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公开(公告)号：US6149623A
公开(公告)日：2000-11-21
申请号：US114063
申请日：1998-07-13
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： A61J1/2096 , A61F13/0203 , A61J1/2089 , A61L15/225 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2058 , A61J1/2065 , A61J1/2086
摘要： A system is provided for providing syringes filled with pharmaceuticals whose components must be stored separately, using an active ingredient in a pharmaceutical vial, a diluent in a protosyringe such as a bottomless vial or a cartridge, and a combiner assembly which enables the content of the pharmaceutical vial to be transferred into the protosyringe and converts it into a ready-to-use syringe on activation. The combined assembly included a tubular body having recesses at opposite ends for receiving capped ends of the vial and the protosyringe, and a hub and needle assembly between penetrable sheaths or shields which acts on activation of the assembly to enable the transfer and conversion referred to above. Components of the system may also be used to convert protosyringes and pharmaceutical vials containing pharmaceuticals into delivery systems.
摘要翻译： 提供一种用于提供充满药物的注射器的系统，其组件必须分开储存，使用药物小瓶中的活性成分，诸如无底小瓶或药筒的前列腺素中的稀释剂，以及组合器组件， 将药物小瓶转移到前列腺素并在活化时将其转化成即用型注射器。 组合的组件包括管状体，其具有在相对端处的凹部，用于接收小瓶和前列腺体的封端端，以及在可穿透护套或屏蔽之间的毂和针组件，其作用于组件的启动以实现上述转移和转换 。 该系统的组分也可用于将含有药物的衍生物和药物瓶转化成递送系统。
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公开(公告)号：US5927136A
公开(公告)日：1999-07-27
申请号：US964691
申请日：1997-11-06
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： H01M2/0225 , B21D31/00 , B21J5/12 , H01M4/70 , H01M6/005 , Y10T29/49108
摘要： The internal tubular surface of a collector can for a battery cell is processed by planing or ploughing an array of discrete portions of material out of the thickness of the can wall without penetrating the can so as to lift these portions inwardly of the surfaces, while leaving them attached to the can, to positions where they present surfaces facing both towards and away from the can. The lifted portions extend the internal surface of the can and provide couples into the active material of the cell which both physically and electrically bond the material to the extended surface. The process makes use of a segmental array of cutting elements advanced axially into the can, then moved radially to penetrate the can surface and axially or circumferentially through a cutting stroke to raise non-detached shavings on a segment of the internal surface of the can, and then withdrawn using reverse motions. Multiple segmental arrays may be used simultaneously, or the same array may be used sequentially on different segments of the surface.
摘要翻译： 用于电池单元的集电器的内部管状表面通过在不渗透罐的情况下刨削或刨削不同于罐壁厚度的离散部分的材料来处理，以便将这些部分提升到表面的内部，同时留下 它们附着在罐上，到位于其表面朝向和远离罐的表面。 提升的部分延伸罐的内表面并且将配对提供到电池的活性材料中，其将材料物理和电连接到延伸表面。 该方法利用沿轴向进入罐的切割元件的分段阵列，然后径向移动以穿透罐表面并且轴向或周向地穿过切割行程，以在罐的内表面的一段上提升非分离的切屑， 然后使用反向运动撤回。 可以同时使用多个分段阵列，或者可以在表面的不同部分上顺序使用相同的阵列。
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公开(公告)号：US5554125A
公开(公告)日：1996-09-10
申请号：US245132
申请日：1994-05-17
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： A61J1/2096 , A61J1/062 , A61J1/2089 , A61M5/28 , A61M5/284 , A61M5/315 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2075 , A61M2005/3139 , A61M5/1452 , A61M5/31505
摘要： A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When a flexible extension of the piston is coupled with a tubular plunger, and an adaptor cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The open bottom of the vial is configured so as not to interfere with handling of the vials by conventional vial sterilizing, filling and capping machinery, and may be formed so as to provide an internal shoulder which will secure a piston retention member.
