公开(公告)号：US20100255107A1

公开(公告)日：2010-10-07

申请号：US12818924

申请日：2010-06-18

Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K9/50 ,  A61K8/11 ,  A61K31/235 ,  A61K8/37 ,  A61K31/7048 ,  A61P17/06 ,  A61P17/10 ,  A61P29/00 ,  A61P31/12 ,  A61P31/04 ,  A61Q90/00 ,  A61K8/60

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/37 ,  A61K8/38 ,  A61K8/602 ,  A61K8/671 ,  A61K9/501 ,  A61K9/5031 ,  A61K9/5115 ,  A61K9/5138 ,  A61K2800/412 ,  A61K2800/75 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/945

Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.

Abstract translation: 一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。 微胶囊的直径约为0.1至100微米。 每个微胶囊的核心包含至少一种活性成分，并被包封在微胶囊壳内。 壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。 该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

公开(公告)号：US07109993B2

公开(公告)日：2006-09-19

申请号：US10279097

申请日：2002-10-24

Applicant: Shmuel Peleg ,  Ran Cohen ,  David Avnir

Inventor： Shmuel Peleg ,  Ran Cohen ,  David Avnir

IPC: G06T15/00

CPC classification number: H04N5/222 ,  G06T9/001 ,  G11B27/028 ,  G11B27/034 ,  G11B27/10 ,  Y10S345/949

Abstract: A method for automated computerized audio visual dubbing of a movie comprises (i) generating a three-dimensional head model of an actor in a movie, the head model being representative of specific facial features of the actor, and (ii) generating a three-dimensional head model of a dubber making target sounds for the actor, the dubber head model being representative of specific facial features of the dubber, as the target sounds are made. The method also comprises modifying at least a portion of the specific facial features of the actor head model according to the dubber head model such that the actor appears to be producing target sounds made by the dubber.

公开(公告)号：US06238650B1

公开(公告)日：2001-05-29

申请号：US09318828

申请日：1999-05-26

Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K742

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/445 ,  A61K2800/412 ,  A61Q17/04 ,  Y10S514/962

Abstract: The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the ultraviolet absorbers reduces or even prevents the contact between the sunscreen compounds and the human tissue, thus reducing various adverse effects that are associated with the use of sunscreens, such as photoallergy and phototoxicity, and makes the composition safer for use. The encapsulation also reduces or even prevents cross reactivity between the sunscreen compounds and the packaging material and between the sunscreen compounds and any other component present in the composition, thus enhance the compositions stability. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.

Abstract translation: 本发明一般涉及安全和稳定的防晒组合物，其包含至少一种防霉活性成分，其形式为在任何可接受的化妆品载体中包封紫外线吸收化合物的惰性溶胶 - 凝胶微胶囊形式。 根据本发明的组合物可以包含几种可以包封在相同溶胶 - 凝胶微胶囊或不同胶囊中的紫外线吸收剂。 紫外线吸收剂的封装减少或甚至防止防晒化合物与人体组织之间的接触，从而减少与防晒剂的使用相关的各种不利影响，例如光过敏和光毒性，并使组合物更安全地使用。 封装还降低或甚至防止防晒化合物和包装材料之间以及防晒化合物和组合物中存在的任何其它组分之间的交叉反应性，从而增强组合物的稳定性。 可以通过选择合适的溶胶 - 凝胶前体和合适的反应条件来控制溶胶 - 凝胶微胶囊的疏水性/亲水性，并且可以选择与化妆品相容以用于防晒组合物，因此本发明有利于 将复合溶胶 - 凝胶包胶的防晒剂容易地并入包括无油组合物的所有类型的化妆品载体中，没有必要的加热步骤或高剪切力。 本发明的防晒组合物可以以任何所需的比例包含任何可接受的UVA和/或UVB吸收化合物，以获得所需的累积紫外线屏蔽谱。

公开(公告)号：US5650311A

公开(公告)日：1997-07-22

申请号：US266441

申请日：1994-06-28

Applicant: David Avnir ,  Michael Ottolenghi ,  Sergei Braun ,  Rivka Zusman

Inventor： David Avnir ,  Michael Ottolenghi ,  Sergei Braun ,  Rivka Zusman

IPC: C07K16/00 ,  B01J20/281 ,  B01J20/283 ,  B01J20/291 ,  C03B8/02 ,  C03C4/00 ,  C07K1/14 ,  C12N11/04 ,  C12N11/14 ,  C12P1/00 ,  C12Q1/00 ,  G01N21/77 ,  G01N27/327 ,  G01N30/02 ,  G01N30/88 ,  G01N30/92 ,  G01N31/22 ,  G01N33/543 ,  G01N33/552 ,  G01N33/68 ,  G01N33/84 ,  G01N1/00 ,  A61K9/50 ,  B01J13/18

