公开(公告)号：US06284548B1

公开(公告)日：2001-09-04

申请号：US09239804

申请日：1999-01-29

申请人： Ingemar Berndtsson

发明人： Ingemar Berndtsson

IPC分类号： B01L100

CPC分类号： G01N1/38 ,  Y10T436/117497 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A method for performing a dilution step in a blood testing apparatus of a small, defined volume of a blood sample contained in a capillary tube, comprises the steps of providing an adapter for receiving the capillary tube, connecting the adapter to a conduit for diluting liquid, directing a flow of diluting liquid through the conduit and the adapter and at least partly through the capillary tube received therein, and collecting the defined volume of blood sample and the diluting liquid in a vessel. In a blood testing apparatus adapted for performing dilution of a small defined volume of a blood sample contained in a capillary tube, an adapter is inserted in a diluting liquid conduit of the apparatus. The adapter is arranged to receive the capillary tube such that flow of the diluting liquid through the conduit passes at least partly through the capillary tube.

摘要翻译： 一种用于在血液检查装置中进行稀释步骤的方法，所述血液检查装置包含在毛细管中的小的限定体积的血液样本，包括以下步骤：提供用于接收毛细管的适配器，将适配器连接到用于稀释液体的导管 引导稀释液体流通过导管和适配器并且至少部分地通过其中容纳的毛细管，并将限定体积的血液样品和稀释液体收集在容器中。 在适于对毛细管中容纳的小量血液样本进行稀释的血液检查装置中，将适配器插入设备的稀释液体导管中。 适配器布置成接收毛细管，使得稀释液体通过导管的流动至少部分地通过毛细管。

公开(公告)号：US08459130B2

公开(公告)日：2013-06-11

申请号：US13223843

申请日：2011-09-01

申请人： Ingemar Berndtsson ,  Tommy Andersson

发明人： Ingemar Berndtsson ,  Tommy Andersson

IPC分类号： G01N1/00

CPC分类号： G01N1/38 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2200/148 ,  B01L2300/021 ,  B01L2300/0867 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N35/1016 ,  G01N2035/00851

摘要： The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface. An information carrier is applied to or distributed with the device, having direct or indirect volume information about defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by using at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.

摘要翻译： 本发明提供了一种用于从较大样品体积中提取定义的样品体积的装置。 该装置包括具有参考表面的主体和从参考表面的一部分延伸到主体中的测量腔，从而形成与参考表面基本一致的至少一个开口平面。 信息载体应用于或分布在该设备上，具有关于为空腔建立的限定体积的直接或间接体积信息。 本发明还涉及一种用于将至少两个这样的装置的这种空腔的体积确定为通过使用至少两个这样的装置将至少两个液体样品稀释到分析仪器的方法， 涉及一种用于操作这种仪器的方法，包括该装置和该仪器的系统，以及一种用于操作该系统的方法。

公开(公告)号：US08247191B2

公开(公告)日：2012-08-21

申请号：US12270083

申请日：2008-11-13

申请人： Kalle Ritzen ,  Ingemar Berndtsson ,  Björn Roos ,  Gunnar Magnusson

发明人： Kalle Ritzen ,  Ingemar Berndtsson ,  Björn Roos ,  Gunnar Magnusson

IPC分类号： C12Q1/24 ,  C12M1/34 ,  C12M3/00 ,  C12M1/00 ,  C12N11/00 ,  C25B9/00 ,  C25B11/00 ,  C25B13/00 ,  G01N1/00 ,  G01N27/26 ,  G01N31/00 ,  G01N33/50 ,  G01N33/487

CPC分类号： G01N35/00029 ,  B01L3/502715 ,  B01L3/502723 ,  B01L2200/143 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2400/0481 ,  G01N2035/00148

摘要： A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the chambers being flexible; and one or more channels adapted to interconnect the pair of chambers; one of the chambers containing a predetermined amount of a reagent for blood analysis; and a sample outlet disposed next to and connected to the chamber containing the reagent, the sample outlet including an outlet cavity recessed from the upper panel, a divider disposed therein, and a cover covering the outlet cavity; the sample outlet sealing the reagent to the chamber containing the reagent. Further disclosed is the method of using the disposable cassette for measurements of hematology parameters on a blood analyzer.

