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    Thrombin activator compositions and methods of making and using the same
    15.
    发明授权
    Thrombin activator compositions and methods of making and using the same 有权
    凝血酶活化剂组合物及其制备和使用方法

    公开(公告)号：US08759066B2

    公开(公告)日：2014-06-24

    申请号：US12935235

    申请日：2009-04-07

    申请人： Paul D. Bishop ,  Tracey A. Pownder ,  Paul O. Sheppard ,  Christopher J. Stenland

    发明人： Paul D. Bishop ,  Tracey A. Pownder ,  Paul O. Sheppard ,  Christopher J. Stenland

    IPC分类号： C12N9/48 ,  C12N15/00 ,  C12P21/06 ,  C12P21/04 ,  C07H21/04

    CPC分类号： C12N9/6418 ,  C07K2319/50

    摘要： Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering said compositions, activating said compositions purifying said compositions and producing active thrombin molecules using the active form of said compositions.

    摘要翻译： 公开了用于激活凝血酶凝血酶前体的组合物。 提供的组合物包括多肽组合物，其中前序列包含凝血酶切割位点。 提供的组合物还包括编码所述多肽的多核苷酸和用于表达所述多肽的重组系统。 本公开还涉及生产所述组合物的方法，回收所述组合物，使用所述组合物的活性形式活化所述组合物来纯化所述组合物并产生活性凝血酶分子。

    Polynucleotides encoding antibodies to cytokine receptor zcytor17
    17.
    发明授权
    Polynucleotides encoding antibodies to cytokine receptor zcytor17 有权
    编码细胞因子受体zcytor17抗体的多核苷酸

    公开(公告)号：US08648182B2

    公开(公告)日：2014-02-11

    申请号：US13649217

    申请日：2012-10-11

    申请人： ZymoGenetics, Inc.

    发明人： Cindy A. Sprecher ,  Scott R. Presnell ,  Zeren Gao ,  Theodore E. Whitmore ,  Joseph L. Kuijper ,  Mark F. Maurer

    IPC分类号： C12N15/12 ,  C07H21/04 ,  C07K16/28 ,  C12N15/64 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47

    CPC分类号： C07K14/715

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

    METHODS FOR USING TACI-IMMUNOGLOBULIN FUSION PROTEINS
    20.
    发明申请
    METHODS FOR USING TACI-IMMUNOGLOBULIN FUSION PROTEINS 有权
    使用TACI-IMMUNOGLOBULIN融合蛋白的方法

    公开(公告)号：US20130309231A1

    公开(公告)日：2013-11-21

    申请号：US13956499

    申请日：2013-08-01

    申请人： Zymogenetics, Inc.

    发明人： Mark W. Rixon ,  Jane A. Gross

    IPC分类号： C07K16/24

    CPC分类号： C07K16/241 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/30

    摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.

    摘要翻译： 干扰肿瘤坏死因子受体与其配体如可溶性受体的结合的分子已被证明在基础研究和治疗中都是有用的。 本发明提供改进的可溶性跨膜激活剂和钙调节剂和亲环蛋白配体相互作用（TACI）受体。