CPC classification number: G01N33/6869 ,  B01J20/283 ,  B01J20/291 ,  C03C4/0007 ,  C12N11/14 ,  C12P1/00 ,  G01N31/22 ,  G01N33/5436 ,  G01N33/552 ,  G01N33/84 ,  B01J2220/54 ,  G01N2030/484 ,  G01N30/02 ,  G01N30/92 ,  Y02P20/588 ,  Y10S514/944 ,  Y10S514/965 ,  Y10S530/811 ,  Y10T428/2989 ,  Y10T436/10

Abstract: A metod is proposed of obtaining a chemical interaction between at least one reagent trapped in sol-gel glass by doping it with the reagent(s), and diffusible solutes or components in an adjacent liquid or gas phase. The reagents, the solutes or the components can be any organic or inorganic compounds or materials of biological origins including enzymes. The doped sol-gel glass in various forms may be useful as analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, or other detection device.

Abstract translation: 提出了通过将其与试剂掺杂，以及相邻液相或气相中的可扩散溶质或组分，获得捕获在溶胶 - 凝胶玻璃中的至少一种试剂之间的化学相互作用的方法。 试剂，溶质或组分可以是任何有机或无机化合物或生物来源的材料，包括酶。 各种形式的掺杂溶胶 - 凝胶玻璃可用作分析测试，色谱介质，传感器，催化剂或生物催化剂，电极或酶电极或其他检测装置。

公开(公告)号：US5371018A

公开(公告)日：1994-12-06

申请号：US953358

申请日：1992-09-30

Applicant: David Avnir ,  Michael Ottolenghi ,  Ovadia Lev

Inventor： David Avnir ,  Michael Ottolenghi ,  Ovadia Lev

IPC: B01J20/283 ,  B01J20/291 ,  C03C4/00 ,  G01N30/02 ,  G01N30/92 ,  G01N31/22 ,  G01N33/543 ,  G01N33/552 ,  G01N33/68 ,  G01N33/84 ,  G01N33/20

CPC classification number: B01J20/291 ,  B01J20/283 ,  C03C4/0007 ,  G01N31/22 ,  G01N33/5436 ,  G01N33/552 ,  G01N33/6869 ,  G01N33/84 ,  B01J2220/54 ,  G01N30/02 ,  G01N30/92

Abstract: A process for qualitative or quantitative determination of a reactive chemical contained in a liquid sample by forming doped sol-gel glass pellets from a metal alkoxide, arranging the porous doped sol-gel glass pellets in a glass tube, contacting a liquid sample containing a reactive chemical with the porous doped sol-gel glass pellets contained in the glass tube, and measuring a length of a stained portion of the glass tube resulting from a color change in the sol-gel glass pellets. The sol-gel glass pellets are formed by a gelling step conducted at room temperature in the presence of a colorimetric reagent dopant which produces a color change in the presence of the reactive chemical, and a drying step conducted at not greater than 41.degree. C. The doped sol-gel glass pellets contain the colorimetric reagent dopant encapsulated therein and the encapsulated colorimetric reagent dopant is color changeable in the presence of the reactive chemical in the pores of the doped sol-gel glass pellets.

Abstract translation: 一种用于通过从金属醇盐形成掺杂的溶胶 - 凝胶玻璃颗粒来定性或定量测定液体样品中所含的反应性化学品的方法，将多孔掺杂的溶胶 - 凝胶玻璃颗粒放置在玻璃管中，使含有反应性 与玻璃管中所含的多孔掺杂的溶胶 - 凝胶玻璃颗粒化学，并测量由溶胶 - 凝胶玻璃颗粒中的颜色变化导致的玻璃管的染色部分的长度。 溶胶 - 凝胶玻璃颗粒通过在室温下在存在反应性化学物质的情况下产生颜色变化的比色试剂掺杂剂的存在下进行胶凝化步骤而形成，并且干燥步骤在不大于41℃的条件下进行。 掺杂的溶胶 - 凝胶玻璃颗粒包含其中包含的比色试剂掺杂剂，并且包被的比色试剂掺杂剂在掺杂的溶胶 - 凝胶玻璃颗粒的孔隙中的反应性化学物的存在下是可颜色变化的。

公开(公告)号：US08039020B2

公开(公告)日：2011-10-18

申请号：US12818924

申请日：2010-06-18

Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K9/14 ,  A61K9/00 ,  A61K31/07 ,  A61K31/19 ,  A61K31/327

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/37 ,  A61K8/38 ,  A61K8/602 ,  A61K8/671 ,  A61K9/501 ,  A61K9/5031 ,  A61K9/5115 ,  A61K9/5138 ,  A61K2800/412 ,  A61K2800/75 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/945

Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.

