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    Homolactic fermentation from pentose
    12.
    发明授权
    Homolactic fermentation from pentose 有权
    来自戊糖的均相发酵

    公开(公告)号：US08715972B2

    公开(公告)日：2014-05-06

    申请号：US13202218

    申请日：2010-02-15

    申请人： Akihiko Kondo ,  Kenji Okano ,  Hideo Noda

    发明人： Akihiko Kondo ,  Kenji Okano ,  Hideo Noda

    IPC分类号： C12P7/56 ,  C12N1/20 ,  C12N15/00 ,  C12N15/87 ,  C12N15/74

    CPC分类号： C12P7/56 ,  C12N9/88

    摘要： Provided is a lactic acid bacterium capable of homolactic fermentation using a pentose as a substrate, the lactic acid bacterium utilizing a pentose, and in which a phosphoketolase pathway is blocked and a pentose phosphate pathway is activated. Also provided is a method for producing lactic acid from a pentose using the lactic acid bacterium and a method for preparing the lactic acid bacterium.

    摘要翻译： 本发明提供能够使用戊糖作为基质进行均相发酵的乳酸菌，利用戊糖的乳酸菌，磷酸酮糖苷酶途径被阻断，磷酸戊糖途径被活化。 还提供了使用乳酸菌从戊糖生产乳酸的方法和制备乳酸菌的方法。

    Radiation therapy agent
    13.
    发明授权
    Radiation therapy agent 有权
    放射治疗剂

    公开(公告)号：US08580312B2

    公开(公告)日：2013-11-12

    申请号：US13578836

    申请日：2011-02-17

    申请人： Chiaki Ogino ,  Tsutomu Tanaka ,  Ryohei Sasaki ,  Akihiko Kondo

    发明人： Chiaki Ogino ,  Tsutomu Tanaka ,  Ryohei Sasaki ,  Akihiko Kondo

    IPC分类号： A61P35/00 ,  A61K9/14 ,  A61K39/395 ,  C07K16/18 ,  C07K16/00

    CPC分类号： A61K9/0019 ,  A61K33/40 ,  A61K41/0057 ,  A61K47/6835 ,  A61K2039/505 ,  A61N5/10 ,  A61N2005/1098 ,  C07K16/2863 ,  Y10T428/2982

    摘要： Provided is a radiotherapeutic agent, including a composite particle, which is obtained by binding a molecule that specifically recognizes a target to a substrate particle including titanium peroxide, and which generates reactive oxygen through irradiation with a radiation. Further, because the radiotherapeutic agent contains the molecule that specifically recognizes a target, the radiotherapeutic agent has a function of accumulating in the target. The radiotherapeutic agent is capable of enhancing effects of radiotherapy, and is capable of reducing side effects on a living body to efficiently attack the target.

    摘要翻译： 本发明提供一种放射治疗剂，包括复合颗粒，其通过将特异性识别靶标的分子与包含过氧化钛的底物颗粒结合而获得，并且通过辐射照射产生活性氧。 此外，由于放射治疗剂含有特异性识别靶标的分子，所以放射治疗剂具有累积在靶内的功能。 放射治疗剂能够增强放射疗法的作用，并且能够减少对活体的副作用以有效地攻击靶。

    PRODUCTION AND USE OF YEAST HAVING INCREASED CELLULOSE HYDROLYSIS ABILITY
    14.
    发明申请
    PRODUCTION AND USE OF YEAST HAVING INCREASED CELLULOSE HYDROLYSIS ABILITY 有权
    生产和使用具有增加纤维素水解能力的YEAST

    公开(公告)号：US20110183396A1

    公开(公告)日：2011-07-28

    申请号：US13063225

    申请日：2009-09-16

    申请人： Hideo Noda ,  Shohei Kaneko ,  Akihiko Kondo

    发明人： Hideo Noda ,  Shohei Kaneko ,  Akihiko Kondo

    IPC分类号： C12P7/10 ,  C12N15/81 ,  C12N1/19

    CPC分类号： C12P7/10 ,  C12N9/2437 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16

    摘要： The present invention provides a method for producing an yeast having an increased cellulose hydrolysis ability. The method includes the step of introducing increased integration copy numbers of both a gene for an enzyme capable of hydrolyzing crystalline cellulose and a gene for an enzyme capable of hydrolyzing noncrystalline cellulose into a noncellulolytic yeast to give a transformed yeast. The yeast having an increased cellulose hydrolysis ability can be suitably used for ethanol production from cellulose-based materials.

