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公开(公告)号：US20050214322A1
公开(公告)日：2005-09-29
申请号：US10967395
申请日：2004-10-18
IPC分类号： A61K39/015 , A61K39/116 , A61K39/245 , A61K39/29 , A61K39/295 , A61K39/39
CPC分类号： A61K39/245 , A61K39/015 , A61K39/12 , A61K39/292 , A61K39/39 , A61K2039/55505 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2710/16634 , C12N2730/10134 , C12N2740/13034
摘要： The invention relates to a vaccine composition comprising an antigen, an immunologically active saponin fraction and a sterol.
摘要翻译： 本发明涉及包含抗原，免疫活性皂苷级分和甾醇的疫苗组合物。
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12.发明申请Epitopes or mimotopes derived from the C-epsilon-3 or C-epsilon-4 domains of IgE, antagonists thereof, and their therapeutic uses 审中-公开衍生自IgE的C-ε-3或C-ε-4结构域的表位或模拟表位，其拮抗剂及其治疗用途公开(公告)号：US20050214285A1
公开(公告)日：2005-09-29
申请号：US11005794
申请日：2004-12-07
申请人： Michael Dyson , Martin Friede , Judith Greenwood , Ellen Hewitt , Alan Lamont , Sean Mason , Roger Randall , William Turnell , Marcelle Van Mechelen , Carlotta y de Bassols
发明人： Michael Dyson , Martin Friede , Judith Greenwood , Ellen Hewitt , Alan Lamont , Sean Mason , Roger Randall , William Turnell , Marcelle Van Mechelen , Carlotta y de Bassols
IPC分类号： A61K39/00 , A61K39/395 , C07K16/42 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6875 , A61K39/0008 , A61K2039/505 , A61K2039/6056 , C07K16/4291 , G01N2800/24
摘要： The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are isolated peptides incorporating epitopes or mimotopes of surface exposed regions of the Cε2 domain of IgE. The inventors have found that these novel regions may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the surface exposed IgE regions of the present invention, and their use in medicine as passive immunotherapy or in immunoprophylaxis.
摘要翻译： 本发明涉及提供用于治疗，预防或改善过敏性疾病的新型药物。 特别地，新型药物是包含IgE的Cepsilon2结构域的表面暴露区域的表位或模拟表位的分离肽。 发明人已经发现，这些新的区域可能是被动和主动免疫预防或免疫治疗的目标。 本发明还涉及制备药物的方法，含有它们的药物组合物及其在药物中的用途。 还形成本发明的一个方面是能够结合本发明的表面暴露的IgE区域的配体，特别是单克隆抗体，以及它们在医学中作为被动免疫治疗或免疫预防的用途。
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13.发明授权Vaccine composition comprising herpes simplex virus and human papilloma virus antigens 失效包含单纯疱疹病毒和人乳头状瘤病毒抗原的疫苗组合物公开(公告)号：US06936255B1
公开(公告)日：2005-08-30
申请号：US10070479
申请日：2000-09-07
IPC分类号： A61K39/23 , A61K39/002 , A61K39/12 , A61K39/125 , A61K39/245 , A61K39/25 , A61K39/29 , A61K39/295 , A61K39/39 , A61K47/02 , A61P31/12 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/04 , B09C1/00 , E02D3/00 , E02D3/11
CPC分类号： C07K16/084 , A61K39/12 , A61K39/292 , A61K39/39 , A61K2039/5258 , A61K2039/55505 , A61K2039/55572 , A61K2039/57 , A61K2039/70 , B09C1/00 , C12N2710/20023 , C12N2710/20034 , C12N2730/10134 , E02D3/11 , Y02A50/464
摘要： Novel combined vaccine compositions are provided, comprising a herpes simplex virus (HSV) antigen and a HPV antigen and optionally in addition one or more of the following: an EBV antigen, a hepatitis A antigen or inactivated attenuated virus, a hepatitis B viral antigen, a VZV antigen, a HCMV antigen, a Toxoplasma gondii antigen. The vaccine compositions are formulated with an adjuvant which is a preferential stimulator of TH1 cell response such as 3D-MPL and QS21.
