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11.发明授权
公开(公告)号：US5736345A
公开(公告)日：1998-04-07
申请号：US455755
申请日：1995-05-31
IPC分类号： C07K14/475 , C07K14/785 , C12N5/071 , C12N15/85 , C12N15/01 , C12Q1/68 , G01N33/483
CPC分类号： C12N5/0688 , C07K14/475 , C07K14/785 , C12N15/85 , C12N2500/25 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/385 , C12N2501/39 , C12N2501/392 , C12N2501/395 , C12N2503/02
摘要： A novel bronchial or bronchiolar epithelial cell from normal neonatal mammalian lung has been isolated, established and maintained for multiple passages in the absence of serum, without undergoing crisis or senescence. By careful manipulation of the nutritional/hormonal microenvironment we have been able to select, from a heterogeneous population, a single epithelial cell type which can maintain highly differentiated features in vitro. This cell type has characteristics of bronchiolar epithelial cells. A clonal line, RL-65, has been selected and observed for more than 3 years in continuous culture. It has been characterized by ultrastructural, morphological and biochemical criteria.
摘要翻译： 已经分离出来自正常新生儿哺乳动物肺的新型支气管或细支气管上皮细胞，在没有血清的情况下建立和维持多次传代，而不经历危机或衰老。 通过仔细操纵营养/激素微环境，我们已经能够从异质群体中选择能在体外保持高度分化特征的单一上皮细胞类型。 该细胞类型具有细支气管上皮细胞的特征。 克隆系RL-65在连续培养中被选择并观察3年以上。 其特征在于超微结构，形态和生化标准。
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公开(公告)号：US5714385A
公开(公告)日：1998-02-03
申请号：US435434
申请日：1995-05-10
申请人： Jennie P. Mather , Ronghao Li , Jian Chen
发明人： Jennie P. Mather , Ronghao Li , Jian Chen
CPC分类号： C12N5/0622 , A61K35/12 , C12N2500/90 , C12N2501/195 , C12N2501/40 , C12N2501/998
摘要： A method for enhancing the survival and/or proliferation of Schwann cells (especially human Schwann cells) in cell culture is disclosed which involves culturing the cells in serum free culture medium comprising gas6 and other mitogenic agents, such as heregulin and forskolin. The culturing step is generally preceded by a pre-incubation period wherein nerve tissue comprising the Schwann cells is cultured under appropriate conditions and for a period of time such that demyelination occurs. The isolated Schwann cells can be used as cellular prostheses to treat patients with nervous system injuries. The invention also provides a cell culture medium for culturing Schwann cells.
摘要翻译： 公开了一种用于增强细胞培养物中雪旺细胞（尤其是人雪旺细胞）的存活和/或增殖的方法，其涉及在包含气体6和其它有丝分裂剂（例如鸟氨酸和毛喉素）的无血清培养基中培养细胞。 培养步骤通常在预孵育期之前，其中包含雪旺细胞的神经组织在合适的条件下培养一段时间以使脱髓鞘发生。 孤立的施旺细胞可用作细胞假体来治疗神经系统损伤的患者。 本发明还提供了用于培养雪旺氏细胞的细胞培养基。
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公开(公告)号：US08309354B2
公开(公告)日：2012-11-13
申请号：US12018126
申请日：2008-01-22
CPC分类号： C12N5/0695
摘要： This invention discloses isolated populations of human cancer stem cells. Methods for characterizing, isolating and culturing human cancer stem cells are also disclosed. Uses for human cancer stem cells are provided.
摘要翻译： 本发明公开了人类癌症干细胞的分离群体。 还公开了表征，分离和培养人类癌症干细胞的方法。 提供用于人类癌症干细胞的用途。
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公开(公告)号：US08216578B2
公开(公告)日：2012-07-10
申请号：US12497439
申请日：2009-07-02
IPC分类号： A61K39/395
CPC分类号： G01N33/57492 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K16/30 , C07K2317/73 , G01N33/574 , G01N2333/715
摘要： The invention provides characterization of the disease and cancer-associated antigen, OSM-R.beta. The invention also provides modulators of OSM-R.beta, including a family of monoclonal antibodies that bind to antigen OSM-R.beta, and methods of diagnosing and treating various human cancers and diseases associated with OSM-R.beta.
