公开(公告)号：US09277192B2

公开(公告)日：2016-03-01

申请号：US14049228

申请日：2013-10-09

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： H04N7/18 ,  G01N23/00 ,  G01N21/84

CPC分类号： H04N7/188 ,  G01N21/84 ,  G01N23/00

摘要： The present invention relates to a system of real time micro hot cell image control for radiopharmaceutical automatic synthesizing apparatus including at least one CCD camera, a plurality of radioactivity detector, a logic control device, a computer interface control device. The plurality of radioactivity detector are connected to the logic control device, and the logic control device sends a corresponding location code to the computer interface control device when the detected radioactivity value is greater than the threshold value for selecting a nearest CCD camera and sending the taken image of the location to the computer interface control device for monitoring whether the automatic production line of radiopharmaceuticals is kept in normal operation.

公开(公告)号：US08802014B2

公开(公告)日：2014-08-12

申请号：US13252195

申请日：2011-10-03

申请人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

发明人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

IPC分类号： G21G4/08 ,  G21G1/00

CPC分类号： G21G4/08 ,  A61K51/02 ,  G21G1/0005 ,  G21G2001/0021 ,  Y10S422/903

摘要： The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.

摘要翻译： 本发明涉及Ga-68放射性核素发生器的新型结构。 它允许两种洗涤溶液通过两种Ge-68吸收剂以洗出不同化学形式的Ga-68核素。 本发明包括第一种从洗瓶中取出盐酸溶液并将其通过无机树脂吸收塔以产生Ga-68氯化镓的放射性同位素溶液的方法，第二种方法将允许Ga-68的放射性同位素溶液 柠檬酸镓通过有机树脂吸收柱，然后通过硅胶柱，用盐酸溶液洗涤，得到Ga-68氯化镓的放射性同位素溶液。

公开(公告)号：US08007730B2

公开(公告)日：2011-08-30

申请号：US12478787

申请日：2009-06-05

申请人： Ming-Hsin Li ,  Hsin-EII Wang ,  Chun-Yi Wu ,  Wuu-Jyh Lin

发明人： Ming-Hsin Li ,  Hsin-EII Wang ,  Chun-Yi Wu ,  Wuu-Jyh Lin

IPC分类号： G21C1/00 ,  G05B1/00 ,  G05D16/00 ,  B01J19/00

CPC分类号： B01J19/004

摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.

摘要翻译： 用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀 系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。 该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。 操作非常简单，可以有效提高生产效率。

公开(公告)号：US20090108018A1

公开(公告)日：2009-04-30

申请号：US11868540

申请日：2007-10-08

申请人： MING-HSIN LI ,  WUU-JYH LIN ,  TAIN-SHI ZEN

发明人： MING-HSIN LI ,  WUU-JYH LIN ,  TAIN-SHI ZEN

IPC分类号： B23Q7/12

CPC分类号： A61J1/2096 ,  B65B3/003 ,  G21G1/0005

摘要： An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.

摘要翻译： 用于放射性药物的自动分配器主要用于具有能够三维来回移动的移动机构的平台，注射器保持器和瓶保持器。 注射器支架用于容纳多个注射器。 瓶架有一个反向药瓶。 移动机构具有可绕水平轴线旋转的注射器夹具和注射器驱动机构。 注射器夹具被启动以保持注射器并将其移动到注射器针头插入药瓶的位置。 注射器驱动机构和注射器夹具同时与注射器相关联用于吸药动作。

公开(公告)号：US20220089574A1

公开(公告)日：2022-03-24

申请号：US17027748

申请日：2020-09-22

申请人： MING-HSIN LI ,  SHENG-NAN LO ,  SHIH-WEI LO ,  SHIH-YING LEE ,  SU-JUNG CHEN ,  WEI-LIN LO ,  MING-WEI CHEN ,  YUAN-RUEI HUANG

发明人： MING-HSIN LI ,  SHENG-NAN LO ,  SHIH-WEI LO ,  SHIH-YING LEE ,  SU-JUNG CHEN ,  WEI-LIN LO ,  MING-WEI CHEN ,  YUAN-RUEI HUANG

IPC分类号： C07D403/12 ,  C07F5/00

摘要： The structure and preparation method of a compound D-L2(-B)-L1-A is disclosed, A is a physiologically and pharmacologically active molecule that physically binds to a specific biological molecule or receptor; L1 is a variable structure with the molecular connection activity at both ends connecting to A and L2; L2 is a variable structure, which has three-terminal molecular connection activity connecting to L1, D and B; B is a physiologically and pharmacologically active molecule that binds to albumin, changing the A molecule in the body cyclic characteristics; D is a polycarboxylic macrocyclic structure that binds to radioisotopes; D-L2(-B)-L1-A compound can be used to express chemokine receptor 4 (CXCR4) receptors on cells, tissues, and/or organs, and after binding with radionuclides, it is suitable for detection of CXCR4 protein binding in vitro, detection of CXCR4 cell binding in vitro or detection of CXCR4 expression in in vivo animal imaging.

