公开(公告)号：US06425578B1

公开(公告)日：2002-07-30

申请号：US09395866

申请日：1999-09-14

Applicant: James Buckingham Wood ,  Colin Marshall ,  Stephen Edward Fox

Inventor： James Buckingham Wood ,  Colin Marshall ,  Stephen Edward Fox

IPC: B65H306

CPC classification number: B65H3/0684 ,  B65H3/5223 ,  B65H3/565 ,  B65H2301/31122 ,  B65H2301/42324 ,  B65H2301/448 ,  B65H2403/20 ,  B65H2403/512 ,  B65H2403/72 ,  B65H2511/40 ,  B65H2513/42 ,  B65H2553/24 ,  B65H2701/18264 ,  B65H2701/1928 ,  B65H2220/01 ,  B65H2220/02

Abstract: Image recording apparatus for recording an image on a recording plate, the apparatus comprising a plate store (1) for storing a stack (12) of recording plates separated by interleaved sheets; a drum image scanner (6) on which recording plates are located for recordal of an image; and a frictional feed apparatus (2) for withdrawing recording plates from the store (1) and feeding them singly to the drum image scanner (6).

Abstract translation: 一种用于在记录板上记录图像的图像记录装置，该装置包括：用于存储由交错片分隔开的记录板的堆叠（12）的板存储器（1）;记录板位于其上以记录的滚筒图像扫描器 的图像 以及用于从存储器（1）取出记录板并将它们单独供给到滚筒图像扫描器（6）的摩擦进给装置（2）。

公开(公告)号：US09283230B2

公开(公告)日：2016-03-15

申请号：US13984841

申请日：2011-08-15

Applicant: Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

Inventor： Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

IPC: A61K31/5415 ,  C07D279/20 ,  C07D309/04 ,  C07C309/05 ,  A61K9/20 ,  C07C309/04 ,  A61K9/28 ,  C07C309/30 ,  C07C309/35

CPC classification number: A61K31/5415 ,  A61K9/0053 ,  A61K9/2095 ,  A61K9/2893 ,  A61L2/0052 ,  C07C303/32 ,  C07C309/04 ,  C07C309/05 ,  C07C309/30 ,  C07C309/35 ,  C07D279/20 ,  Y02A50/393 ,  Y02A50/411

Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

Abstract translation: 本发明涉及通式（I）的化合物：其中：R 1和R 9各自独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R 3NA和R 3NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; 并且其中：RA和RB各自独立地选自：C 1-4烷基，卤代C 1-4烷基和C 6-10芳基; 或RA和RB连接形成选自以下的基团：C 1-6亚烷基和C 6-10亚芳基; 和其药学上可接受的盐，其可用于治疗例如阿尔茨海默氏病。 在其它方面，本发明还涉及3,7-二氨基-10H-吩噻嗪鎓盐的新配方。

公开(公告)号：US08710051B2

公开(公告)日：2014-04-29

申请号：US13011797

申请日：2011-01-21

Applicant: Claude Michel Wischik ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

Inventor： Claude Michel Wischik ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

IPC: A61K31/54 ,  C07D279/18

CPC classification number: C07D279/20 ,  A61K31/5415 ,  A61K49/0002 ,  A61K49/003 ,  A61K51/0465 ,  G01N33/6896 ,  G01N2800/2835 ,  Y02A50/393 ,  Y02A50/411

Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of the following formula: wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methylthioninium chloride, MTC).

Abstract translation: 本发明一般涉及吩噻嗪化合物领域，更具体地涉及某些稳定还原的吩噻嗪化合物，具体地，下列通式的某些3,7-二氨基-10H-吩噻嗪（DAPTZ）化合物：其中：R 1和R 9各自为 独立选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R3NA和R3NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; HX1和HX2各自独立地是质子酸; 及其药学上可接受的盐，溶剂化物和水合物。 这些化合物可用作药物，例如用于治疗tau蛋白病，例如阿尔茨海默氏病，以及作为相应的氧化硫堇药物（例如，甲基硫堇，MTC）的前药。

公开(公告)号：US08691979B2

公开(公告)日：2014-04-08

申请号：US13318907

申请日：2010-05-11

Applicant: Christopher Paul Larch ,  John Mervyn David Storey ,  Craig Williamson ,  Colin Marshall ,  Steven John Kemp

Inventor： Christopher Paul Larch ,  John Mervyn David Storey ,  Craig Williamson ,  Colin Marshall ,  Steven John Kemp

IPC: C07D279/18 ,  A61K31/5415

CPC classification number: C07D279/18 ,  C07C381/02

Abstract: Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).