摘要翻译： 用于血液分析的一次性盒包括具有上面板的壳体和具有填充入口的取样部分; 至少一对腔室，其形式为凹陷的壳体的上面板并由隔膜密封; 腔室上的隔膜的部分是柔性的; 以及适于互连所述一对腔室的一个或多个通道; 其中一个腔室含有预定量的用于血液分析的试剂; 以及旁边设置并连接到容纳所述试剂的室的样品出口，所述样品出口包括从所述上面板凹入的出口空腔，设置在其中的分隔件和覆盖所述出口腔的盖; 样品出口将试剂密封到含有试剂的室中。 还公开了使用一次性盒用于血液分析仪上血液学参数测量的方法。

公开(公告)号：US08033186B2

公开(公告)日：2011-10-11

申请号：US12444394

申请日：2007-09-24

申请人： Ingemar Berndtsson ,  Tommy Andersson

发明人： Ingemar Berndtsson ,  Tommy Andersson

IPC分类号： G01N1/00

CPC分类号： G01N1/38 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2200/148 ,  B01L2300/021 ,  B01L2300/0867 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N35/1016 ,  G01N2035/00851

摘要： The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface, the body being adapted for reception of an excess sample volume at the cavity and elimination of sample above the reference surface to leave in the cavity a measured sample volume having the defined volume. An information carrier is applied to or arranged for distribution with the device, having direct or indirect volume information about the defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by the use of at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.

摘要翻译： 本发明提供了一种用于从较大样品体积中提取定义的样品体积的装置。 该装置包括具有参考表面的主体和从参考表面的一部分延伸到主体中的测量腔，从而形成与参考表面基本一致的至少一个开口平面，该主体适于接收多余的样本体积 在空腔中并且在参考表面上方去除样品以在腔中留下具有确定体积的测量样品体积。 将信息载体应用于或布置成与装置一起分发，具有关于为空腔建立的限定体积的直接或间接体积信息。 本发明还涉及一种用于将至少两种这样的装置的这种空腔的体积确定为通过使用至少两种这样的装置将至少两种液体样品稀释到分析物的方法的方法 仪器，用于操作这种仪器的方法，涉及包括该装置和仪器的系统，以及一种用于操作该系统的方法。

公开(公告)号：US07833746B2

公开(公告)日：2010-11-16

申请号：US12118603

申请日：2008-05-09

申请人： Ingemar Berndtsson ,  Lars Svensson ,  Lennart Niklason

发明人： Ingemar Berndtsson ,  Lars Svensson ,  Lennart Niklason

IPC分类号： C12Q1/02

CPC分类号： G01N33/491 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L9/54 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0809 ,  B01L2300/0867 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/065 ,  G01N1/38 ,  G01N33/4875

摘要： A blood test instrument using a disposable cartridge and a method of measuring a blood sample using the instrument are disclosed. The instrument includes a cell counting station for counting blood cells by electrical resistance measurement, a pressure actuating component adapted to apply a pressure alternately on two flexible receptacles of a disposable cartridge removably placed in the instrument to cause flowing of a mixture of a blood sample and a liquid agent between the two receptacles to obtain proper mixing, and a conduit adapted to deliver the mixture to the cell counting station for counting. After measuring the blood sample, the instrument withdraws a washing liquid contained in another receptacle of the disposable cartridge and uses the washing liquid to clean the instrument and to deliver the mixture back to the cartridge for disposal.

