利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

36 条记录 (耗时 0.025 秒)

    Capsule rectification apparatus
    11.
    发明授权
    Capsule rectification apparatus 失效
    胶囊整流装置

    公开(公告)号：US4828142A

    公开(公告)日：1989-05-09

    申请号：US82308

    申请日：1987-08-06

    申请人： Hugh P. McKnight

    发明人： Hugh P. McKnight

    IPC分类号： A61J3/07

    CPC分类号： A61J3/074

    摘要： An apparatus for handling empty two-piece capsules includes a vertically reciprocating feeder which extracts capsules from a hopper and forms randomly ordered linear arrays. A horizontal row of capsules are fed by the feeder to key-shaped slots in a block below the feeder. A blade reciprocally positioned adjacent the wider portion of the key-shaped slots moves into the slot at about the middle of the capsule to turn the capsules so as to be partly positioned within the narrower portion of the key-shaped slot. Each capsule is then ejected by projectable pins into a channel where the capsules are pneumatically accelerated into a pair of mated receiving rings which separate the two halves of the capsule.

    摘要翻译： 用于处理空的两件式胶囊的装置包括垂直往复式进料器，其从料斗中提取胶囊并形成随机排列的线性阵列。 一个水平排的胶囊由进料器供给到进料器下面一个块中的键形槽。 相邻于键状槽的较宽部分相对定位的刀片在胶囊的中部附近移动到狭槽中，以使胶囊转动以部分地位于钥匙形槽的较窄部分内。 然后将每个胶囊通过可投射销喷射到通道中，其中胶囊被气动加速成一对分开胶囊的两半的配合的接收环。

    Pulsatile delivery of leptin receptor ligands
    15.
    发明授权
    Pulsatile delivery of leptin receptor ligands 失效
    瘦素受体配体的脉冲递送

    公开(公告)号：US5965521A

    公开(公告)日：1999-10-12

    申请号：US804668

    申请日：1997-02-25

    申请人： Thomas W. Stephens ,  Mark L. Heiman ,  Jose F. Caro

    发明人： Thomas W. Stephens ,  Mark L. Heiman ,  Jose F. Caro

    IPC分类号： A61P5/24 ,  A61K38/00 ,  A61K38/22 ,  A61K39/395 ,  A61K45/00 ,  A61P3/04 ,  A61P5/00 ,  A61P5/42 ,  A61K38/24 ,  A01N37/18

    CPC分类号： A61K38/2264

    摘要： This invention provides a method for optimizing the administration of leptin receptor ligands to a mammal in need of such treatment. More specifically, this invention provides an improved method of delivering leptin receptor ligands to a mammal in need of such treatment comprising pulsatile or peak delivery of leptin receptor ligands to treat obesity and related conditions, including hyperglucocorticoidinemia, fertility or delayed puberty, and/or growth hormone deficiencies.

    摘要翻译： 本发明提供了一种用于优化对需要这种治疗的哺乳动物的瘦蛋白受体配体施用的方法。 更具体地，本发明提供了向需要这种治疗的哺乳动物递送瘦蛋白受体配体的改进方法，其包括瘦蛋白受体配体的脉动或峰值递送以治疗肥胖症和相关病症，包括高糖皮质激素血症，生育能力或延迟青春期和/或生长 激素缺乏症。

    Controlled release infusion system
    16.
    发明授权
    Controlled release infusion system 失效
    控制释放输液系统

    公开(公告)号：US4534758A

    公开(公告)日：1985-08-13

    申请号：US514268

    申请日：1983-07-15

    申请人： Michael J. Akers ,  William W. Hargrove ,  Dale C. Harris ,  Charles R. Sperry

    发明人： Michael J. Akers ,  William W. Hargrove ,  Dale C. Harris ,  Charles R. Sperry

    IPC分类号： A61M5/14 ,  A61M5/175 ,  A61M39/22

    CPC分类号： A61M39/223 ,  A61M5/1409 ,  A61M5/162

    摘要： Valved adaptors are disclosed permitting the introduction of a drug-containing vial in the delivery tube of an I.V. administration set. The adaptors have a three position operation characterized by a bypass mode, a dilution mode, and a delivery mode, the adaptors being manually changed from mode to mode. The disclosed adaptors include gravity operated valves, reciprocating spool valves, and rotating spool valves, each including a spike to penetrate the stopper of a vial and a vent to permit air to escape the vial as liquid is introduced to dilute the vial contents.

    摘要翻译： 公开的阀门适配器允许在I.V.的输送管中引入含药物的小瓶。 管理集 适配器具有以旁路模式，稀释模式和传送模式为特征的三位置操作，适配器被手动地从模式改变为模式。 所公开的适配器包括重力操作阀，往复式滑阀和旋转滑阀，每个阀都包括一个尖头，以穿透小瓶的塞子和通气孔，以允许空气在引入液体以稀释小瓶内容物时逃离小瓶。

    MODIFIED VIRAL PARTICLES WITH IMMUNOGENIC PROPERTIES AND REDUCED LIPID CONTENT USEFUL FOR TREATING AND PREVENTING INFECTIOUS DISEASES
    18.
    发明申请
    MODIFIED VIRAL PARTICLES WITH IMMUNOGENIC PROPERTIES AND REDUCED LIPID CONTENT USEFUL FOR TREATING AND PREVENTING INFECTIOUS DISEASES 审中-公开
    具有免疫原性的修饰病毒颗粒和减少脂质含量用于治疗和预防感染性疾病

    公开(公告)号：US20140050763A1

    公开(公告)日：2014-02-20

    申请号：US14067081

    申请日：2013-10-30

    申请人： ELI LILLY & COMPANY

    发明人： BILL E. CHAM ,  JO-ANN B. MALTAIS ,  MARC BELLOTTI ,  ADAM PAUL CONNER ,  HASSIBULLAH AKEEFE ,  MOIZ KITABWALLA

    IPC分类号： A61K39/29 ,  A61K39/12

    CPC分类号： A61K39/292 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/5252 ,  A61K2039/55566 ,  A61K2039/57 ,  A61L2/0011 ,  A61L2/0088 ,  A61M1/3486 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2730/10163 ,  C12N2740/15034 ,  C12N2740/15063 ,  C12N2770/20034 ,  C12N2770/24063 ,  C12N2770/24334 ,  C12N2770/24363

    摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.

    摘要翻译： 本发明涉及一种减少感染性疾病，特别是感染性疾病的发生和严重性的方法，其中在生物流体例如血液中发现含有脂质的感染性病毒生物。 本发明使用可用于从含脂质感染性病毒生物体提取脂质的溶剂，从而产生具有降低的感染性和增强的抗原性的改性病毒颗粒。 本发明提供疫苗组合物，其包含具有降低的感染性和增强的抗原性的这些经修饰的病毒颗粒，任选与药学上可接受的载体或免疫刺激剂组合。 将疫苗组合物施用于患者以提供针对含脂质感染性病毒生物体的保护。 本发明的疫苗组合物包括由一种或多种病毒株和/或一种或多种病毒获得的经修饰的病毒颗粒的组合疫苗。