摘要翻译： 提供了新型组合疫苗组合物，其包含单纯疱疹病毒（HSV）抗原和HPV抗原，并且任选另外包含以下一种或多种：EBV抗原，甲型肝炎抗原或灭活的减毒病毒，乙型肝炎病毒抗原， VZV抗原，HCMV抗原，弓形体弓形虫抗原。 疫苗组合物配制有佐剂，其是TH1细胞应答的优选刺激物，例如3D-MPL和QS21。
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公开(公告)号：US20050112144A1
公开(公告)日：2005-05-26
申请号：US10878094
申请日：2004-06-28
申请人： Erik D'Hondt
发明人： Erik D'Hondt
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , C12N2770/32451 , C12N2770/32463 , C12N2770/32471
摘要： A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a)culturing Hepatitis A virus and harvesting a Hepatitis A preparation; b) treating said Hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease-digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated Hepatitis A virus, preferably in combination with strong adjuvants.
摘要翻译： 描述了生产基本上不含宿主细胞污染的灭活的甲型肝炎病毒的方法，该方法包括：a）培养甲型肝炎病毒并收获甲型肝炎制剂; b）用蛋白酶处理所述甲型肝炎制剂; 然后c）将完整病毒与蛋白酶消化的材料分离; d）使所述病毒失活。 还描述了包含灭活的甲型肝炎病毒的疫苗，优选与强佐剂组合。
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公开(公告)号：US06893644B2
公开(公告)日：2005-05-17
申请号：US10465763
申请日：2003-06-19
申请人： Nathalie Marie-Josephe Claude Garcon-Johnson , Pierre Hauser , Clothilde Thiriart , Pierre Voet
发明人： Nathalie Marie-Josephe Claude Garcon-Johnson , Pierre Hauser , Clothilde Thiriart , Pierre Voet
IPC分类号： A61K39/29 , A61K39/295 , A61K45/00 , A61K47/44
CPC分类号： A61K39/292 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/545 , A61K2039/55505 , A61K2039/55572 , A61K2039/57 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , Y02A50/464 , Y02A50/466
摘要： A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid. A combination vaccines including the vaccine formulation are also described.
摘要翻译： 提供用于治疗或预防肝炎，特别是肝炎，特别是乙型肝炎感染的疫苗制剂，其包含肝炎抗原和合适的载体如明矾与3-O-脱酰基单磷酰脂质的组合。 还描述了包括疫苗制剂的组合疫苗。
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16.发明申请Polypeptides and polynucleotides "BASB040" from neisseria meningitidis and vaccine comprising said polypeptides and polynucleotides 审中-公开来自脑膜炎奈瑟氏球菌的多肽和多核苷酸“BASB040”和包含所述多肽和多核苷酸的疫苗公开(公告)号：US20040265878A1
公开(公告)日：2004-12-30
申请号：US10833884
申请日：2004-04-28
发明人： Jean-Louis Ruelle
IPC分类号： C12Q001/68 , G01N033/554 , G01N033/569 , C07H021/04 , C12P021/04 , C07K014/195
CPC分类号： C07K14/22 , A61K39/00 , C07K2319/00 , G01N2333/22
摘要： The invention provides BASB040 polypeptides and polynucleotides from Neisseria meningitidis encoding BASB040 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
摘要翻译： 本发明提供BASB040多肽和编码BASB040多肽的脑膜炎奈瑟球菌的多核苷酸，以及通过重组技术产生此类多肽的方法。 还提供诊断，预防和治疗用途。
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17.发明申请BASB029 polynucleotide(s) and polypeptides from Neisseria meningitidis 审中-公开来自脑膜炎奈瑟球菌的BASB029多核苷酸和多肽公开(公告)号：US20040265332A1
公开(公告)日：2004-12-30
申请号：US10896778
申请日：2004-07-22
发明人： Jean-Louis Ruelle
IPC分类号： A61K039/02 , C12Q001/68 , C07H021/04 , C12N001/21 , C07K014/195 , C12N015/74
