公开(公告)号：US06207658B1

公开(公告)日：2001-03-27

申请号：US09128862

申请日：1998-08-04

Applicant: James W. Simpkins ,  Pattie S. Green ,  Kelly E. Gridley

Inventor： James W. Simpkins ,  Pattie S. Green ,  Kelly E. Gridley

IPC: A61K3156

CPC classification number: A01N1/0221 ,  A01N1/02 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61K31/565 ,  A61K31/566

Abstract: A method is provided for preserving tissues during removal, storage and implantation into a subject by enhancing cell viability in a population of graft cells during the transplantation procedure. The method includes selecting an effective dose of a polycylic phenolic compound in a physiologically acceptable formulation and exposing at least the population of graft cells to the formulation containing the compound within a time that is effectively proximate to the transplantation procedure so as to confer cytoprotection on the population of graft cells.

Abstract translation: 提供了一种方法，用于通过在移植过程期间通过增强移植细胞群体中的细胞活力来在去除，储存和植入受试者期间保持组织。 该方法包括在生理上可接受的制剂中选择有效剂量的多环酚类化合物，并且在有效接近移植程序的时间内至少将接种细胞群体暴露于含有化合物的制剂中，以便在 移植细胞群体。

公开(公告)号：US5972923A

公开(公告)日：1999-10-26

申请号：US7915

申请日：1998-01-16

Applicant: James W. Simpkins ,  Kelly E. Gridley ,  Pattie S. Green

Inventor： James W. Simpkins ,  Kelly E. Gridley ,  Pattie S. Green

IPC: A61K45/00 ,  A61K31/05 ,  A61K31/095 ,  A61K31/135 ,  A61K31/565 ,  A61K38/00 ,  A61K38/06 ,  A61P9/00 ,  A61P25/28 ,  A61P39/00 ,  A61P39/06 ,  A61P43/00 ,  C07J1/00 ,  C12N5/0793 ,  A61K31/56 ,  A61K31/355 ,  A61K33/04

CPC classification number: C12N5/0619 ,  A61K38/06 ,  A61K38/063 ,  C12N2501/392

Abstract: The present invention concerns methods and compositions for enhancing the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants.

Abstract translation: 本发明涉及通过与抗氧化剂的协同相互作用增强多环酚类化合物的细胞保护作用的方法和组合物。

公开(公告)号：USD354263S

公开(公告)日：1995-01-10

申请号：US11904

申请日：1993-08-18

Applicant: Kelly E. Clark ,  Mary Clark

Designer： Kelly E. Clark ,  Mary Clark

公开(公告)号：US3734073A

公开(公告)日：1973-05-22

申请号：US3734073D

申请日：1971-06-01

Applicant: WALTER R ,  KELLY E

Inventor： WALTER R ,  KELLY E

IPC: F01L1/02 ,  F16D1/12 ,  F01L1/34 ,  F16H35/06

CPC classification number: F16D1/12 ,  F01L1/02 ,  F01L1/022 ,  F01L1/026 ,  F01L2103/02 ,  F02B2275/08 ,  Y10T74/1956

Abstract: A timing sprocket for a camshaft is provided with a number of positioning holes equally spaced in a circle about its axis of rotation. A vernier plate connected to the camshaft is provided with alignment holes equally spaced in a corresponding circle as the circle of positioning holes but at a slightly greater or lesser angle. Alignment of a positioning hole and an alignment hole using a positioning pin permits incremental rotational adjustment of the sprocket wheel relative to the camshaft for angular increments equal to the difference between the angles of the positioning holes and the angles of the alignment holes.

公开(公告)号：US08528511B2

公开(公告)日：2013-09-10

申请号：US12394700

申请日：2009-02-27

Applicant: Charles E. Price ,  Howard E. Moore ,  Kelly E. Stephenson

Inventor： Charles E. Price ,  Howard E. Moore ,  Kelly E. Stephenson

IPC: F02N3/00 ,  F01L9/04

CPC classification number: F01L1/24 ,  F01L1/20 ,  F01L1/205 ,  F01L1/34 ,  F01L1/462 ,  F01L3/10 ,  F01L3/22 ,  F01L7/08 ,  F01L9/04 ,  F01L2001/0535 ,  F01L2001/0537 ,  F01L2101/00 ,  F01L2101/02 ,  F01L2820/01 ,  F01L2820/02 ,  F01L2820/031 ,  F02B33/22 ,  F02D17/02 ,  F02F1/42

Abstract: An apparatus includes a valve and an actuator. The valve has a portion movably disposed within a valve pocket defined by a cylinder head of an engine. The valve is configured to move relative to the cylinder head a distance between a closed position and an opened position. The portion of the valve defines a flow opening that is in fluid communication with a cylinder of an engine when the valve is in the opened position. The actuator is configured to selectively vary the distance between the closed position and the opened position.