摘要翻译： 公开了一种使用一次性药筒的血液检查仪器和使用该仪器测量血液样品的方法。 该仪器包括用于通过电阻测量来计数血细胞的细胞计数站，压力致动部件，其适于在可拆卸地放置在仪器中的一次性药筒的两个柔性容器上交替施加压力，以引起血液样本和 两个容器之间的液体试剂以获得适当的混合，以及适于将混合物输送到细胞计数站进行计数的导管。 在测量血液样本之后，仪器将包含在一次性药筒的另一个容器中的洗涤液体取出并使用洗涤液清洁仪器并将混合物输送到药筒以进行处理。

公开(公告)号：US20100101318A1

公开(公告)日：2010-04-29

申请号：US12444394

申请日：2007-09-24

申请人： Ingemar Berndtsson ,  Tommy Andersson

发明人： Ingemar Berndtsson ,  Tommy Andersson

IPC分类号： G01F17/00 ,  B01L3/02

CPC分类号： G01N1/38 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2200/148 ,  B01L2300/021 ,  B01L2300/0867 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N35/1016 ,  G01N2035/00851

摘要： The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface, the body being adapted for reception of an excess sample volume at the cavity and elimination of sample above the reference surface to leave in the cavity a measured sample volume having the defined volume. An information carrier is applied to or arranged for distribution with the device, having direct or indirect volume information about the defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by the use of at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.

摘要翻译： 本发明提供了一种用于从较大样品体积中提取定义的样品体积的装置。 该装置包括具有参考表面的主体和从参考表面的一部分延伸到主体中的测量腔，从而形成与参考表面基本一致的至少一个开口平面，该主体适于接收多余的样本体积 在空腔中并且在参考表面上方去除样品以在腔中留下具有确定体积的测量样品体积。 将信息载体应用于或布置成与装置一起分发，具有关于为空腔建立的限定体积的直接或间接体积信息。 本发明还涉及一种用于将至少两种这样的装置的这种空腔的体积确定为通过使用至少两种这样的装置将至少两种液体样品稀释到分析物的方法的方法 仪器，用于操作这种仪器的方法，涉及包括该装置和仪器的系统，以及一种用于操作该系统的方法。

公开(公告)号：US07608223B2

公开(公告)日：2009-10-27

申请号：US10533790

申请日：2003-11-19

申请人： Ingemar Berndtsson ,  Lars Svensson ,  Lennart Niklason

发明人： Ingemar Berndtsson ,  Lars Svensson ,  Lennart Niklason

IPC分类号： B01L3/00

CPC分类号： G01N33/491 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L9/54 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0809 ,  B01L2300/0867 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/065 ,  G01N1/38 ,  G01N33/4875

摘要： A disposable apparatus for use in blood testing includes a housing (21) having integrated means (41) for receiving a blood sample, a plurality of receptacles (28-33) for diluent and diluted sample, and a plurality of channels (34-39). Depressions are formed in a surface (27) of the housing to form the receptacles (28-33) and the channels. A diaphragm (40) seals the receptacles and the channels relative to said surface (27). When a pressure variation is applied to a portion of the diaphragm sealing a receptacle, liquid is caused to be displaced to or from that receptacle.

摘要翻译： 用于血液测试的一次性装置包括具有用于接收血液样本的集成装置（41）的壳体（21），用于稀释剂和稀释样品的多个容器（28-33）和多个通道（34-39 ）。 凹陷形成在壳体的表面（27）中以形成插座（28-33）和通道。 隔膜（40）相对于所述表面（27）密封容器和通道。 当对膜片的一部分施加压力变化来密封容器时，液体被移动到或从该容器移位。

公开(公告)号：US07335339B2

公开(公告)日：2008-02-26

申请号：US10849239

申请日：2004-05-20

申请人： Ingemar Berndtsson

发明人： Ingemar Berndtsson

IPC分类号： B01L3/00

CPC分类号： B01L3/502 ,  A61M39/223 ,  B01L2300/0645 ,  B01L2400/0478 ,  B01L2400/0644 ,  B01L2400/065 ,  G01N1/38 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A disposable apparatus for use in blood testing and being adapted for simultaneous dilution of a blood sample into two different dilution ratios, said apparatus including a block-shaped housing having integrated therein a first and a second receptacle, one of which as a first blood sample receiver being adapted to receive a blood sample; a first and a second container, each containing a defined volume of a diluent; a valve including a valve body having three valve body channels extending therethrough and being positionable in three distinct positions, one of which putting the receptacles in simultaneous communication with a respective one of the containers through pairs of the channels; and displacers for displacing diluent and diluted sample through said channels between said containers and said receptacles.

