公开(公告)号：US20110112121A1

公开(公告)日：2011-05-12

申请号：US12827218

申请日：2010-06-30

Applicant: Joerg BERGHAUSEN ,  Claire HAUG ,  Michael HERBIG ,  Bin HU ,  Stéphane JONAT ,  Rajender LELETI ,  Josef Gottfried MEINGASSNER ,  Stéphanie MONNIER ,  Matthias NAPP ,  Mahavir PRASHAD ,  Anton STÜTZ ,  Ranjit THAKUR

Inventor： Joerg BERGHAUSEN ,  Claire HAUG ,  Michael HERBIG ,  Bin HU ,  Stéphane JONAT ,  Rajender LELETI ,  Josef Gottfried MEINGASSNER ,  Stéphanie MONNIER ,  Matthias NAPP ,  Mahavir PRASHAD ,  Anton STÜTZ ,  Ranjit THAKUR

IPC: A61K31/505 ,  A61P17/00 ,  A61P17/06 ,  C07D239/02

CPC classification number: A61K31/505 ,  A61K9/0014 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  C07D239/34

Abstract: The present invention relates to pharmaceutical compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide, to the use of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide and compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide in therapeutic applications, especially indications with a dysregulation/overexpression of VEFG, (neo)-vascularisation and VEGF driven angiogenesis and to methods for manufacturing such compositions, the invention further relates to specific forms of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide and to the manufacturing and use of such forms. The present invention also relates to a new process to produce 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide.

Abstract translation: 本发明涉及6-（6-羟基甲基 - 嘧啶-4-基氧基） - 萘-1-羧酸（3-三氟甲基 - 苯基） - 酰胺的药物组合物，其用于6-（6-羟甲基 - 嘧啶 -4-基氧基） - 萘-1-羧酸（3-三氟甲基 - 苯基） - 酰胺和6-（6-羟基甲基 - 嘧啶-4-基氧基） - 萘-1-甲酸（3-三氟甲基 - 苯基） ） - 酰胺在治疗应用中，特别是VEFG（neo）血管形成和VEGF驱动的血管发生的失调/过度表达的适应症以及制备这种组合物的方法，本发明还涉及6-（6-羟甲基嘧啶 -4-基氧基） - 萘-1-羧酸（3-三氟甲基 - 苯基） - 酰胺，并且制备和使用这种形式。 本发明还涉及产生6-（6-羟甲基 - 嘧啶-4-基氧基） - 萘-1-羧酸（3-三氟甲基 - 苯基） - 酰胺的新方法。

公开(公告)号：US20110022253A1

公开(公告)日：2011-01-27

申请号：US12810704

申请日：2008-12-26

Applicant: Zhiqiang Chen ,  Shangmin Sun ,  Xining Xu ,  Weizhi Lin ,  Yanwei Xu ,  Shenbin Guo ,  Bin Hu ,  Guang Yang

Inventor： Zhiqiang Chen ,  Shangmin Sun ,  Xining Xu ,  Weizhi Lin ,  Yanwei Xu ,  Shenbin Guo ,  Bin Hu ,  Guang Yang

IPC: G06F19/00

CPC classification number: B61L25/041 ,  B61L1/14 ,  B61L1/161 ,  B61L1/165 ,  B61L25/028 ,  B61L25/045

Abstract: The present invention relates to a method and system for automatically identifying various information of a train. The method comprises using sensors to collect wheelbase information, processing the information by signal data processing devices, thereby providing information of a train, namely: arranging a plurality of sensors along the rail in the incoming direction of the train, dividing the sensors into at least three groups, each group comprising at least two sensors; analyzing and processing the signal data stream obtained from the sensors and collected when a train vehicle passes by, thereby acquiring the speed and wheelbase of the train, and further acquiring the train segmentation information; determining the vehicle type; acquiring hook locating information; determining the train arrival; determining the train departure; acquiring vehicle number. The present invention further comprises a system for carrying out the information method for automatically identifying information of a train. The present invention can provide a plurality of types of train information with high accuracy, and is easy to be carried out.