Abstract translation: 描述了合成和纯化包括甲基硫堇（MTC）（也称为亚甲基蓝）的某些3,7-二氨基吩噻嗪-5-肟化合物（本文称为“二氨基吩噻嗪鎓化合物”）的方法。 在一个实施方案中，该方法包括以下步骤：顺序：硫代磺酸形成（TSAF）; 氧化偶联（OC）; 和闭环（RC）。 还描述了用于医学治疗和诊断方法等的例如用于tau蛋白病或阿尔茨海默氏病（AD）的所得化合物和包含它们的组合物（例如片剂，胶囊）。

公开(公告)号：US08663760B2

公开(公告)日：2014-03-04

申请号：US13029788

申请日：2011-02-17

Applicant: Alastair Hugh Servante ,  Gary Power ,  Colin Marshall

Inventor： Alastair Hugh Servante ,  Gary Power ,  Colin Marshall

IPC: B32B27/36

CPC classification number: B41M5/52 ,  B41M5/504 ,  B41M5/506 ,  B41M5/508 ,  B41M5/5254 ,  B41M5/5281 ,  B41M7/0081 ,  C08J7/047 ,  C08J2451/00 ,  Y10T428/1352 ,  Y10T428/24802 ,  Y10T428/24851 ,  Y10T428/24893 ,  Y10T428/25 ,  Y10T428/254 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/2848 ,  Y10T428/31551 ,  Y10T428/31573 ,  Y10T428/31667 ,  Y10T428/31678 ,  Y10T428/31699 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31797 ,  Y10T428/31855 ,  Y10T428/31906 ,  Y10T428/31913 ,  Y10T428/31928 ,  Y10T428/31935 ,  Y10T428/31938 ,  Y10T428/31993 ,  Y10T442/20

Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.

公开(公告)号：US20130315992A1

公开(公告)日：2013-11-28

申请号：US13984841

申请日：2011-08-15

Applicant: Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

Inventor： Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Colin Marshall ,  Karrar Ahmad Khan

IPC: C07D279/20 ,  C07C309/30 ,  A61K9/28 ,  C07C309/35 ,  A61K9/20 ,  C07C309/04 ,  C07C309/05

CPC classification number: A61K31/5415 ,  A61K9/0053 ,  A61K9/2095 ,  A61K9/2893 ,  A61L2/0052 ,  C07C303/32 ,  C07C309/04 ,  C07C309/05 ,  C07C309/30 ,  C07C309/35 ,  C07D279/20 ,  Y02A50/393 ,  Y02A50/411

Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

Abstract translation: 本发明涉及通式（I）的化合物：其中：R 1和R 9各自独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R 3NA和R 3NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H，C 1-4烷基，C 2-4链烯基和卤代C 1-4烷基; 并且其中：RA和RB各自独立地选自：C 1-4烷基，卤代C 1-4烷基和C 6-10芳基; 或RA和RB连接形成选自以下的基团：C 1-6亚烷基和C 6-10亚芳基; 和其药学上可接受的盐，其可用于治疗例如阿尔茨海默氏病。 在其它方面，本发明还涉及3,7-二氨基-10H-吩噻嗪鎓盐的新配方。

公开(公告)号：US08440821B2

公开(公告)日：2013-05-14

申请号：US13149164

申请日：2011-05-31

Applicant: Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

Inventor： Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

IPC: C07D279/28

CPC classification number: A61K31/5415 ,  C07D279/18 ,  C07D279/20

Abstract: Described is a method for the synthesis and/or purification of a high purity diaminophenothiazinium compound of the following formula: characterized by a purity of greater than 98% and less than 1% Azure B, 0.15% Azure A, 0.15% Azure C and 0.05% Methylene Violet Bernthsen (MVB), as impurities. Also described are related high purity compounds, compositions, and methods of using such compounds and compositions. The compounds and compositions are useful in the treatment of diseases caused by tau aggregation, such as Alzheimer's disease and other dementias, and infection.