    摘要翻译： 本发明提供了具有增加的纤维素水解能力的酵母的制造方法。 该方法包括将能够水解结晶纤维素的酶的基因和能够将非结晶纤维素水解的酶的基因的基因的增加的整合拷贝数引入非溶解酵母以产生转化的酵母的步骤。 具有增加的纤维素水解能力的酵母可以适用于从纤维素基材料制备乙醇。

    METHOD AND INTRODUCTION OF GENE INTO YEAST CELL, AND VECTOR FOR THE METHOD
    15.
    发明申请
    METHOD AND INTRODUCTION OF GENE INTO YEAST CELL, AND VECTOR FOR THE METHOD 审中-公开
    基因的方法和引言到YEAST细胞，以及方法的向量

    公开(公告)号：US20110081698A1

    公开(公告)日：2011-04-07

    申请号：US12992118

    申请日：2009-05-11

    申请人： Hideo Noda ,  Shohci Kaneko ,  Akihiko Kondo

    发明人： Hideo Noda ,  Shohci Kaneko ,  Akihiko Kondo

    IPC分类号： C12P7/10 ,  C12N15/81 ,  C12N1/19

    CPC分类号： C12N15/905 ,  C12N9/2445 ,  C12N15/81 ,  C12P7/10 ,  C12Y302/01021 ,  Y02E50/16 ,  Y02E50/17

    摘要： An object of the present invention is a method for introducing a foreign gene into a yeast cell that does not have an auxotrophic marker. The present invention provides a method for providing a target auxotrophy to a yeast cell and introducing a gene to be expressed into the yeast cell. The method includes the step of transforming a yeast cell with a fragment containing an expression cassette for the gene to be expressed, a cassette for a yeast selectable marker, and two homologous recombination fragments each homologous to a region on either side of a target auxotrophy controlling gene. According to the method, a target auxotrophy controlling gene is deleted from a yeast cell and a gene to be expressed is introduced into the yeast cell, and further the yeast selectable marker is eliminated from the transformed yeast cell.

    摘要翻译： 本发明的目的是将外源基因导入到不具有营养缺陷型标记物的酵母细胞中的方法。 本发明提供了向酵母细胞提供目标营养缺陷并将要表达的基因导入酵母细胞的方法。 该方法包括用含有待表达基因的表达盒的片段，用于酵母选择性标记的盒，和与目标营养缺陷型控制的任一侧的区域同源的两个同源重组片段的酵母细胞转化的步骤 基因。 根据该方法，从酵母细胞中缺失目标营养缺陷型控制基因，将待表达的基因导入酵母细胞，进一步从转化的酵母细胞中除去酵母选择标记。

    Remedies with the use of hollow protein nanoparticles presenting growth factor or the like
    18.
    发明申请
    Remedies with the use of hollow protein nanoparticles presenting growth factor or the like 审中-公开
    使用具有生长因子等的中空蛋白质纳米粒子的补救措施

    公开(公告)号：US20060165726A1

    公开(公告)日：2006-07-27

    申请号：US10509248

    申请日：2003-03-05

    申请人： Shunichi Kuroda ,  Katsuyuki Tanizawa ,  Akihiko Kondo ,  Masakazu Ueda ,  Masaharu Seno ,  Hidehiko Iwabuki

    发明人： Shunichi Kuroda ,  Katsuyuki Tanizawa ,  Akihiko Kondo ,  Masakazu Ueda ,  Masaharu Seno ,  Hidehiko Iwabuki

    IPC分类号： A61K39/29 ,  A61K39/245 ,  A61K9/14

    CPC分类号： B82Y5/00 ,  A61K9/5068 ,  A61K48/00

    摘要： The invention provides a disease-treating drug, specifically acting particular cells or tissues, which is based on protein hollow nanoparticles. The drug's therapeutic effects are confirmed through animal experiments. The invention also provides a treatment method using the drug. The disease-treating drug comprises a substance to be transferred into a cell for treatment of a disease (for example, cancer-treating, thymidine kinase gene of herpes simplex virus type 1) encapsulated in hollow nanoparticles containing particle-forming protein (for example, hepatitis B virus surface antigen protein modified to lose infectivity to inherent hepatocyte and also display a growth factor) displaying, for example, a growth factor.