摘要翻译： 用于一种或两种组分药物的预充式注射器基于使用含有药物或药物的一种成分的小瓶，该小瓶具有由活塞封闭的开口底部。 当活塞的柔性延伸部与管状柱塞联接时，具有内针和用于针头的外部连接件的适配器盖被放置在小瓶的帽上，后者被转换成预充式注射器。 小瓶的开口底部被配置成不会通过常规的小瓶灭菌，填充和封盖机械干扰小瓶的处理，并且可以形成为提供将固定活塞保持构件的内部肩部。
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14.发明申请Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge 有权用于将容纳第一物质的小瓶的内容物与存储在筒中的第二物质混合的重构系统公开(公告)号：US20080172001A1
公开(公告)日：2008-07-17
申请号：US11974737
申请日：2007-10-16
IPC分类号： A61M5/00
CPC分类号： A61J1/2089 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2055 , A61J1/2065
摘要： A transfer assembly for transfering a fluid to a vial, admixing the same and then returning the fluid to a cartridge, the transfer assembly having a vial gripper located at a first end and a cartridge holder at the second end of an elongated outer housing, a fluid passageway extending between the vial gripper and the cartridge holder with piercing elements being located at respective ends of the fluid passageway. In a preferred embodiment, an adaptor is mounted on the end of the outer housing where the cartridge holder is situated. The adaptor may move from a retracted to an extended position wherein it will surround the needle.
摘要翻译： 一种转移组件，用于将流体转移到小瓶中，将其混合，然后将流体返回到药筒，转移组件具有位于第一端的小瓶夹持器和位于细长外壳体的第二端处的药筒保持器， 流体通道在小瓶夹持器和药筒保持器之间延伸，穿刺元件位于流体通道的相应端部处。 在优选实施例中，适配器安装在外壳的其中盒保持器所在的端部。 适配器可以从缩回移动到延伸位置，其中它将围绕针。
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公开(公告)号：US5401253A
公开(公告)日：1995-03-28
申请号：US180483
申请日：1994-01-12
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： A61M5/1456 , A61M5/1409
摘要： A system for the intravenous infusion of pharmaceuticals uses a syringe assembly, and a flexible tube for connection to a Y-connector in an intravenous drip assembly through which tube diluent fluid may flow from the drip assembly through the connector assembly to the syringe body, and through which diluted, dissolved or suspended pharmaceutical may pass from the syringe body to the Y-connector. The syringe assembly has an elongated body, a piston movable longitudinally within and in sealing engagement with the body, a plunger for insertion into one end of the body to move the piston, a penetrable closure at the other end of the body, and a connector assembly for establishing a passage for liquid between the interior of the body and the tube, the connector assembly comprising first and second cannulas projectable through said penetrable closure, a coupling for establishing connection between the first cannula and the tube, an air valve establishing a controlled connection to the exterior of the connector assembly, and a connection between the second cannula and the air valve.
摘要翻译： 用于静脉内输注药物的系统使用注射器组件和用于连接到静脉滴注组件中的Y型连接器的柔性管，管稀释液可以通过该静脉滴注组件从滴注组件通过连接器组件流动到注射器主体，以及 稀释，溶解或悬浮的药物可以从注射器本体通过Y连接器。 注射器组件具有细长主体，可在主体内纵向移动并且与主体密封接合的活塞，用于插入主体的一端以移动活塞的柱塞，在主体的另一端处的可穿透闭合件，以及连接器 用于在所述主体内部和所述管之间建立用于液体的通道的组件，所述连接器组件包括可穿过所述可穿透闭合件突出的第一和第二插管，用于在所述第一插管和所述管之间建立连接的联接器， 连接到连接器组件的外部，以及第二插管和空气阀之间的连接。
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16.发明授权Vial-based prefilled syringe system for one or two component medicaments 失效一种或两种组分药物的基于样品瓶的预充式注射器系统
公开(公告)号：US4886495A
公开(公告)日：1989-12-12
申请号：US72015
申请日：1987-07-08
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： A61M5/284 , A61M2005/3139 , A61M5/1411 , A61M5/1452 , A61M5/1456
摘要： A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When the piston is coupled with a plunger, and an adapter cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The piston has an axial passage closed by a resealable septum, so that a separate diluent stored in a flexible capsule may be introduced into the vial through the piston by a double ended needle mounted on a further cap applied to the capsule, the further cap being coupled within the tubular interior of the plunger so that the double ended needle penetrates the septum in the piston. The capsule is pushed forward onto the double ended needle when its contents are to be expelled into the vial. The capsule and its cap are then removed and discarded.