公开(公告)号：US20130204922A1

公开(公告)日：2013-08-08

申请号：US13814903

申请日：2011-07-25

Applicant: Amr Saad El-Bakry ,  Kelly E. Becker ,  Mark L. Crawford ,  Bryce A. Holloway ,  Glenn O. Morrell ,  Pawel K. Peczak ,  Limin Song ,  Adam K. Usadi

Inventor： Amr Saad El-Bakry ,  Kelly E. Becker ,  Mark L. Crawford ,  Bryce A. Holloway ,  Glenn O. Morrell ,  Pawel K. Peczak ,  Limin Song ,  Adam K. Usadi

IPC: H04L29/08

CPC classification number: H04L67/10 ,  G06Q10/06 ,  G06Q50/10

Abstract: An embodiment provides a method for managing a hydrocarbon asset. The method includes creating an interactive community of agents, wherein each agent comprises code and functional data structures configured to direct a processor to access resource on a network. At least one of the agents is configured to be a workflow agent, wherein the work-flow agent is configured to pursue a plan to accomplish a goal. The work-flow agent is provided with sensors to determine environmental conditions. The workflow agent is provided with the ability to communicate with other intelligent agents. The workflow agent is configured to select the plan based, at least in part, on information obtained from the sensors.

Abstract translation: 一个实施例提供了一种用于管理碳氢化合物资产的方法。 该方法包括创建代理的交互式社区，其中每个代理包括被配置为引导处理器访问网络上的资源的代码和功能数据结构。 至少一个代理被配置为工作流代理，其中工作流程代理被配置为追求完成目标的计划。 工作流程设置有传感器以确定环境条件。 工作流代理被提供与其他智能代理进行通信的能力。 工作流代理被配置为至少部分地基于从传感器获得的信息来选择计划。

公开(公告)号：US20080248467A1

公开(公告)日：2008-10-09

申请号：US11697113

申请日：2007-04-05

Applicant: Andrew D. Hollenbach ,  Kelly E. Johanson

Inventor： Andrew D. Hollenbach ,  Kelly E. Johanson

IPC: C12Q1/68

CPC classification number: C12Q1/6897 ,  C12N15/1055 ,  C12N15/1086

Abstract: Disclosed are methods for identifying molecular interactions between DNA sequences and proteins in vivo. The methods of the invention employ known or suspected DNA-binding proteins and genomic DNA in a plasmid library. Interacting molecules direct the expression of a reporter gene, the expression of which is then assayed. Also disclosed are genetic constructs useful in practicing the methods of the invention.

Abstract translation: 公开了用于在体内鉴定DNA序列和蛋白质之间的分子相互作用的方法。 本发明的方法在质粒文库中使用已知或可疑的DNA结合蛋白和基因组DNA。 交互分子指导报告基因的表达，然后测定其表达。 还公开了可用于实践本发明方法的遗传构建体。

公开(公告)号：US06173289B2

公开(公告)日：2001-01-09

申请号：US08818148

申请日：1997-03-14

Applicant: Kelly E. Sonderegger ,  Matthew G. Brooks ,  Calvin Gaisford ,  Damon Janis

Inventor： Kelly E. Sonderegger ,  Matthew G. Brooks ,  Calvin Gaisford ,  Damon Janis

IPC: G06F1730

CPC classification number: G06F21/604 ,  G06F9/445 ,  G06F9/465 ,  Y10S707/99939 ,  Y10S707/99943 ,  Y10S707/99944

Abstract: A system and method of providing associations between resources and actions in a network includes the steps of providing, in a database schema an action object class defining the structure and attributes of actions available in the network. During operation, action objects are created and stored in a database. When a user enters the system, an internal list is created at that user, identifying the resources available to that user and the action objects capable of being performed on those resources. When a user selects an resource object, the action objects associated with that resource object are displayed, the user selects the action, and the action is performed at the resource. In one example the selection of an action objects cause an associated application to be launched. Each action object represents a string of executable code. The executable code may either be hardcoded in the network software, such that action objects are created at network startup, or alternatively may be linked to the network via an external code module.

