公开(公告)号：US5573929A

公开(公告)日：1996-11-12

申请号：US348972

申请日：1994-11-28

Applicant: Satoru Misawa ,  Hitoshi Matsuda ,  Yoshifumi Inoue ,  Hideyuki Furuya

Inventor： Satoru Misawa ,  Hitoshi Matsuda ,  Yoshifumi Inoue ,  Hideyuki Furuya

IPC: A61K38/00 ,  C07K14/815 ,  C12N1/21 ,  C12N9/16 ,  C12N15/10 ,  C12N15/12 ,  C12N15/15 ,  C12N15/55 ,  C12N15/62 ,  C12N15/70 ,  C12P21/06 ,  C12N1/20 ,  C12N15/63

CPC classification number: C07K14/815 ,  C12N15/10 ,  C12N9/16 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/33

Abstract: Provided is a chimeric HV1/HV3 hirudin analog useful as an anti-coagulant, exhibiting higher anti-thrombin activity and less tendency to cause bleeding than hirudin HV1. Also provided are a method of producing hirudins and hirudin analogs, as well as other proteins, employing secretion vectors, and transformed microorganisms such as E. coli. Pharmaceutical compositions comprising various hirudins or the chimeric HV1/HV3 hirudin analog of the present invention and a pharmaceutically acceptable carrier are also disclosed.

Abstract translation: 提供了一种嵌合型HV1 / HV3水蛭素类似物，可用作抗凝血剂，与水蛭素HV1相比表现出更高的抗凝血酶活性和较少的引起出血的倾向。 还提供了生产水蛭素和水蛭素类似物的方法，以及使用分泌载体和转化的微生物如大肠杆菌的其它蛋白质的方法。 还公开了包含本发明的各种水蛭素或嵌合HV1 / HV3水蛭素类似物的药物组合物和药学上可接受的载体。

公开(公告)号：US5516656A

公开(公告)日：1996-05-14

申请号：US910528

申请日：1992-07-08

Applicant: Satoru Misawa ,  Hitoshi Matsuda ,  Yoshifumi Inoue ,  Hideyuki Furuya

Inventor： Satoru Misawa ,  Hitoshi Matsuda ,  Yoshifumi Inoue ,  Hideyuki Furuya

IPC: A61K38/00 ,  C07K14/815 ,  C12N1/21 ,  C12N9/16 ,  C12N15/10 ,  C12N15/12 ,  C12N15/15 ,  C12N15/55 ,  C12N15/62 ,  C12N15/70 ,  C07K7/10 ,  A61K37/64

CPC classification number: C07K14/815 ,  C12N15/10 ,  C12N9/16 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/33

Abstract: Provided is a chimeric HV1/HV3 hirudin analog useful as an anti-coagulant, exhibiting higher anti-thrombin activity and less tendency to cause bleeding than hirudin HV1. Also provided are a method of producing hirudins and hirudin analogs, as well as other proteins, employing secretion vectors, and transformed microorganisms such as E. coli. Pharmaceutical compositions comprising various hirudins or the chimeric HV1/HV3 hirudin analog of the present invention and a pharmaceutically acceptable carrier are also disclosed.

Abstract translation: 提供了一种嵌合型HV1 / HV3水蛭素类似物，可用作抗凝血剂，与水蛭素HV1相比表现出更高的抗凝血酶活性和较少的引起出血的倾向。 还提供了生产水蛭素和水蛭素类似物的方法，以及使用分泌载体和转化的微生物如大肠杆菌的其它蛋白质的方法。 还公开了包含本发明的各种水蛭素或嵌合HV1 / HV3水蛭素类似物的药物组合物和药学上可接受的载体。