    摘要翻译： 本发明提供一种疾病治疗药物，特别是作用于基于蛋白质中空纳米颗粒的特定细胞或组织。 药物的治疗效果通过动物实验证实。 本发明还提供了使用该药物的治疗方法。 疾病治疗药物包含被包含在含有颗粒形成蛋白质的中空纳米颗粒中的用于治疗疾病（例如，1型单纯疱疹病毒的胸腺嘧啶激酶基因的癌症治疗，胸苷激酶基因）的细胞中的物质（例如， 乙型肝炎病毒表面抗原蛋白被修饰以丧失对固有肝细胞的感染性并且还显示生长因子），显示例如生长因子。

    Drug for treating liver diseases with the use of hollow protein nanoparticles
    19.
    发明申请
    Drug for treating liver diseases with the use of hollow protein nanoparticles 审中-公开
    使用中空蛋白纳米颗粒治疗肝脏疾病的药物

    公开(公告)号：US20060034869A1

    公开(公告)日：2006-02-16

    申请号：US10509252

    申请日：2003-03-05

    申请人： Shunichi Kuroda ,  Katsuyuki Tanizawa ,  Akihiko Kondo ,  Masakazu Ueda ,  Masaharu Seno ,  Hidehiko Iwabuki

    发明人： Shunichi Kuroda ,  Katsuyuki Tanizawa ,  Akihiko Kondo ,  Masakazu Ueda ,  Masaharu Seno ,  Hidehiko Iwabuki

    IPC分类号： A61K39/29 ,  A61K9/14 ,  C12Q1/68

    CPC分类号： B82Y5/00 ,  A61K9/5068 ,  A61K48/00

    摘要： The invention provides a drug for treating hepatic diseases with the use of hollow protein nanoparticles. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method using such a drug. In a drug according to the present invention, a substance to be transferred into a cell for treating a hepatic disease (for example, a cancer treating gene such as a thymidine kinase gene derived from simple herpes virus) is encapsulated in hollow nanoparticles that have an ability to recognize a hepatocyte and are composed of a particle-forming protein (for example, hepatitis B virus surface-antigen protein).

    摘要翻译： 本发明提供了一种使用中空蛋白纳米颗粒治疗肝病的药物。 药物的有效性已经通过动物实验证明。 本发明还提供了使用这种药物的治疗方法。 在根据本发明的药物中，将被转移到用于治疗肝脏疾病的细胞中的物质（例如，衍生自简单疱疹病毒的胸腺嘧啶激酶基因等癌症治疗基因）被包封在具有 能够识别肝细胞并由形成颗粒的蛋白质（例如乙型肝炎病毒表面抗原蛋白质）组成。

    Method for measuring protozoan oocyst and detecting reagent
    20.
    发明授权
    Method for measuring protozoan oocyst and detecting reagent 有权
    测量原生动物卵囊和检测试剂的方法

    公开(公告)号：US09297799B2

    公开(公告)日：2016-03-29

    申请号：US11813563

    申请日：2006-01-11

    申请人： Noriyuki Ohnishi ,  Hirotaka Furukawa ,  Hideyuki Hata ,  Kageaki Matsui ,  Takako Nogami ,  Hideo Nishizawa ,  Akihiko Kondo

    发明人： Noriyuki Ohnishi ,  Hirotaka Furukawa ,  Hideyuki Hata ,  Kageaki Matsui ,  Takako Nogami ,  Hideo Nishizawa ,  Akihiko Kondo

    IPC分类号： G01N33/553 ,  G01N33/543 ,  G01N33/569

    CPC分类号： G01N33/54326 ,  G01N33/56905

    摘要： The present invention provides a method for measuring oocyst of protozoa, such as Cryptosporidium, in an environment sample with high sensitivity at low cost within a short period of time; and a detecting reagent for use therein.Magnetic fine particles of 5 to 500 nm particle diameter having, immobilized thereto, binding factors for specific recognition of oocyst are added to an analyte containing a protozoan oocyst to form oocyst/binding factor/magnetic fine particle complexes by using a binding reaction to the oocyst, the formed complexes are recovered by a magnetic separation, and the protozoan oocysts contained in the complexes are assayed. Further, there is provided, for conducting the above method, a reagent for detecting protozoan oocysts comprising magnetic fine particles of 5 to 500 nm particle diameter having, immobilized thereto, antibodies against oocysts or binding factors for recognizing the antibodies.

    摘要翻译： 本发明提供了一种在短时间内以低成本在环境样品中测定原生动物如隐孢子虫的卵囊的方法，所述环境样品具有高灵敏度; 和其中使用的检测试剂。 将固定有5〜500nm粒径的磁性细颗粒加入到含有原生动物卵囊的分析物中以形成卵囊/结合因子/磁性细颗粒复合物，通过使用与卵囊的结合反应 通过磁分离回收形成的复合物，并测定复合物中所含的原生动物卵囊。 此外，为了进行上述方法，提供了一种用于检测原生动物卵囊的试剂，其包括具有5至500nm粒径的磁性细颗粒，其固定有针对卵囊的抗体或用于识别抗体的结合因子。