Abstract translation: 在网络中提供资源和动作之间的关联的系统和方法包括以下步骤：在数据库模式中提供定义网络中可用的动作的结构和属性的动作对象类。 在操作期间，操作对象被创建并存储在数据库中。 当用户进入系统时，在该用户处创建一个内部列表，识别可用于该用户的资源以及能够对这些资源执行的操作对象。 当用户选择资源对象时，显示与该资源对象相关联的动作对象，用户选择该动作，并且在该资源处执行动作。 在一个示例中，动作对象的选择导致相关联的应用被启动。 每个动作对象表示一串可执行代码。 可执行代码可以在网络软件中被硬编码，使得在网络启动时创建动作对象，或者可以经由外部代码模块链接到网络。

公开(公告)号：US6105069A

公开(公告)日：2000-08-15

申请号：US970069

申请日：1997-11-13

Applicant: Nicholas Huston Franklin ,  Bill Guy Bodine ,  Randall R. Cook ,  Calvin R. Gaisford ,  Matthew G. Brooks ,  Carla M. Heesch ,  Kelly E. Sonderegger

Inventor： Nicholas Huston Franklin ,  Bill Guy Bodine ,  Randall R. Cook ,  Calvin R. Gaisford ,  Matthew G. Brooks ,  Carla M. Heesch ,  Kelly E. Sonderegger

IPC: G06F1/00 ,  G06F21/00 ,  G06F15/173 ,  G06F17/00

CPC classification number: G06F21/6218 ,  G06F21/10 ,  G06F21/121 ,  G06F21/53 ,  G06F2221/2135 ,  G06F2221/2141

Abstract: A directory services system includes a resource object, such as an application object for accessing a resource associated with the resource object. Attributes of the resource object contain licensing control information. The licensing attributes may be used by executables to control access by a user to properly licensed instances of a resource corresponding to the resource object. Also, a utility may be provided to manage the licensing attributes in the resource object. A licensing function may thus control a resource, via its resource object in the directory services database. Licensing maybe easily implemented by setting a new disabling attribute in the object.

Abstract translation: 目录服务系统包括资源对象，例如用于访问与资源对象相关联的资源的应用对象。 资源对象的属性包含许可控制信息。 可执行文件可以使用许可属性来控制用户对与资源对象相对应的资源的适当许可的实例的访问。 另外，可以提供一个实用程序来管理资源对象中的许可属性。 因此许可功能可以通过目录服务数据库中的资源对象来控制资源。 许可可以通过在对象中设置一个新的禁用属性来轻松实现。

公开(公告)号：US5824672A

公开(公告)日：1998-10-20

申请号：US782883

申请日：1997-01-10

Applicant: James W. Simpkins ,  Pattie S. Green ,  Kelly E. Gridley

Inventor： James W. Simpkins ,  Pattie S. Green ,  Kelly E. Gridley

IPC: A01N1/02 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61K31/565 ,  A61K31/566 ,  A61K31/56

CPC classification number: A01N1/0221 ,  A01N1/02 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61K31/565 ,  A61K31/566

Abstract: A method is provided for preserving tissues during removal storage and implantation by enhancing cell viability in a population of graft cells during the transplantation procedure The method includes selecting an effective dose of a cyclopentanophenanthrene compound having a terminal phenol A ring in a physiologically acceptable formulation and exposing at least one of: a donor at an effective dose prior to removal of the cells; the population of cells in an ex vivo storage medium;, and a recipient tissue at an effective time prior to association with the donor graft cells; so as to confer cytoprotection on the population of graft cells.

Abstract translation: 提供了一种用于在移植过程期间通过增强移植细胞群体中的细胞活力来保存去除存储和植入期间的组织的方法。该方法包括在生理上可接受的制剂中选择有效剂量的具有末端苯酚A环的环戊烷菲类化合物和暴露 至少一种：在除去细胞之前有效剂量的供体; 在离体存储介质中的细胞群;和在与供体移植细胞缔合之前的有效时间的受体组织; 以便对移植细胞群体赋予细胞保护作用。