摘要翻译： 本发明提供了疾病和癌症相关抗原的表征，OSM-R.beta。 本发明还提供OSM-R.beta的调节剂，其包括与抗原OSM-R.beta结合的单克隆抗体家族，以及诊断和治疗与OSM-R.beta相关的各种人类癌症和疾病的方法。
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15.发明授权Antibodies that bind to cancer-associated antigen CD46 and methods of use thereof 有权结合癌相关抗原CD46的抗体及其使用方法公开(公告)号：US07744878B2
公开(公告)日：2010-06-29
申请号：US11524344
申请日：2006-09-19
申请人： Jennie P. Mather
发明人： Jennie P. Mather
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody (mPA7) which binds to antigen CD46 which is present on a variety of human cancers from ovary, breast, lung, prostate, colon, kidney, and pancreas. Methods of diagnosing and treating various cancers by using antibodies such as mPA7 directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与存在于来自卵巢，乳腺，肺，前列腺，结肠，肾和胰腺的各种人类癌症的抗原CD46结合的抗体（mPA7）的开发和表征的公开。 还公开了通过使用针对该抗原的抗体如mPA7诊断和治疗各种癌症的方法。
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公开(公告)号：US20100150921A1
公开(公告)日：2010-06-17
申请号：US12705577
申请日：2010-02-13
申请人： Jennie P. Mather , Deryk T. Loo
发明人： Jennie P. Mather , Deryk T. Loo
IPC分类号： A61K39/395 , A61P35/00 , A61P35/04
CPC分类号： C07K16/3038 , A61K2039/505 , C07K16/40 , G01N33/57407 , G01N33/57484 , G01N33/57492
摘要： The invention provides the identification and characterization of a disease and cancer-associated antigen, KID31. The invention also provides modulators of KID31, including a family of monoclonal antibodies that bind to antigen KID31, and methods of diagnosing and treating various human cancers and diseases with KID31.
摘要翻译： 本发明提供了疾病和癌症相关抗原KID31的鉴定和表征。 本发明还提供KID31的调节剂，包括与抗原KID31结合的单克隆抗体家族，以及用KID31诊断和治疗各种人类癌症和疾病的方法。
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公开(公告)号：US20090269340A1
公开(公告)日：2009-10-29
申请号：US12497439
申请日：2009-07-02
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： G01N33/57492 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K16/30 , C07K2317/73 , G01N33/574 , G01N2333/715
摘要： The invention provides characterization of the disease and cancer-associated antigen, OSM-R.beta. The invention also provides modulators of OSM-R.beta, including a family of monoclonal antibodies that bind to antigen OSM-R.beta, and methods of diagnosing and treating various human cancers and diseases associated with OSM-R.beta.
摘要翻译： 本发明提供了疾病和癌症相关抗原的表征，OSM-R.beta。 本发明还提供OSM-R.beta的调节剂，其包括与抗原OSM-R.beta结合的单克隆抗体家族，以及诊断和治疗与OSM-R.beta相关的各种人类癌症和疾病的方法。
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18.发明申请NOVEL RAAG10 CELL SURFACE TARGET AND A FAMILY OF ANTIBODIES RECOGNIZING THAT TARGET 有权新RAAG10细胞表面目标和抗体识别目标的家族公开(公告)号：US20090202561A1
公开(公告)日：2009-08-13
申请号：US12413483
申请日：2009-03-27
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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公开(公告)号：US07557192B2
公开(公告)日：2009-07-07
申请号：US09904786
申请日：2001-07-12
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , G01N33/68 , G01N2333/485
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US06235498B1
公开(公告)日：2001-05-22
申请号：US08845698
申请日：1997-04-25
申请人： Jennie P. Mather , Axel Ullrich
发明人： Jennie P. Mather , Axel Ullrich
IPC分类号： C12P2102
摘要： A method for culturing a recombinant host cell comprising: determining a polypeptide factor for a polypeptide factor-dependent host cell; transforming said host cell with nucleic acid encoding said polypeptide factor; transforming the host cell with nucleic acid encoding a desired protein; and, culturing the transformed host cells in a medium lacking the polypeptide factor.
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