公开(公告)号：US5258530A

公开(公告)日：1993-11-02

申请号：US18188

申请日：1993-02-16

Applicant: Yoshio Katsuro ,  Hitoshi Matsuda

Inventor： Yoshio Katsuro ,  Hitoshi Matsuda

IPC: B01J27/13 ,  B01J27/25 ,  B01J31/04 ,  B01J31/22 ,  C07B61/00 ,  C07C63/331 ,  C07D307/89

CPC classification number: C07C63/331

Abstract: A process for producing a biphenyltetracarboxylic dianhydride which comprises the step of: heating phthalic anhydride at a temperature of from 135.degree. to 300.degree. C. in the presence of a palladium catalyst thereby to allow the phthalic anhydride to undergo a dimerization reaction. According to the process, biphenyltetracarboxylic dianhydride can be synthesized by the direct dimerization of phthalic anhydride.

公开(公告)号：US4161631A

公开(公告)日：1979-07-17

申请号：US924354

申请日：1978-07-13

Applicant: Hitoshi Matsuda

Inventor： Hitoshi Matsuda

IPC: H04R9/16

CPC classification number: H04R9/16

Abstract: A pickup cartridge composed of a cantilever, a plate-shaped armature and a magnet or magnetic material. The plate-shaped armature is pivotally mounted to the cantilever and stretched backward by a suspension wire through a damper disposed in front of the magnet or magnetic material. A holding means is disposed at the rear of the damper and includes a magnet with north and south poles. Coils are mounted on the armature. The magnetic flux which passes through the coils passing in the direction of the axes of the coils, but not parallel to the direction determined by a line between the north and south poles of said magnet, produces a linear push-pull output.

Abstract translation: 由悬臂，板状电枢和磁体或磁性材料组成的拾取盒。 板状电枢枢转地安装在悬臂上，并通过布置在磁体或磁性材料前面的阻尼器的悬挂线向后延伸。 保持装置设置在阻尼器的后部，并且包括具有北极和南极的磁体。 线圈安装在电枢上。 通过线圈通过的线圈的磁通量，其在线圈的轴线方向上通过但不与由所述磁体的北极和南极之间的线确定的方向平行，产生线性推挽输出。

公开(公告)号：US08980420B2

公开(公告)日：2015-03-17

申请号：US12920638

申请日：2009-03-02

Applicant: Shinji Yae ,  Tatsuya Hirano ,  Hitoshi Matsuda

Inventor： Shinji Yae ,  Tatsuya Hirano ,  Hitoshi Matsuda

IPC: B32B3/26 ,  B32B3/24 ,  G11B5/858 ,  B82Y30/00 ,  C23C18/16 ,  C23C18/18 ,  G11B5/65 ,  C23C18/54

CPC classification number: G11B5/858 ,  B82Y30/00 ,  C23C18/1619 ,  C23C18/1879 ,  C23C18/54 ,  G11B5/65 ,  Y10T428/12014 ,  Y10T428/12028 ,  Y10T428/24273 ,  Y10T428/249954 ,  Y10T428/24999

Abstract: Proposed are a composite material, wherein non-penetrating pores that are formed in a silicon surface layer are filled up with a metal or the like without leaving any voids by using the plating technique, and a method of producing the composite material. A composite material, which has been packed at a high accuracy, or in other words, in which little voids are left, can be obtained by filling up non-penetrating pores that are formed from a silicon surface (100) substantially with a second metal or an alloy of the second metal (106) with the use of the autocatalytic electroless plating technique wherein a first metal located at the bottom of the non-penetrating pores as described above serves as the starting point.

Abstract translation: 提出了一种复合材料，其中形成在硅表面层中的非穿透孔被金属等填充，而不会通过使用电镀技术而留下任何空隙，以及制造复合材料的方法。 通过填充由基本上具有第二金属的硅表面（100）形成的非穿透孔，可以获得以高精度包装的换句话说，其中留下很少空隙的复合材料 或第二金属（106）的合金与使用如上所述的非穿透孔底部的第一金属作为起始点的自催化化学镀技术。