Abstract translation: 本发明涉及一种用于自动识别列车的各种信息的方法和系统。 该方法包括使用传感器来收集轴距信息，通过信号数据处理装置处理信息，从而提供列车的信息，即沿列车的输入方向沿轨道布置多个传感器，至少将传感器分成 三组，每组包括至少两个传感器; 分析和处理从传感器获得的信号数据流，并在火车车辆通过时收集，从而获取列车的速度和轴距，并进一步获取列车分段信息; 确定车辆类型; 获取挂钩定位信息; 确定列车到达; 确定列车离开; 获取车辆编号。 本发明还包括一种用于执行用于自动识别列车信息的信息方法的系统。 本发明能够提供高精度的多种列车信息，容易进行。

公开(公告)号：US07845286B2

公开(公告)日：2010-12-07

申请号：US11966053

申请日：2007-12-28

Applicant: Bin Hu ,  Wanquan Shen ,  Zhizhong Liang ,  Hua Peng ,  Shangmin Sun ,  Nan Jiang ,  Quanwei Song ,  Weirong Huang ,  Zhenbin Guo ,  Sheng Tang ,  Guang Yang

Inventor： Bin Hu ,  Wanquan Shen ,  Zhizhong Liang ,  Hua Peng ,  Shangmin Sun ,  Nan Jiang ,  Quanwei Song ,  Weirong Huang ,  Zhenbin Guo ,  Sheng Tang ,  Guang Yang

IPC: B66F7/00

CPC classification number: G01V5/0008

Abstract: The present invention relates to a trailer system, and particularly to a self-driving trailer system for a radiation imaging inspection system and a method for inspecting a vehicle by radiation imaging of a vehicle through the trailer system. The self-driving trailer system comprises two trailers symmetrical in structure. Each of the trailers comprises a driving device, running wheels, a trailer body, a carrying device, a lift cylinder, a balance wheel, and two pairs of guide wheels. The driving device, the running wheels, and the balance wheel are coupled with the trailer body. The carrying device is coupled with the trailer body through the lift cylinder. A front carrying arm and a rear carrying arm can clamp front wheels of a vehicle under inspection, and move upwards and downwards by the lift cylinder. The trailer system according to the present invention is smooth and reliable in operation and simple in structure, and is applicable to different diameters of wheels of container lorries under inspection and is convenient in operation.

Abstract translation: 拖车系统技术领域本发明涉及一种拖车系统，特别涉及一种用于辐射成像检查系统的自行车拖车系统和通过拖车系统对车辆进行辐射成像检查车辆的方法。 自行车拖车系统包括两个结构对称的拖车。 每个拖车包括驱动装置，行驶轮，拖车车身，运送装置，提升缸，摆轮和两对导向轮。 驱动装置，行驶轮和摆轮与拖车主体联接。 承载装置通过提升缸与拖车主体联接。 前承载臂和后承载臂可以夹紧检查车辆的前轮，并通过提升缸上下移动。 根据本发明的拖车系统操作平稳可靠，结构简单，适用于检查中集装箱货车的不同直径，操作方便。

公开(公告)号：US20100042601A1

公开(公告)日：2010-02-18

申请号：US12191055

申请日：2008-08-13

Applicant: Sean Kelley ,  Bin Hu

Inventor： Sean Kelley ,  Bin Hu

IPC: G06F7/06 ,  G06F17/30

CPC classification number: H04L67/24 ,  H04L67/18 ,  H04L67/306 ,  H04W4/02

Abstract: A method and system are disclosed allowing for determining those users of multiple users who satisfy desired condition(s), where characteristics of the users in at least some embodiments vary dynamically. In at least one embodiment, the method includes receiving at a server device a request for a determination regarding which of a plurality of users satisfies a plurality of conditions respectively relating to a plurality of user characteristics, and obtaining at the server device a conditions specification. Additionally, the method includes accessing at least one repository in which is stored information regarding the users to obtain at least some of the information, the information concerning the user characteristics. The method also includes making a determination regarding which of the users satisfies the plurality of conditions, obtaining at the first server device updated information from the at least one repository, reevaluating the determination, and sending output information regarding the re-evaluated determination.

Abstract translation: 公开了一种方法和系统，其允许确定满足期望条件的多个用户的那些用户，其中至少一些实施例中的用户的特征动态变化。 在至少一个实施例中，该方法包括在服务器设备处接收关于多个用户中的哪一个满足多个用户特征的多个条件的确定请求，以及在服务器设备处获取条件规范。 此外，该方法包括访问至少一个存储库，其中存储关于用户的信息以获得关于用户特征的信息中的至少一些信息。 该方法还包括确定哪个用户满足多个条件，从第一服务器设备获取来自至少一个存储库的更新信息，重新评估该确定，以及发送关于重新评估的确定的输出信息。