摘要翻译： 一种用于血液测试并用于将血液样品同时稀释成两种不同稀释比率的一次性装置，所述装置包括块形壳体，其中集成有第一和第二容器，其中一个作为第一血液样品 接收器适于接收血液样本; 第一和第二容器，每个容器含有限定体积的稀释剂; 阀门包括具有延伸穿过其中的三个阀体通道并且可定位在三个不同位置的阀体，其中一个通过成对的通道将容器与相应的一个容器同时连通; 以及用于将稀释剂和稀释样品置于所述容器和所述容器之间的所述通道的置换器。

公开(公告)号：US20060228263A1

公开(公告)日：2006-10-12

申请号：US11399423

申请日：2006-04-07

申请人： Ingemar Berndtsson ,  Lennart Niklason

发明人： Ingemar Berndtsson ,  Lennart Niklason

IPC分类号： B01L3/00

CPC分类号： G01N1/38 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/0475 ,  B01L2400/0478 ,  B01L2400/065 ,  B01L2400/0688 ,  Y10T436/25375 ,  Y10T436/2575

摘要： An apparatus for filling a sample volume defining device for separating at least one small defined volume of a liquid sample from a relatively larger undefined volume of said sample, said device including a first body and a second body movable relative to each other, whereby said first body has at least one cavity in a surface thereof, said at least one cavity having said defined volume. One of said first or said second body has at least one inlet opening adapted to be placed in a drop of the liquid sample. A defined channel is provided between said first and second body, which channel has fluid connection with said at least one opening and at least beyond said at least one cavity whereby the dimensions of said channel being such that said channel and said at least one cavity is filled with said liquid sample.

摘要翻译： 一种用于填充样品体积限定装置的设备，用于从相对较大的未定义体积的所述样品中分离出至少一个小的限定体积的液体样品，所述装置包括可相对于彼此移动的第一体和第二体， 主体在其表面中具有至少一个空腔，所述至少一个空腔具有所述限定的体积。 所述第一或所述第二主体中的一个具有适于放置在液体样品的液滴中的至少一个入口。 限定的通道设置在所述第一和第二主体之间，该通道与所述至少一个开口具有流体连接，并且至少超过所述至少一个空腔，由此所述通道的尺寸使得所述通道和所述至少一个空腔是 填充所述液体样品。

公开(公告)号：US08304207B2

公开(公告)日：2012-11-06

申请号：US12910097

申请日：2010-10-22

申请人： Ingemar Berndtsson ,  Lars Svensson ,  Lennart Niklason

发明人： Ingemar Berndtsson ,  Lars Svensson ,  Lennart Niklason

IPC分类号： C12Q1/02

CPC分类号： G01N33/491 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L9/54 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0809 ,  B01L2300/0867 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/065 ,  G01N1/38 ,  G01N33/4875

摘要： A blood test instrument using a disposable cartridge and a method of measuring a blood sample using the instrument are disclosed. The instrument includes a cell counting station for counting blood cells by electrical resistance measurement, a pressure actuating component adapted to apply a pressure alternately on two flexible receptacles of a disposable cartridge removably placed in the instrument to cause flowing of a mixture of a blood sample and a liquid agent between the two receptacles to obtain proper mixing, and a conduit adapted to deliver the mixture to the cell counting station for counting. After measuring the blood sample, the instrument withdraws a washing liquid contained in another receptacle of the disposable cartridge and uses the washing liquid to clean the instrument and to deliver the mixture back to the cartridge for disposal.

摘要翻译： 公开了一种使用一次性药筒的血液检查仪器和使用该仪器测量血液样品的方法。 该仪器包括用于通过电阻测量来计数血细胞的细胞计数站，压力致动部件，其适于在可拆卸地放置在仪器中的一次性药筒的两个柔性容器上交替施加压力，以引起血液样本和 两个容器之间的液体试剂以获得适当的混合，以及适于将混合物输送到细胞计数站进行计数的导管。 在测量血液样本之后，仪器将包含在一次性药筒的另一个容器中的洗涤液体取出并使用洗涤液清洁仪器并将混合物输送到药筒以进行处理。