公开(公告)号：US11202577B2

公开(公告)日：2021-12-21

申请号：US16664946

申请日：2019-10-28

申请人： Ming-Hsin Li ,  Kai-Hung Cheng ,  Shih-Wei Lo

发明人： Ming-Hsin Li ,  Kai-Hung Cheng ,  Shih-Wei Lo

IPC分类号： A61B5/0205 ,  A61B5/029 ,  A61B5/00 ,  A61B5/021 ,  A61B5/024 ,  A61B5/369

摘要： A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

公开(公告)号：US20190076552A1

公开(公告)日：2019-03-14

申请号：US15698672

申请日：2017-09-08

申请人： Ming-Hsin Li ,  Chyng-Yann Shiue ,  Han-Chih Chang ,  Chun-Fang Feng

发明人： Ming-Hsin Li ,  Chyng-Yann Shiue ,  Han-Chih Chang ,  Chun-Fang Feng

IPC分类号： A61K49/00 ,  G06T7/00 ,  G01T1/29 ,  A61K51/00 ,  G06T7/40

摘要： Method provided for labeling a nuclear medicine for imaging tracing, comprising a labeling precursor of the HDAC inhibitor BNL-26 (C22H23N3O) and the derivatives that are separated into two classes. The first class comprises a BNL-26 (C22H23N3O) and derivatives BNL-26a (C21H21N3O), BNL-26b (C22H22N2O), and other compounds of the labeling precursors which are categorized into two parts, the first part includes BNL-26-CH2CH2OTs (C31H33N3O4S), BNL-26a-CH2CH2OTs (C30H31N3O4S), and BNL-26b-CH2CH2OTs (C31H32N2O4S), which provides labeling precursor through —CH2CH2OTs structure, and the second part includes pre-BNL-26 (C28H34N3O3B), pre-BNL-26a (C27H32N3O3B), pre-BNL-26b (C28H33N2O3B), which provides labeling precursor through 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl structure. The second class includes BNL-26 (C22H23N3O) indole/indoline, which provides a series of derivative labeling precursors derived from a secondary amide bond.

公开(公告)号：US10005727B2

公开(公告)日：2018-06-26

申请号：US15286596

申请日：2016-10-06

申请人： Ming-Hsin Li ,  Chyng-Yann Shiue ,  Han-Chih Chang ,  Chun-Fang Feng

发明人： Ming-Hsin Li ,  Chyng-Yann Shiue ,  Han-Chih Chang ,  Chun-Fang Feng

IPC分类号： C07D209/04 ,  C07D401/12 ,  C07D401/14

CPC分类号： C07D209/04 ,  C07D209/08 ,  C07D401/12 ,  C07D401/14

摘要： The present invention relates to a group of compounds for nuclear medicine imaging through F-18 labeled histone acetylation inhibitors (HDACi) of indole or indoline benzoyl amine and its derivatives, and provides a series of nuclear medicine imaging agents that bind with HDAC overexpression in vivo for diagnosis of malignant tumors discovered in the nuclear medicine imaging tracing.

公开(公告)号：US20170110211A1

公开(公告)日：2017-04-20

申请号：US14882456

申请日：2015-10-14

申请人： Ming-Hsin LI ,  Ting-Shien DUH ,  Wuu-Jyh LIN ,  Han-Hsiang CHU

发明人： Ming-Hsin LI ,  Ting-Shien DUH ,  Wuu-Jyh LIN ,  Han-Hsiang CHU

IPC分类号： G21G1/00 ,  G21G1/10

CPC分类号： G21G1/001 ,  G21G1/10 ,  G21G2001/0094

摘要： A method to produce a high-purity Zr-89 on a solid target through physical irradiation and measurement by selecting a target Barn value of the cross-sectional area of nuclear reaction, drawing a horizontal line to intersect at two points on the function diagram curve and drawing a vertical line downward from each of the two points intersecting at X-axis to obtain incident energy values at the two intersecting points on the X-axis, and followed by plotting an attenuation function diagram curve of penetration depth versus incident energy of Y-89(p,n)Zr-89, selecting an attenuation function diagram curve and a minimum attenuation position of the selected attenuation function diagram curve in correspondence to the incident energy in the interval of incident energy absorption range to obtain an optimal plating thickness value on the solid target.

公开(公告)号：US09266084B2

公开(公告)日：2016-02-23

申请号：US13916599

申请日：2013-06-13

申请人： Ming-Hsin Li ,  Hsin-Han Hsieh

发明人： Ming-Hsin Li ,  Hsin-Han Hsieh

IPC分类号： A61K51/00 ,  A61M36/14 ,  B01J19/00 ,  A61K51/08 ,  C07B59/00

CPC分类号： B01J19/0053 ,  A61K51/083 ,  C07B59/00

摘要： The invention provides an automatic synthesizer apparatus and method for producing radiopharmaceutical tumor imaging agent Gallium-68-DOTATATE with one button control process to effectively isolate the medication in vials from the contamination of environment and manual operations, saving the costs of investment in production with alleviation of the critical standard required for the environmental equipments to be used for production.

摘要翻译： 本发明提供一种用于制造放射性药物肿瘤成像剂Gallium-68-DOTATATE的自动合成装置和方法，其具有一个按钮控制过程，以有效地将小瓶中的药物与环境污染和手动操作隔离，从而节省了生产投资的成本，减轻了 环境设备用于生产所需的关键标准。