Abstract translation: 描述了用于合成和/或纯化下式的高纯度二氨基吩噻嗪鎓化合物的方法：其特征在于纯度大于98％且小于1％的Azure B，0.15％的Azure A，0.15％的Azure C和0.05 ％亚甲基紫伯氏（MVB），作为杂质。 还描述了相关的高纯度化合物，组合物和使用这些化合物和组合物的方法。 化合物和组合物可用于治疗由tau聚集引起的疾病，例如阿尔茨海默病和其他痴呆以及感染。

公开(公告)号：US08256434B2

公开(公告)日：2012-09-04

申请号：US12854233

申请日：2010-08-11

Applicant: Paul Watters ,  Colin Marshall

Inventor： Paul Watters ,  Colin Marshall

IPC: A24B15/28

CPC classification number: A24B15/28 ,  A24C5/56 ,  A24D1/02 ,  A24D3/04 ,  A24D3/06 ,  A24D3/068

Abstract: The present invention concerns an at least partially transparent cigarette filter tipping film comprising a biodegradable substrate, and softener in an amount of less than 25% by weight of the biodegradable substrate, and a cigarette filter comprising a filtration material encased in a cylinder of the said tipping film.

Abstract translation: 本发明涉及一种至少部分透明的卷烟过滤嘴，其包括可生物降解的基质和小于生物降解性基质重量的25重量％的软化剂，以及卷烟过滤嘴，其包括被包封在所述 翻转胶片

公开(公告)号：US20120135650A1

公开(公告)日：2012-05-31

申请号：US13206232

申请日：2011-08-09

Applicant: Alastain Hugh SERVANTE ,  Gary Power ,  Colin Marshall

Inventor： Alastain Hugh SERVANTE ,  Gary Power ,  Colin Marshall

IPC: B32B27/06 ,  C08K5/11 ,  B32B29/06 ,  B32B18/00 ,  B32B5/02 ,  B32B15/04

CPC classification number: B41M5/52 ,  B41M5/504 ,  B41M5/506 ,  B41M5/508 ,  B41M5/5254 ,  B41M5/5281 ,  B41M7/0081 ,  C08J7/047 ,  C08J2451/00 ,  Y10T428/1352 ,  Y10T428/24802 ,  Y10T428/24851 ,  Y10T428/24893 ,  Y10T428/25 ,  Y10T428/254 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/2848 ,  Y10T428/31551 ,  Y10T428/31573 ,  Y10T428/31667 ,  Y10T428/31678 ,  Y10T428/31699 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31797 ,  Y10T428/31855 ,  Y10T428/31906 ,  Y10T428/31913 ,  Y10T428/31928 ,  Y10T428/31935 ,  Y10T428/31938 ,  Y10T428/31993 ,  Y10T442/20

Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.

Abstract translation: 本发明涉及包括基底和至少表面层的可印刷膜，所述层覆盖所述基底的至少一个表面并且包含水分散性聚合物和烯属不饱和化合物; 涉及制造这种膜的方法; 印刷膜，特别是从这种可印刷膜获得的印刷标签。

公开(公告)号：US20110118242A1

公开(公告)日：2011-05-19

申请号：US13011797

申请日：2011-01-21

Applicant: Claude Michel WISCHIK ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

Inventor： Claude Michel WISCHIK ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

IPC: A61K31/5415 ,  A61P25/28

CPC classification number: C07D279/20 ,  A61K31/5415 ,  A61K49/0002 ,  A61K49/003 ,  A61K51/0465 ,  G01N33/6896 ,  G01N2800/2835 ,  Y02A50/393 ,  Y02A50/411

Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of the following formula: wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methylthioninium chloride, MTC).

Abstract translation: 本发明一般涉及吩噻嗪化合物领域，更具体地涉及某些稳定还原的吩噻嗪化合物，具体地，下列通式的某些3,7-二氨基-10H-吩噻嗪（DAPTZ）化合物：其中：R 1和R 9各自为 独立选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R3NA和R3NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; HX1和HX2各自独立地是质子酸; 及其药学上可接受的盐，溶剂化物和水合物。 这些化合物可用作药物，例如用于治疗tau蛋白病，例如阿尔茨海默氏病，以及作为相应的氧化硫堇药物（例如，甲基硫堇，MTC）的前药。