公开(公告)号：US20090271068A1

公开(公告)日：2009-10-29

申请号：US12428191

申请日：2009-04-22

Applicant: Junping Shi ,  Shangmin Sun ,  Jinning Liang ,  Quanwei Song ,  Yucheng Wu ,  Bin Hu ,  Yanjun Han ,  Xuejing Yang

Inventor： Junping Shi ,  Shangmin Sun ,  Jinning Liang ,  Quanwei Song ,  Yucheng Wu ,  Bin Hu ,  Yanjun Han ,  Xuejing Yang

IPC: G06F7/00

CPC classification number: G01V5/0008

Abstract: A detection apparatus comprises a freely-movable integral framework provided with front wheels and rear wheels, characterized in that, a control portion and a scan portion, and a driving mechanism driving said framework to move are provided on said framework, wherein said framework is provided with a first interface for connecting to external power, so that said detection apparatus is driven by external power via the driving mechanism to perform detection while conducting detection on site, and wherein the semitrailer for mounting the framework is provided with a second interface connectable to a traction apparatus so as to connect the detection apparatus and the traction apparatus while carrying out site-changing transportation. Said detection apparatus is not affected by the alteration of the emission standards, has low failure rate and maintenance cost, has zero emission in the detection state, and is pollution-free.

Abstract translation: 检测装置包括设置有前轮和后轮的可自由移动的整体框架，其特征在于，在所述框架上设置有控制部分和扫描部分以及驱动所述框架移动的驱动机构，其中提供所述框架 具有用于连接到外部电力的第一接口，使得所述检测装置经由驱动机构由外部电力驱动，以在现场进行检测时执行检测，并且其中用于安装框架的半挂车设置有可连接到 牵引装置，以便在进行现场改变运输时连接检测装置和牵引装置。 所述检测装置不受排放标准变更的影响，故障率低，维护成本低，检测状态为零排放，无污染。

公开(公告)号：US20090247581A1

公开(公告)日：2009-10-01

申请号：US12085056

申请日：2006-11-16

Applicant: Mahavir Prashad ,  Yugang Liu ,  Bin Hu ,  Michael J. Girgis ,  Frank Schaefer

Inventor： Mahavir Prashad ,  Yugang Liu ,  Bin Hu ,  Michael J. Girgis ,  Frank Schaefer

IPC: C07D211/26 ,  A61K31/445

CPC classification number: C07D211/26 ,  C07B57/00

Abstract: The present invention relates to a process for the synthesis of (S)-2′[2-1-(methyl-2-piperidyl) ethyl] cinnamanilide (I) or salts or pharmaceutically acceptable prodrugs thereof:

Abstract translation: 本发明涉及合成（S）-2'[2-1-（甲基-2-哌啶基）乙基]肉桂酰苯胺（I）或其盐或其药学上可接受的前药的方法：

公开(公告)号：US20090131707A1

公开(公告)日：2009-05-21

申请号：US12272552

申请日：2008-11-17

Applicant: Mahavir Prashad ,  Hong-Yong Kim ,  Bin Hu ,  Joel Slade ,  Prasad Koteswara Kapa ,  Michael John Girgis

Inventor： Mahavir Prashad ,  Hong-Yong Kim ,  Bin Hu ,  Joel Slade ,  Prasad Koteswara Kapa ,  Michael John Girgis

IPC: C07C227/16

CPC classification number: C07D401/12 ,  C07B2200/07 ,  C07C51/487 ,  C07C239/20 ,  C07C59/01

Abstract: Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular I3-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxypropionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.

Abstract translation: 用于制备可用于制备抗菌N- [1-氧代-2-烷基-3-（N-羟基甲酰氨基） - 丙基} - （羰基氨基 - 芳基或 - 杂芳基） - 偶氮环-4-烯烷或噻唑烷-4-7烷烃的中间体的改进方法，其具有一个或 更多的以下特点：（1）利用特定的内酰胺中间体; （2），其使用特定的拆分剂，对映体纯的取代的丙酸，特别是（R）-2-丁基-3-羟基丙酸; （3）避免使用过氧化氢; 和（4）促进选择性脱苄基化减少废弃副产物的生产。

公开(公告)号：US07452999B2

公开(公告)日：2008-11-18

申请号：US10544919

申请日：2004-02-20

Applicant: Mahavir Prashad ,  Hong-Yong Kim ,  Bin Hu ,  Joel Slade ,  Prasad Koteswara Kapa ,  Michael John Girgis

Inventor： Mahavir Prashad ,  Hong-Yong Kim ,  Bin Hu ,  Joel Slade ,  Prasad Koteswara Kapa ,  Michael John Girgis

IPC: C07D417/00 ,  C07D401/00 ,  C07D277/00 ,  C07D207/00 ,  C07D405/00 ,  C07D317/44

CPC classification number: C07D401/12 ,  C07B2200/07 ,  C07C51/487 ,  C07C239/20 ,  C07C59/01

Abstract: Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular β-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxy-propionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.