CPC分类号： C07K16/1217 , A61K39/00 , A61K2039/505 , A61K2039/51 , A61K2039/53 , C07K14/22 , C12Q1/689 , G01N33/56911
摘要： The invention provides BASB029 polypeptides and polynucleotides encoding BASB029 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
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18.发明申请BASB027 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses 失效BASB027蛋白质和来自卡他莫拉菌的基因，抗原，抗体和用途公开(公告)号：US20040265331A1
公开(公告)日：2004-12-30
申请号：US10896725
申请日：2004-07-22
IPC分类号： C12Q001/68 , C07H021/04 , A61K039/02 , C12N001/21 , C07K014/195
CPC分类号： C07K14/212 , A61K39/00 , C07K2319/00
摘要： The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
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公开(公告)号：US20040241193A1
公开(公告)日：2004-12-02
申请号：US10883126
申请日：2004-07-01
IPC分类号： A61K039/29
CPC分类号： A61K39/29 , A61K39/12 , A61K39/292 , A61K2039/545 , A61K2039/55505 , C12N2730/10134 , C12N2770/32434 , Y02A50/464
摘要： Novel vaccine compositions are provided comprising a hepatitis B antigen formulated with aluminium phosphate. The vaccine compositions may additionally contain an inactivated hepatitis A virus, aluminium hydroxide and formol. The combined hepatitis A and B vaccine formulations can, if desired, be administered to human subjects in a 2 dose regimen. Suitable formulations are illustrated.
摘要翻译： 提供了包含用磷酸铝配制的乙型肝炎抗原的新型疫苗组合物。 疫苗组合物还可以含有灭活的甲型肝炎病毒，氢氧化铝和甲醛。 如果需要，联合的甲型和乙型肝炎疫苗制剂可以以2剂量方案给予人类受试者。 示出了合适的制剂。
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公开(公告)号：US20030180317A1
公开(公告)日：2003-09-25
申请号：US10385136
申请日：2003-03-10
发明人： Jean-Louis Ruelle
IPC分类号： A61K039/02 , C07H021/04 , C12N001/21 , C12P021/02 , C07K014/195 , C12N015/74
CPC分类号： C07K14/212 , A61K39/00 , A61K2039/51
摘要： Provided are Moraxella catarrhalis BASB034 polypeptides and immunogenic fragments of BASB034 polypeptides. Preferably, the immunogenic fragments have at least 15 amino acids that match an aligned contiguous segment of SEQ ID NOs:2, 4, 6 or 8. The immunogenic fragments, when administered to a subject in a suitable composition (which can include an adjuvant, or a suitable carrier coupled to the fragment) raise an immune response that recognizes a polypeptide having the sequence of SEQ ID NOs:2, 4, 6 or 8. The invention further provides immunogenic compositions containing BASB034 polypeptides and immunogenic fragments thereof, and a pharmaceutically acceptable carrier. Also provided are fusion proteins that contain BASB034 polypeptides and immunogenic fragments thereof.
摘要翻译： 提供卡他莫拉菌属BASB034多肽和BASB034多肽的免疫原性片段。 优选地，免疫原性片段具有与SEQ ID NO：2,4,6或8的排列的连续片段匹配的至少15个氨基酸。当以适合的组合物（其可以包括佐剂）施用于受试者时，免疫原性片段， 或与片段偶联的合适的载体）引起识别具有SEQ ID NO：2,4,6或8的序列的多肽的免疫应答。本发明还提供含有BASB034多肽及其免疫原性片段的免疫原性组合物， 可接受的载体 还提供了含有BASB034多肽和其免疫原性片段的融合蛋白。
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