公开(公告)号：US07135286B2

公开(公告)日：2006-11-14

申请号：US10107508

申请日：2002-03-26

申请人： Bradley A. Margus ,  David R. Cox ,  Stephen P. A. Fodor

发明人： Bradley A. Margus ,  David R. Cox ,  Stephen P. A. Fodor

IPC分类号： C12Q1/68

CPC分类号： G06F19/18 ,  G06Q50/22 ,  G06Q50/24 ,  G06Q99/00 ,  Y02A90/22

摘要： Improved pharmaceutical and diagnostic business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic development.

公开(公告)号：US06406847B1

公开(公告)日：2002-06-18

申请号：US09271055

申请日：1999-03-17

申请人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

发明人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

IPC分类号： C12Q168

CPC分类号： C12Q1/6827 ,  C12Q1/6897 ,  C12Q2600/156

摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

公开(公告)号：US08462959B2

公开(公告)日：2013-06-11

申请号：US11867622

申请日：2007-10-04

申请人： Paul J. Costa ,  David R. Cox ,  Benjamin A. Bard

发明人： Paul J. Costa ,  David R. Cox ,  Benjamin A. Bard

IPC分类号： H03B29/00

CPC分类号： G10K11/16 ,  G06F1/20 ,  H05K7/20209

摘要： One embodiment of the present invention provides a system that manages the acoustic noise produced by a device. During operation, the system receives a set of acoustic characteristics for the device. The system then uses these acoustic characteristics to estimate the acoustic noise being generated by the device. Next, the system uses the estimated acoustic noise to adjust a setting in the device to manage the acoustic noise produced by the device.

摘要翻译： 本发明的一个实施例提供一种管理由设备产生的声学噪声的系统。 在操作期间，系统接收一组该设备的声学特性。 然后，系统使用这些声学特性来估计由设备产生的声学噪声。 接下来，系统使用估计的声学噪声来调整设备中的设置以管理由设备产生的声学噪声。

公开(公告)号：US07153652B2

公开(公告)日：2006-12-26

申请号：US10081771

申请日：2002-02-20

申请人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

发明人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02

CPC分类号： C40B40/02 ,  C12N15/1037 ,  C12N15/64 ,  C12N15/70 ,  C12Q1/6827 ,  C12Q1/6897 ,  C12Q2600/156 ,  C12Q2521/507 ,  C12Q2521/514

摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and-lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

公开(公告)号：US06955883B2

公开(公告)日：2005-10-18

申请号：US10402839

申请日：2003-03-26

申请人： Bradley A. Margus ,  David R. Cox ,  Stephen P. A. Fodor

发明人： Bradley A. Margus ,  David R. Cox ,  Stephen P. A. Fodor

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/711 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P3/10 ,  A61P31/04 ,  A61P35/00 ,  A61P37/02 ,  C12Q1/68 ,  G01N20060101 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00 ,  G06Q50/22 ,  G06Q50/24

CPC分类号： G06F19/18 ,  G06Q50/22 ,  G06Q50/24 ,  G06Q99/00 ,  Y02A90/22

摘要： Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.

摘要翻译： 披露了改进的生命科学业务系统和方法。 一个或多个基因组扫描单核苷酸多态性。 将多态性分配给单倍型区段，并且来自单倍型区段的代表性SNP用于药物和诊断发展的关联研究。

公开(公告)号：US06897025B2

公开(公告)日：2005-05-24

申请号：US10042819

申请日：2002-01-07

申请人： David R. Cox ,  Bradley A. Margus ,  Nila Patil

发明人： David R. Cox ,  Bradley A. Margus ,  Nila Patil

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6827 ,  C12Q2565/125 ,  C12Q2565/501

摘要： Improved systems and methods for performing genetic analyses. Full genomic DNA scans are performed on the genetic DNA from a plurality of individuals to identify genetic variants. For those variants, but not based on a full genetic DNA scan, the variants alone are scanned in additional individuals to identify blocks of the variants that tend to be inherited together.

摘要翻译： 改进的用于进行遗传分析的系统和方法。 对来自多个个体的遗传DNA进行全基因组DNA扫描，以鉴定遗传变异。 对于这些变体，但不是基于完整的基因DNA扫描，单独的变体被扫描在另外的个体中以鉴定易于一起遗传的变体块。