Abstract translation: 用于制备可用于制备抗菌N- [1-氧代-2-烷基-3-（N-羟基甲酰氨基） - 丙基} - （羰基氨基 - 芳基或 - 杂芳基） - 偶氮基-4-7烷烃或噻唑烷-4-7烷烃的改进方法，其具有 一个或多个以下特征：（1）利用特定的β-内酰胺中间体; （2），其使用特定的拆分剂，对映体纯的取代的丙酸，特别是（R）-2-丁基-3-羟基 - 丙酸; （3）避免使用过氧化氢; 和（4）促进选择性脱苄基化减少废弃副产物的生产。

公开(公告)号：US07452700B2

公开(公告)日：2008-11-18

申请号：US11404741

申请日：2006-04-14

Applicant: Andre R. Abad ,  Ronald D. Flannagan ,  Bin Hu ,  Billy F. McCutchen ,  Xiaofeng Sean Yang ,  Cao Guo Yu

Inventor： Andre R. Abad ,  Ronald D. Flannagan ,  Bin Hu ,  Billy F. McCutchen ,  Xiaofeng Sean Yang ,  Cao Guo Yu

IPC: C12P19/34 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6809 ,  C12Q1/689 ,  C12Q2541/101

Abstract: Methods and compositions for identifying novel pesticidal gene homologues are provided. Specifically, the methods of the invention comprise systematically designing oligonucleotide primers that are specific for a pesticidal gene of interest and performing successive rounds of PCR amplification of nucleic acid material from a microorganism, particularly a Bacillus thuringiensis strain, to identify novel homologues of known pesticidal genes. Oligonucleotide primers that can be used to practice the present methods are further disclosed.

Abstract translation: 提供了鉴定新型杀虫基因同系物的方法和组合物。 具体地说，本发明的方法包括系统地设计针对目的杀虫基因特异性的寡核苷酸引物，并对来自微生物特别是苏云金芽孢杆菌属菌株的核酸材料进行连续循环的PCR扩增，以鉴定已知杀虫基因的新型同系物 。 进一步公开了可用于实施本发明方法的寡核苷酸引物。

公开(公告)号：US20080191606A1

公开(公告)日：2008-08-14

申请号：US11965651

申请日：2007-12-27

Applicant: David Bruce Geohegan ,  Ilya N. Ivanov ,  Alexander A. Puretzky ,  Stephen Jesse ,  Bin Hu

Inventor： David Bruce Geohegan ,  Ilya N. Ivanov ,  Alexander A. Puretzky ,  Stephen Jesse ,  Bin Hu

IPC: H01J1/63 ,  C23C16/26

CPC classification number: H01L51/0048 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/16 ,  C01B32/17 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/08 ,  C01B2202/34 ,  C01B2202/36 ,  C08J5/005 ,  H01B1/24 ,  Y10S428/917

Abstract: The present invention, in one embodiment, provides a method of forming an organic electric device that includes providing a plurality of carbon nanostructures; and dispersing the plurality of carbon nanostructures in a polymeric matrix to provide a polymeric composite, wherein when the plurality of carbon nanostructures are present at a first concentration an interface of the plurality of carbon nanostructures and the polymeric matrix is characterized by charge transport when an external energy is applied, and when the plurality of carbon nanostructures are present at a second concentration the interface of the plurality of carbon nanostructures and the polymeric matrix are characterized by exciton dissociation when an external energy is applied, wherein the first concentration is less than the second concentration.

Abstract translation: 本发明在一个实施方案中提供了一种形成有机电子器件的方法，该方法包括提供多个碳纳米结构; 以及将所述多个碳纳米结构分散在聚合物基质中以提供聚合物复合物，其中当所述多个碳纳米结构以第一浓度存在时，所述多个碳纳米结构和所述聚合物基体的界面的特征在于当外部 施加能量，并且当多个碳纳米结构以第二浓度存在时，当施加外部能量时，多个碳纳米结构和聚合物基体的界面的特征在于激子解离，其中第一浓度小于第二浓度 浓度。