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    VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT
    12.
    发明申请
    VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT 审中-公开
    含有合成添加剂的疫苗组合物

    公开(公告)号：US20110070290A1

    公开(公告)日：2011-03-24

    申请号：US12843398

    申请日：2010-07-26

    申请人： Steven G. Reed ,  Darrick Carter

    发明人： Steven G. Reed ,  Darrick Carter

    IPC分类号： A61K39/155 ,  A61K9/127 ,  A61K9/107 ,  A61P11/08 ,  A61P37/04

    CPC分类号： A61K39/39 ,  A61K39/0005 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  Y02A50/41 ,  Y02A50/412

    摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

    摘要翻译： 基于在基本上均匀形式提供的合成的吡喃葡萄糖基脂质佐剂（GLA）中发现有用的免疫佐剂性质，公开了组合物和方法，包括用于诱导或增强免疫应答的疫苗和药物组合物。 在化学上，合成的GLA提供了从批次到批次的一致的疫苗组分，而不会损害天然产物佐剂的污染物或活性的波动。 还提供了疫苗和药物组合物，其包括GLA和抗原，Toll样受体（TLR）激动剂，辅助佐剂和载体如药物载体中的一种或多种。

    Compounds and Methods for Diagnosis and Treatment of Leishmaniasis
    17.
    发明申请
    Compounds and Methods for Diagnosis and Treatment of Leishmaniasis 有权
    利什曼病诊断和治疗的化合物和方法

    公开(公告)号：US20070237794A1

    公开(公告)日：2007-10-11

    申请号：US11733440

    申请日：2007-04-10

    申请人： Yasuyuki Goto ,  Steven Reed

    发明人： Yasuyuki Goto ,  Steven Reed

    IPC分类号： A61K39/00 ,  G01N33/569 ,  C07H21/04 ,  C12P21/06 ,  C12N1/10 ,  C07K14/44 ,  C12N15/74

    CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

    摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

    摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。