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    Polymeric supports
    12.
    发明授权
    Polymeric supports 失效
    聚合物载体

    公开(公告)号：US5403902A

    公开(公告)日：1995-04-04

    申请号：US183063

    申请日：1994-01-18

    申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

    发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

    IPC分类号： A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/48 ,  C08F20/58 ,  C12N11/08 ,  C08F26/06 ,  C08F220/10 ,  C08F220/54

    CPC分类号： C12N11/08 ,  A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00 ,  C08F8/48

    摘要： Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional supports have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1, the azlactone functional supports having 0.1 to 99 molar parts of crosslinking monomer incorporated therein.

    摘要翻译： 吖内酯官能聚合物载体是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及酶或其它生物活性载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯官能载体具有下式的单元：其中R 1为H或CH 3，R 2和R 3可独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基，芳基 具有5至12个环原子，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成含有4至 12个环原子，n为0或1的整数，所述吖内酯官能载体中含有0.1至99摩尔份的交联单体。

    Method of coupling ligands onto supports and products produced therefrom
    16.
    发明授权
    Method of coupling ligands onto supports and products produced therefrom 失效
    将配体偶联到载体上并由其制备的产物的方法

    公开(公告)号：US5907016A

    公开(公告)日：1999-05-25

    申请号：US296588

    申请日：1994-08-29

    申请人： William H. Velander ,  Dean S. Milbrath ,  Anuradha Subramanian

    发明人： William H. Velander ,  Dean S. Milbrath ,  Anuradha Subramanian

    IPC分类号： C12P21/00 ,  C07K14/31 ,  C07K16/06 ,  C07K17/00 ,  C07K17/08 ,  C12N9/64 ,  C12N11/00 ,  C07K17/04 ,  C07K17/06 ,  C07K17/10 ,  C07K17/12

    CPC分类号： C12N9/6464 ,  C07K16/065 ,  C07K17/00 ,  C12N11/00 ,  C12Y304/21069

    摘要： A method is disclosed for coupling a ligand within a porous support. The method involves mixing ligand and porous support under conditions sufficient to suppress coupling conditions of the ligand to the porous support while enhancing the relative rate of diffusion, to the rate of reaction, of the ligand into and within the porous support, and then altering the conditions to enhance rapid coupling of the ligand within the porous support. The alteration from diffusion conditions to coupling conditions involves a change in the reaction solution of pH, ionic strength, temperature, coupling competitor, such that a relatively lower Thiele Modulus during diffusion conditions changes to a relatively higher Thiele Modulus during coupling conditions. Derivatized porous supports produced according to the method are also disclosed. The derivatized porous support has enhanced functional efficiency. Derivatized porous supports prepared from azlactone-functional porous supports are also disclosed.

    摘要翻译： 公开了一种在多孔载体内偶联配位体的方法。 该方法包括在足以抑制配体与多孔载体的偶联条件的条件下混合配体和多孔载体，同时增加配体相对于多孔载体中的相对扩散速率，反应速率和多孔载体中的相对速率，然后改变 增强配体在多孔载体内的快速偶联的条件。 从扩散条件到耦合条件的改变涉及pH，离子强度，温度，耦合竞争剂的反应溶液的变化，使得在偶联条件期间扩散条件期间相对较低的Thiele模量变为相对较高的Thiele模量。 还公开了根据该方法制备的衍生多孔载体。 衍生的多孔载体具有增强的功能效率。 还公开了由吖内酮官能多孔载体制备的衍生多孔载体。

    Polymeric supports
    19.
    发明授权
    Polymeric supports 失效
    聚合物载体

    公开(公告)号：US5336742A

    公开(公告)日：1994-08-09

    申请号：US891781

    申请日：1992-06-01

    申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman

    发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman

    IPC分类号： A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/48 ,  C08F20/58 ,  C12N11/08 ,  C08F226/06 ,  C08F220/58

    CPC分类号： C12N11/08 ,  A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00 ,  C08F8/48

    摘要： Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional supports have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1,the azlactone functional supports having 0.1 to 99 molar parts of crosslinking monomer incorporated therein.

    摘要翻译： 吖内酯官能聚合物载体是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及酶或其它生物活性载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯官能载体具有下式的单元：其中R 1为H或CH 3，R 2和R 3可独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基，芳基 具有5至12个环原子，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成含有4至 12个环原子，n为0或1的整数，所述吖内酯官能载体中含有0.1至99摩尔份的交联单体。

    Variably crosslinked polymeric supports
    20.
    发明授权
    Variably crosslinked polymeric supports 失效
    可变交联的聚合物载体

    公开(公告)号：US4871824A

    公开(公告)日：1989-10-03

    申请号：US158258

    申请日：1988-02-19

    申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman

    发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman

    IPC分类号： C08F8/12 ,  A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/30 ,  C08F8/32 ,  C08F8/48 ,  C08F20/52 ,  C08F20/58 ,  C08F26/00 ,  C08F220/58 ,  C08F226/06 ,  C12N11/08

    CPC分类号： C12N11/08 ,  A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00

    摘要： Azlactone-functional polymer beads are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biomacromolecule-bearing supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional beads have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1, the azlactone functional beads having more than 5 and up to 99 molar parts of crosslinking monomer incorporated therein.

    摘要翻译： 吖内酯官能聚合物珠是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及作为酶或其他生物大分子载体的载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯功能性珠粒具有下式的单元：其中R 1是H或CH 3，R 2和R 3可以独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基，芳基 具有5至12个环原子，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成含有4至 12个环原子，并且n为整数0或1，所述吖内酯官能团珠具有多于5个且至多99摩尔份的交联单体。