公开(公告)号：US06709827B2

公开(公告)日：2004-03-23

申请号：US10072047

申请日：2002-02-08

申请人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

发明人： David R. Cox ,  Malek Faham ,  Siamak Baharloo

IPC分类号： C12Q168

CPC分类号： C12Q1/6827 ,  C12Q1/6897 ,  C12Q2600/156

摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

摘要翻译： 用于DNA变异检测的新方法的不匹配修复检测（MRD）利用细菌通过标记基因的表达变化来检测错配。 将待筛选的DNA片段克隆到两个MRD质粒中，并用这些构建体的异源双链体转化细菌。 得到的菌落在不存在错配的情况下表达标记基因，并且在存在失配的情况下缺乏表达。 MRD能够检测DNA的10 kb内的单一错配。 此外，MRD可以同时分析许多片段，为高通量基因分型和突变检测提供了强大的方法。

公开(公告)号：US08704833B2

公开(公告)日：2014-04-22

申请号：US11810487

申请日：2007-06-06

申请人： David R. Cox ,  Derek J. DiCarlo ,  Paul J. Costa

发明人： David R. Cox ,  Derek J. DiCarlo ,  Paul J. Costa

IPC分类号： G06F15/00

CPC分类号： H04N5/44 ,  G06F3/14 ,  G09G5/003 ,  G09G5/006 ,  G09G5/36 ,  G09G2330/021 ,  G09G2330/026 ,  G09G2330/027 ,  G09G2370/047 ,  G09G2370/12 ,  G09G2370/20 ,  G09G2370/22 ,  H04N21/4143 ,  H04N21/43632 ,  H04N21/43635 ,  H04N21/44231 ,  H04N21/4436

摘要： A system that displays a video signal on a display for a computer system is presented. During operation, the system receives a signal to switch from displaying a video signal from an internal video source to displaying a video signal from an external video source. In this system, the internal and external video sources are coupled to a bi-directional video port for the computer system, wherein the internal video source generates an output video signal and the external video source generates an input video signal. The system then determines whether the external video source is coupled to the bi-directional video port. If so, the system couples the external video source to the display and determines whether the external video source is a valid video source. If the external video source is a valid video source, the system displays the video signal from the external video source on the display.

摘要翻译： 提出了在计算机系统的显示器上显示视频信号的系统。 在操作期间，系统接收信号以从显示来自内部视频源的视频信号切换到显示来自外部视频源的视频信号。 在该系统中，内部和外部视频源耦合到用于计算机系统的双向视频端口，其中内部视频源产生输出视频信号，并且外部视频源产生输入视频信号。 然后，系统确定外部视频源是否耦合到双向视频端口。 如果是这样，系统将外部视频源耦合到显示器，并确定外部视频源是否是有效的视频源。 如果外部视频源是有效的视频源，系统会在显示屏上显示来自外部视频源的视频信号。

公开(公告)号：US20130326251A1

公开(公告)日：2013-12-05

申请号：US13628000

申请日：2012-09-26

申请人： Fiyinfolu O. Adewale ,  Paul J. Costa ,  David R. Cox ,  Michael J. Giles ,  Steven I. Kuo ,  Nicholas W. Ruhter ,  Steven J. Sfarzo

发明人： Fiyinfolu O. Adewale ,  Paul J. Costa ,  David R. Cox ,  Michael J. Giles ,  Steven I. Kuo ,  Nicholas W. Ruhter ,  Steven J. Sfarzo

IPC分类号： G06F1/26 ,  G06F1/32

CPC分类号： G06F1/3253 ,  G06F1/266 ,  G06F1/3215 ,  G06F1/3234

摘要： A method and apparatus for recovering from a low power state in a computing system is disclosed. In one embodiment of the method, the computing system enters the low power state from a standard power state after an activity detector indicates a user controlled peripheral device connected to the computer system has been inactive for a period of time. To enter the low power state, the method disconnects the user controlled peripheral device from a host controller, while continuing to supply power to the user controlled peripheral device and shutting off power to the host controller. The method returns the computer system to the standard power state when the activity detector indicates the user controlled peripheral device has become active. To return to the standard power state, power is restored to the host controller and the user controlled peripheral device is reconnected to the host controller.

公开(公告)号：US20090186347A1

公开(公告)日：2009-07-23

申请号：US12152141

申请日：2008-05-09

申请人： David R. Cox ,  Kelly A. Frazer ,  David A. Hinds ,  Craig L. Hyde ,  John F. Thompson

发明人： David R. Cox ,  Kelly A. Frazer ,  David A. Hinds ,  Craig L. Hyde ,  John F. Thompson

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/172

摘要： Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided.

摘要翻译： 提供多态性与代谢综合征之间的相关性，胰岛素抵抗，肥胖，高血压，血脂异常，糖尿病和/或心肌梗死。 提供诊断和治疗代谢综合征，胰岛素抵抗，肥胖，高血压，血脂异常，糖尿病和/或心肌梗死的方法。 提供了代谢综合征，胰岛素抵抗，肥胖，高血压，血脂异常，糖尿病和/或心肌梗塞的诊断和治疗的系统和试剂盒。