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公开(公告)号:US06187742B1
公开(公告)日:2001-02-13
申请号:US09274575
申请日:1999-03-23
IPC分类号: A61K3700
CPC分类号: C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , A61L2430/10
摘要: Methods and compositions are provided for the treatment of defects and disease involving the functional attachment of connective tissue, such as tendon or ligament, to bone. Preferred methods comprise administering a composition containing a bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional attachment between the connective tissue and bone, such that minimal fibrous or granulation tissue is formed at the interface between the regenerated bone and connective tissue. The method and composition are useful for augmenting tissue grafts in reconstructive surgery. The method and compositions result in closer apposition of bone to the connective tissue at earlier time points and increased strength of fixation at earlier time points.
摘要翻译: 提供了方法和组合物用于治疗涉及结缔组织(例如肌腱或韧带)到骨骼的功能性附着的缺陷和疾病。 优选的方法包括施用含有骨形态发生蛋白和合适载体的组合物。 该方法导致结缔组织与骨之间功能性附着的再生,使得在再生骨与结缔组织之间的界面处形成最小的纤维或肉芽组织。 该方法和组合物可用于在重建手术中增加组织移植物。 该方法和组合物在较早的时间点导致骨骼对结缔组织的更紧密的连接,并且在较早的时间点增加了固定的强度。
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公开(公告)号:US06177406B1
公开(公告)日:2001-01-23
申请号:US08927124
申请日:1997-09-05
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
IPC分类号: A61K3818
CPC分类号: C07K14/51 , A61K38/00 , A61L24/043 , A61L27/227 , C08L89/00
摘要: Purified BMP-3 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-3蛋白质及其生产方法。 它们可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US6150328A
公开(公告)日:2000-11-21
申请号:US721847
申请日:1991-06-14
IPC分类号: A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/12 , C12N15/18 , A61K38/17 , A61K38/18
CPC分类号: A61L27/227 , A61L24/043 , C07K14/51 , A61K38/00 , Y10S514/801 , Y10S514/90 , Y10S930/12
摘要: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2和BMP-4蛋白及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5849880A
公开(公告)日:1998-12-15
申请号:US469936
申请日:1995-06-06
IPC分类号: A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/85 , C07K14/46 , A61K38/18 , C07H21/04 , C12P21/00
CPC分类号: C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , Y10S530/84
摘要: Purified bone morphogenetic protein (BMP)-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的骨形态发生蛋白(BMP)-6蛋白及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5639638A
公开(公告)日:1997-06-17
申请号:US247907
申请日:1994-05-20
申请人: John M. Wozney , Anthony J. Celeste
发明人: John M. Wozney , Anthony J. Celeste
IPC分类号: C12N15/09 , A61K38/00 , A61K38/18 , A61P7/00 , A61P13/02 , A61P15/00 , A61P15/18 , A61P19/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/495 , C07K14/51 , C07K14/575 , C12N5/0793 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12N15/16 , C12N15/85
CPC分类号: A61K38/1875 , C07K14/51 , C07K14/575 , C12N5/0619 , C07K2319/00 , C12N2501/155 , Y10S930/12
摘要: Purified Bone Morphogenetic Protein-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception, and for the induction of bone, cartilage and/or other connective tissue.
摘要翻译: 公开了纯化骨形态发生蛋白-11蛋白及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素,例如用于避孕,以及用于诱导骨,软骨和/或其它结缔组织。
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公开(公告)号:US5459047A
公开(公告)日:1995-10-17
申请号:US251069
申请日:1994-05-27
IPC分类号: A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/85 , C12P21/02 , A01N37/18 , C07H15/12 , C07K1/00 , C12N1/21 , C12N5/00 , C12N7/00 , C12N15/00
CPC分类号: C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , Y10S530/84
摘要: Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
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公开(公告)号:US5366875A
公开(公告)日:1994-11-22
申请号:US764731
申请日:1991-09-24
IPC分类号: A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/85 , C12P21/02 , C07H15/12 , C07K3/00 , C12N5/00 , C12N7/00 , C12N15/00 , C12P19/34
CPC分类号: C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00
摘要: Purified BMP-7 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-7蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US07175997B2
公开(公告)日:2007-02-13
申请号:US10188886
申请日:2002-07-05
申请人: John M. Wozney , Anthony J. Celeste
发明人: John M. Wozney , Anthony J. Celeste
CPC分类号: A61K38/1875 , C07K14/51 , C07K14/575 , C07K2319/00 , C12N5/0619 , C12N2501/155 , Y10S930/12
摘要: Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction of bone, cartilage and/or other connective tissue.
摘要翻译: 公开了纯化的BMP-11蛋白质及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素,例如用于避孕。 此外,蛋白质可用于诱导骨,软骨和/或其它结缔组织。
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公开(公告)号:US06432919B1
公开(公告)日:2002-08-13
申请号:US07655578
申请日:1991-03-04
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
IPC分类号: A61K3816
CPC分类号: C07K14/51 , A61K38/00 , A61L24/043 , A61L27/227 , C08L89/00
摘要: Purified BMP-3 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-3蛋白质及其生产方法。 它们可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US06284872B1
公开(公告)日:2001-09-04
申请号:US08808324
申请日:1997-02-28
申请人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
IPC分类号: C07K1451
CPC分类号: C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
摘要翻译: 公开了具有肌腱/类韧带组织诱导活性的蛋白质组成。 该组合物可用于治疗腱炎和腱或韧带缺陷以及相关组织修复。
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