Abstract translation: 一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。 微胶囊的直径约为0.1至100微米。 每个微胶囊的核心包含至少一种活性成分，并被包封在微胶囊壳内。 壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。 该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

公开(公告)号：US20070165022A1

公开(公告)日：2007-07-19

申请号：US11498321

申请日：2006-08-01

Applicant: Shmuel Peleg ,  Ran Cohen ,  David Avnir

Inventor： Shmuel Peleg ,  Ran Cohen ,  David Avnir

IPC: G06T15/00

CPC classification number: G06T13/40 ,  G11B27/036

Abstract: A method for automated computerized audio visual dubbing of a movie comprises (i) generating a three-dimensional head model of an actor in a movie, the head model being representative of specific facial features of the actor, and (ii) generating a three-dimensional head model of a dubber making target sounds for the actor, the dubber head model being representative of specific facial features of the dubber, as the target sounds are made. The method also comprises modifying at least a portion of the specific facial features of the actor head model according to the dubber head model such that the actor appears to be producing target sounds made by the dubber.

Abstract translation: 一种用于电影的自动计算机化视听配音的方法包括：（i）生成电影中的演员的三维头部模型，所述头部模型代表所述演员的特定面部特征，以及（ii） 作为目标声音，作为目标声音的哑铃制作目标的三维头部模型声音为哑铃头模型，代表了嘟嘟声的特定面部特征。 所述方法还包括根据所述混音头模型修改所述演员头部模型的所述特定面部特征的至少一部分，使得所述演员似乎产生由所述嘟嘟声产生的目标声音。

公开(公告)号：US20050255989A1

公开(公告)日：2005-11-17

申请号：US10525512

申请日：2003-08-25

Applicant: Naohiro Soga ,  Kazuki Nakanishi ,  David Avnir

Inventor： Naohiro Soga ,  Kazuki Nakanishi ,  David Avnir

IPC: B01J21/08 ,  B01J31/16 ,  B01J37/03 ,  B01J31/00

CPC classification number: B01J37/036 ,  B01J21/08 ,  B01J31/1675 ,  B01J37/033 ,  B01J2531/80

Abstract: It is provided a monolithic reactive porous support with efficiency and performance better than a particulate support used in a batch method requiring a liquid-solid separation process or a filling column method requiring a high pressure for liquid supply. In a solution containing a starting material having a reactive site, a precursor of a monolithic porous gel formed of silica, a metal oxide, or an organic-inorganic hybrid composition is reacted. Accordingly, sol-gel transformation and phase separation are induced at the same time to form a gel of the composition having continuous pores with a diameter of 100 nm or greater.

Abstract translation: 提供了一种整体反应性多孔载体，其效率和性能优于需要液固分离方法的批式方法或需要高压用于液体供应的填充柱方法中使用的颗粒载体。 在含有具有反应性位点的原料的溶液中，由二氧化硅，金属氧化物或有机 - 无机杂化组合物形成的整体多孔凝胶的前体反应。 因此，同时诱导溶胶 - 凝胶转化和相分离，形成具有直径为100nm以上的连续孔的组合物的凝胶。

公开(公告)号：US06468509B2

公开(公告)日：2002-10-22

申请号：US09840456

申请日：2001-04-24

Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K742

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/445 ,  A61K2800/412 ,  A61Q17/04 ,  Y10S514/962

Abstract: The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.

公开(公告)号：US5300564A

公开(公告)日：1994-04-05

申请号：US637873

申请日：1991-01-08

Applicant: David Avnir ,  Michael Ottolenghi ,  Sergei Braun ,  Rivka Zusman

Inventor： David Avnir ,  Michael Ottolenghi ,  Sergei Braun ,  Rivka Zusman

IPC: C07K16/00 ,  B01J20/281 ,  B01J20/283 ,  B01J20/291 ,  C03B8/02 ,  C03C4/00 ,  C07K1/14 ,  C12N11/04 ,  C12N11/14 ,  C12P1/00 ,  C12Q1/00 ,  G01N21/77 ,  G01N27/327 ,  G01N30/02 ,  G01N30/88 ,  G01N30/92 ,  G01N31/22 ,  G01N33/543 ,  G01N33/552 ,  G01N33/68 ,  G01N33/84 ,  B01D53/00 ,  G01N21/00 ,  G01N33/00

CPC classification number: G01N33/6869 ,  B01J20/283 ,  B01J20/291 ,  C03C4/0007 ,  C12N11/14 ,  C12P1/00 ,  G01N31/22 ,  G01N33/5436 ,  G01N33/552 ,  G01N33/84 ,  B01J2220/54 ,  G01N2030/484 ,  G01N30/02 ,  G01N30/92 ,  Y02P20/588 ,  Y10S514/944 ,  Y10S514/965 ,  Y10S530/811 ,  Y10T428/2989 ,  Y10T436/10

Abstract: A method is proposed of obtaining a chemical interaction between at least one reagent trapped in sol-gel glass by doping it with the reagent, and diffusible solutes or components in an adjacent liquid or gas phase. The reagents, the solutes or the components can be any organic or inorganic compounds or materials of biological origin including enzymes. The doped sol-gel glass in various forms may be useful as analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, or other detection device.