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公开(公告)号：US08869635B2
公开(公告)日：2014-10-28
申请号：US13261191
申请日：2010-09-08
CPC分类号： A61J1/2096 , A61J1/1425 , A61J1/201 , A61J1/2051 , B01F13/002 , B01F13/0022 , B01F15/0212 , B01F15/0223
摘要： A transfer device (10) which comprises an outer housing (24), an inner body (26) formed within the housing (24), the inner body (26) having a conduit (66) extending therethrough to provide fluid communication between upper and lower chambers, the conduit (66) having a piercing tip (68) at a lower end, a cap (54)having a top wall and a downwardly extending wall (58), the cap being retained in position such that access cannot be had to the inner body (26), and a pushing member (44) which has at least one leg (48) extending upwardly, the pushing member having an activated position where the leg (48) will extend upwardly to the upper chamber and move the cap (54) such that access may be had to the inner body (26).
摘要翻译： 一种转移装置（10），包括外壳体（24），形成在壳体（24）内部的内部主体（26），内部主体（26）具有延伸穿过其中的导管（66），以提供上部和 所述导管（66）在下端具有穿刺尖端（68），具有顶壁和向下延伸的壁（58）的帽（54），所述帽保持在适当的位置，使得不能进入 以及具有向上延伸的至少一个腿部（48）的推动构件（44），所述推动构件具有启动位置，其中所述腿部（48）将向上延伸到所述上部腔室并且使所述推动构件 帽（54），使得可能对内部主体（26）进行接近。
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公开(公告)号：US20140000738A1
公开(公告)日：2014-01-02
申请号：US13261729
申请日：2012-03-05
IPC分类号： A61J1/20
CPC分类号： A61J1/20 , A61J1/201 , A61J1/2096 , Y10T137/9029
摘要： A transfer device for pharmaceuticals comprising a housing which has an open bottom permitting insertion of a vial within the housing, a piercing member mounted within the housing and having an interior passageway formed therein, a connector for a syringe located on top of the housing, and a moveable member mounted within the housing, the moveable member being moveable from a first position preventing access to the piercing member and a second position permitting access to the piercing member when the vial is inserted in the housing.
摘要翻译： 一种用于药物的转移装置，包括：外壳，其具有敞开的底部，允许小瓶在壳体内插入;刺穿构件，其安装在壳体内并具有形成在其中的内部通道;位于壳体顶部的注射器连接器;以及 安装在所述壳体内的可移动构件，所述可移动构件可从第一位置移动，从而防止进入所述穿孔构件;以及当所述小瓶插入所述壳体中时允许进入所述刺穿构件的第二位置。
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公开(公告)号：USD690411S1
公开(公告)日：2013-09-24
申请号：US29374313
申请日：2011-07-27
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公开(公告)号：US08523807B2
公开(公告)日：2013-09-03
申请号：US12009783
申请日：2008-01-22
IPC分类号： A61M37/00
CPC分类号： A61M5/385 , A61J1/201 , A61J1/2055 , A61J1/2096
摘要： A transfer and mixing device which utilizes a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.
摘要翻译： 一种利用旁路药筒和注射器的转运和混合装置。 在旁路盒中混合干燥组分和稀释剂之后，可以将混合物送入注射器，该注射器包括其中具有流体通道的注射器柱塞，其中覆盖通道的疏水膜。 混合物可以通过小孔在旁路筒和注射器之间来回传递以实现混合，特别是在保持悬浮的微球的情况下。
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