by Reaction Formula 2 to act on a test solution containing mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A in the presence of a hydrogen acceptor X, a hydrogen donor Y, and coenzyme A; and (q) a step of measuring an amount of: a reduced hydrogen acceptor X that is produced; or an oxidized hydrogen donor Y that is produced; or a hydrogen acceptor X that is decreased; or a hydrogen donor Y that is decreased, wherein the hydrogen donor Y and the reduced hydrogen acceptor X are not the same.

    摘要翻译： 本发明提供了一种用于测量测试溶液中分析物浓度的方法，其中分析物是甲羟戊酸和/或3-羟甲基戊二酰辅酶A，包括以下步骤（p）和（q）：（p）步骤 允许催化由反应式1表示的反应的酶和催化反应式2表示的反应的酶在氢受体X存在下作用于含有甲羟戊酸和/或3-羟甲基戊二酰辅酶A的试验溶液， 氢供体Y和辅酶A; 和（q）测量生成的还原氢受体X的量的步骤; 或产生的氧化氢供体Y; 或降低的氢受体X; 或降低的氢供体Y，其中氢供体Y和还原氢受体X不相同。

    Method for stabilizing coenzyme and composition therefor
    18.
    发明授权
    Method for stabilizing coenzyme and composition therefor 有权
    稳定辅酶的方法及其组成

    公开(公告)号：US07879567B2

    公开(公告)日：2011-02-01

    申请号：US11576048

    申请日：2005-10-05

    申请人： Fumitomo Odawara

    发明人： Fumitomo Odawara

    IPC分类号： G01N33/53 ,  G01N31/00

    CPC分类号： C07B63/04 ,  C12Q1/008

    摘要： Disclosed is a sugar and/or a sugar alcohol as a substance for suppressing dephosphorylation reaction of a phosphorylated coenzyme. Also disclosed is a method for stabilizing a phosphorylated coenzyme which is characterized by having at least a substance for suppressing dephosphorylation reaction of the phosphorylated coenzyme coexist with the phosphorylated coenzyme.

    摘要翻译： 公开了作为抑制磷酸化辅酶的去磷酸化反应的物质的糖和/或糖醇。 还公开了一种稳定磷酸化辅酶的方法，其特征在于至少具有抑制磷酸化辅酶的去磷酸化反应与磷酸化辅酶共存的物质。

    Crystal of substituted phenylalkanoic acid ester and process for producing the same
    19.
    发明授权
    Crystal of substituted phenylalkanoic acid ester and process for producing the same 有权
    取代苯基链烷酸酯的晶体及其制备方法

    公开(公告)号：US07838546B2

    公开(公告)日：2010-11-23

    申请号：US12788061

    申请日：2010-05-26

    申请人： Motoshi Shoda

    发明人： Motoshi Shoda

    IPC分类号： A61K31/416 ,  C07D231/56

    CPC分类号： C07D231/56

    摘要： In the case of using 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionic acid, methyl 3-[4-(indan-2-yloxy)-3-(1-methyl-1H-indazol-5-yl)-5-nitrophenyl]propionate, or methyl 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionate as a medicine, more preferable aspects or improved methods are provided.Crystals of any compound among 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionic acid, methyl 3-[4-(indan-2-yloxy)-3-(1-methyl-1H-indazol-5-yl)-5-nitrophenyl]propionate, and methyl 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionate, and methods of producing the same are provided.

    摘要翻译： 在使用3- [3-氨基-4-（茚满-2-基氧基）-5-（1-甲基-1H-吲唑-5-基）苯基]丙酸的情况下，使用3- [4-（茚满） -2-氧基）-3-（1-甲基-1H-吲唑-5-基）-5-硝基苯基]丙酸乙酯或3- [3-氨基-4-（茚满-2-基氧基）-5-（ 1-甲基-1H-吲唑-5-基）苯基]丙酸乙酯，更优选的方案或改进的方法。 3- [3-氨基-4-（茚满-2-基氧基）-5-（1-甲基-1H-吲唑-5-基）苯基]丙酸，3- [4-（茚满酮）的任何化合物的晶体 -2-基氧基）-3-（1-甲基-1H-吲唑-5-基）-5-硝基苯基]丙酸甲酯和3- [3-氨基-4-（茚满-2-基氧基）-5-（ 1-甲基-1H-吲唑-5-基）苯基]丙酸乙酯及其制备方法。