公开(公告)号：US08722196B2

公开(公告)日：2014-05-13

申请号：US12921348

申请日：2009-03-02

Applicant: Shinji Yae ,  Tatsuya Hirano ,  Hitoshi Matsuda

Inventor： Shinji Yae ,  Tatsuya Hirano ,  Hitoshi Matsuda

IPC: B32B3/00 ,  B32B3/06 ,  B32B3/26 ,  B32B5/22 ,  B32B9/06 ,  B32B15/04

CPC classification number: H01L21/288 ,  C23C18/1619 ,  C23C18/1644 ,  C23C18/1889 ,  C23C18/31 ,  C23C18/44 ,  C23C18/54 ,  Y10T428/249953 ,  Y10T428/249955 ,  Y10T428/249977 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/249986 ,  Y10T428/249994

Abstract: Proposed are a composite material having a high adhesiveness, wherein non-penetrating pores that are formed in a silicone surface layer are filled up with a metal or the like without leaving any voids by using the plating technique and the silicone surface layer is coated with the metal or the like, and a method of producing the composite material. A composite material, which has a high adhesiveness between a second metal or an alloy of the second metal (106a, 106b) and a silicone surface, can be obtained by filling up non-penetrating pores that are formed in the surface of a silicone substrate (100) substantially with a second metal or an alloy of the second metal (106a) with the use of the autocatalytic electroless plating technique wherein a first metal located at the bottom of the non-penetrating pores as described above serves as the starting point, and coating the surface of the silicone substrate (100) with the second metal (106b).

Abstract translation: 提出具有高粘合性的复合材料，其中形成在硅氧烷表面层中的非穿透孔用金属等填充，而不会通过使用电镀技术留下任何空隙，并且硅氧烷表面层涂覆有 金属等，以及复合材料的制造方法。 通过填充在硅树脂基材的表面上形成的非穿透孔，可以获得在第二金属或第二金属（106a，106b）的合金与硅酮表面之间具有高粘附性的复合材料 （100）基本上具有第二金属或第二金属（106a）的合金，使用自催化无电镀技术，其中位于如上所述的非穿透孔底部的第一金属作为起点， 以及用所述第二金属（106b）涂覆所述硅树脂基底（100）的表面。

公开(公告)号：US4951228A

公开(公告)日：1990-08-21

申请号：US337572

申请日：1989-04-13

Applicant: Takahide Hirawa ,  Hitoshi Matsuda ,  Akira Hikita ,  Yoshikazu Kago

Inventor： Takahide Hirawa ,  Hitoshi Matsuda ,  Akira Hikita ,  Yoshikazu Kago

IPC: H04N1/387 ,  G06K15/02 ,  G06T1/00 ,  G06T11/20

CPC classification number: G06K15/02 ,  G06K2215/0045 ,  G06K2215/0051

Abstract: A priority grade is provided to each of several graphic figures. Respective contour lines of the graphic figures are classified into two groups according to respective locations. Respective contour lines in the two groups are serially selected in a descending order of main scanning coordinate values, and are compared with each other to specify a cross point having the largest coordinate value within a selected pair of cross points. A component of the raster data is generated on the basis of the selected cross point when a priority grade of the selected cross point satisfies a predetermined condition in connection with respective priority grades of the other cross points.

公开(公告)号：US4101133A

公开(公告)日：1978-07-18

申请号：US731666

申请日：1976-10-13

Applicant: Naohisa Aoki ,  Hitoshi Matsuda ,  Hideaki Hayashi

Inventor： Naohisa Aoki ,  Hitoshi Matsuda ,  Hideaki Hayashi

IPC: G11B3/14 ,  G11B3/18

CPC classification number: G11B3/14

Abstract: This invention relates to a complex resonance type pickup tone arm in which a damping member is disposed at the middle of the arm to damp low and middle frequency resonances so that the tip of the arm is prevented from being bent down.

Abstract translation: 本发明涉及一种复合共振型拾音器，其中阻尼件设置在臂的中部以阻止低频和中频谐振，从而防止臂的尖端向下弯曲。