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    Chromobacterium Subtsugae Genome
    11.
    发明申请
    Chromobacterium Subtsugae Genome 有权

    公开(公告)号：US20210388378A1

    公开(公告)日：2021-12-16

    申请号：US17409198

    申请日：2021-08-23

    申请人： MARRONE BIO INNOVATIONS, INC.

    发明人： Ana Lucia Cordova-Kreylos ,  Debora Wilk ,  Pamela G. Marrone

    IPC分类号： C12N15/82 ,  C12N9/42 ,  C12N9/52 ,  A01N37/46 ,  C07K14/42 ,  A01N63/20 ,  A01N63/50 ,  C12N9/24

    摘要： Disclosed herein is the nucleotide sequence of the Chromobacterium subtsugae genome. Also provided are the nucleotide sequences of open reading frames in the C subtsugae genome (i.e., C. subtsugae genes). In addition, the amino acid sequences of proteins encoded by the C. subtsugae genome are provided. Nucleic acids, vectors and polypeptides comprising the aforementioned sequences are also provided. Homologues, functional fragments and conservative variants of the aforementioned sequences are also provided. Compositions having pesticidal, bioremedial and plant growth-promoting activities comprising C. subtsugae genes and proteins, and methods for the use of these compositions, are also provided.

    Uses of thaxtomin and thaxtomin compositions as herbicides
    19.
    发明授权
    Uses of thaxtomin and thaxtomin compositions as herbicides 有权
    thaxtomin和thaxtomin组合物用作除草剂

    公开(公告)号：US09066516B2

    公开(公告)日：2015-06-30

    申请号：US13841606

    申请日：2013-03-15

    申请人： Marrone Bio Innovations, Inc.

    发明人： Marja Koivunen ,  Pamela Marrone ,  Louis Boddy

    IPC分类号： A01N43/60 ,  A01N43/70

    CPC分类号： A01N43/60 ,  A01N27/00 ,  A01N37/22 ,  A01N37/40 ,  A01N37/44 ,  A01N39/02 ,  A01N39/04 ,  A01N43/36 ,  A01N43/54 ,  A01N43/70 ,  A01N43/76 ,  A01N43/80 ,  A01N43/90 ,  A01N47/12 ,  A01N57/20 ,  A01N59/16 ,  A01N63/02 ,  A01N65/00 ,  A01N65/28 ,  A01N65/44

    摘要： There is a need for a selective, low-risk herbicide that can be used to control weeds in cereal cultures and turf. The present invention discloses that a bacterial secondary metabolite, thaxtomin and optionally another herbicide is an effective herbicide on broadleaved, sedge and grass weeds. Thaxtomin A and structurally similar compounds can be used as natural herbicides to control the germination and growth of weeds in cereal, turf grass, Timothy grass and pasture grass cultures with no phytotoxicity to these crops. As a natural, non-toxic compound, thaxtomin can be used as a safe alternative for weed control in both conventional and organic farming and gardening systems.

    摘要翻译： 需要一种选择性，低风险的除草剂，可用于控制谷物培养和草皮中的杂草。 本发明公开了一种细菌次级代谢物，thaxtomin和任选的另一种除草剂，是对阔叶，薹草和禾本科杂草的有效除草剂。 Thaxtomin A和结构类似的化合物可用作天然除草剂，以控制谷物，草坪草，提摩诃草和牧草草培养物中杂草的发芽和生长，对这些作物无植物毒性。 作为天然的无毒化合物，thaxtomin可以用作常规和有机农业和园艺系统中杂草控制的安全替代品。

    Total synthesis of thaxtomin A analogues and their intermediates
    20.
    发明授权
    Total synthesis of thaxtomin A analogues and their intermediates 有权
    thaxtomin A类似物及其中间体的全合成

    公开(公告)号：US08993762B2

    公开(公告)日：2015-03-31

    申请号：US13840975

    申请日：2013-03-15

    申请人： Marrone Bio Innovations, Inc

    发明人： Huazhang Huang ,  Dong Yan ,  Zhijie Xue ,  Hongbo Zhang

    IPC分类号： C07D403/06

    CPC分类号： C07D403/06

    摘要： Improved synthetic methods for the production of thaxtomin analogs, particularly thaxtomin A, and intermediates therefore such as substituted tryptophans and in particular, 4-nitro-L-tryptophan, and substituted phenyl acrylic acids are disclosed. Bioassays show that the synthetic thaxtomin A is not significantly different from the natural one in herbicidal activity.

    摘要翻译： 公开了用于生产thax​​tomin类似物，特别是thaxtomin A的改进的合成方法，因此例如取代的色氨酸，特别是4-硝基-L-色氨酸和取代的苯基丙烯酸的中间体。 生物测定表明，合成thaxtomin A与天然的除草活性没有显着差异。