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11.发明申请Morphology profiles for control of agent release rates from polymer matrices 审中-公开用于控制聚合物基质的试剂释放速率的形态概况公开(公告)号：US20080124372A1
公开(公告)日：2008-05-29
申请号：US11448956
申请日：2006-06-06
申请人： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar Kleiner , Thierry Glauser , Yiwen Tang , Wouter Roorda , Stephen Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
发明人： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar Kleiner , Thierry Glauser , Yiwen Tang , Wouter Roorda , Stephen Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
IPC分类号： A61F2/06 , B05D3/00 , A61K47/48 , A61K31/436 , A61K31/337 , A61K31/46 , A61P9/00
CPC分类号： A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
摘要翻译： 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。
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公开(公告)号：US20080057024A1
公开(公告)日：2008-03-06
申请号：US11468721
申请日：2006-08-30
申请人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
发明人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K31/785
CPC分类号： A61K47/48207 , A61K9/0019 , A61K31/436 , A61K47/595 , A61L24/001 , A61L24/046 , A61L2430/36 , C08G69/44 , Y10S977/906 , C08L77/12
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译： 一种包含适于引入血管的溶液的组合物，其包含包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并且将溶液引入血管中，所述溶液包括包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括处理剂和可调谐刺激响应性聚合物的组合的方法; 以及形成适于通过血管输送的组合颗粒。
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13.发明申请Drug-eluting implantable medical device with free radical scavenger for protecting drugs during sterilization and related method 审中-公开具有自由基清除剂的药物洗脱可植入医疗器械，用于在灭菌过程中保护药物及相关方法公开(公告)号：US20080014245A1
公开(公告)日：2008-01-17
申请号：US11487253
申请日：2006-07-14
CPC分类号： A61L27/34 , A61L31/10 , A61L2420/08 , C08L77/12
摘要： The current invention relates to devices and methods for protecting drugs coated on implantable medical devices, in particular drug-eluting stents, involving the inclusion of free or, preferably at present, polymer-bound stable nitroxides in a coating layer on the device that is either the same layer that contains the drug or that is located between the drug-containing layer and the source of free electrons used to sterilize the device.
摘要翻译： 本发明涉及用于保护涂覆在可植入医疗装置上的药物，特别是药物洗脱支架的装置和方法，其涉及在设备上的涂层中包含游离的或优选地目前为优选的聚合物结合的稳定的氮氧化物， 含有药物的相同层或位于药物含有层和用于对装置进行灭菌的自由电子源之间。
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公开(公告)号：US08936780B2
公开(公告)日：2015-01-20
申请号：US11468721
申请日：2006-08-30
申请人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
发明人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K31/785 , A61F2/00 , A61K9/00 , A61L24/00 , A61L24/04
CPC分类号： A61K47/48207 , A61K9/0019 , A61K31/436 , A61K47/595 , A61L24/001 , A61L24/046 , A61L2430/36 , C08G69/44 , Y10S977/906 , C08L77/12
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译： 一种包含适于引入血管的溶液的组合物，其包含包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并且将溶液引入血管中，所述溶液包括包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括处理剂和可调谐刺激响应性聚合物的组合的方法; 以及形成适于通过血管输送的组合颗粒。
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15.发明授权公开(公告)号：US08586069B2
公开(公告)日：2013-11-19
申请号：US11322282
申请日：2005-12-29
申请人： Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Faiyaz Ahmed Hossainy
发明人： Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Faiyaz Ahmed Hossainy
CPC分类号： A61K31/4745 , A61F2250/0067 , A61K31/436 , A61K31/573 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
摘要翻译： 提供了药物递送系统，例如具有抗增殖剂如依维莫司的药物递送支架和抗炎剂如氯倍他索。 还公开了治疗血管损伤如再狭窄或易损斑块的方法。
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16.发明授权公开(公告)号：US07749263B2
公开(公告)日：2010-07-06
申请号：US11970490
申请日：2008-01-07
申请人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。
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17.发明申请Design of poly(ester amides) for the control of agent-release from polymeric compositions 审中-公开聚（酯酰胺）的设计，用于控制聚合物组合物释放的药剂公开(公告)号：US20050288481A1
公开(公告)日：2005-12-29
申请号：US11187467
申请日：2005-07-22
申请人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner , Syed Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner , Syed Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预设以提供来自医药制品的试剂组合的预定释放速率的设计。
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18.发明申请公开(公告)号：US20050287184A1
公开(公告)日：2005-12-29
申请号：US10881540
申请日：2004-06-29
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
IPC分类号： A61K31/4745 , A61K31/56 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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19.发明申请POLY(ESTER AMIDES) FOR THE CONTROL OF AGENT-RELEASE FROM POLYMERIC COMPOSITIONS 有权POLY（ESTER AMIDES）用于控制聚合物组合物的发行公开(公告)号：US20090297583A1
公开(公告)日：2009-12-03
申请号：US12478693
申请日：2009-06-04
申请人： JESSICA R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F.A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： JESSICA R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F.A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
IPC分类号： A61K9/00 , A61K31/765 , A61P9/10
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预设以提供来自医药制品的试剂组合的预定释放速率的设计。
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20.发明申请公开(公告)号：US20080167712A1
公开(公告)日：2008-07-10
申请号：US11970490
申请日：2008-01-07
申请人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。
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