公开(公告)号：US20090108018A1

公开(公告)日：2009-04-30

申请号：US11868540

申请日：2007-10-08

申请人： MING-HSIN LI ,  WUU-JYH LIN ,  TAIN-SHI ZEN

发明人： MING-HSIN LI ,  WUU-JYH LIN ,  TAIN-SHI ZEN

IPC分类号： B23Q7/12

CPC分类号： A61J1/2096 ,  B65B3/003 ,  G21G1/0005

摘要： An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.

摘要翻译： 用于放射性药物的自动分配器主要用于具有能够三维来回移动的移动机构的平台，注射器保持器和瓶保持器。 注射器支架用于容纳多个注射器。 瓶架有一个反向药瓶。 移动机构具有可绕水平轴线旋转的注射器夹具和注射器驱动机构。 注射器夹具被启动以保持注射器并将其移动到注射器针头插入药瓶的位置。 注射器驱动机构和注射器夹具同时与注射器相关联用于吸药动作。

公开(公告)号：US20100310428A1

公开(公告)日：2010-12-09

申请号：US12478787

申请日：2009-06-05

申请人： MING-HSIN LI ,  HSIN-EII WANG ,  CHUN-YI WU ,  WUU-JYH LIN

发明人： MING-HSIN LI ,  HSIN-EII WANG ,  CHUN-YI WU ,  WUU-JYH LIN

IPC分类号： G05D16/00 ,  B01J19/00 ,  G05B11/00

CPC分类号： B01J19/004

摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.

摘要翻译： 用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀 系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。 该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。 操作非常简单，可以有效提高生产效率。

公开(公告)号：US20100087009A1

公开(公告)日：2010-04-08

申请号：US12246503

申请日：2008-10-07

申请人： MING-HSIN LI ,  Wuu-Jyh Lin

发明人： MING-HSIN LI ,  Wuu-Jyh Lin

IPC分类号： G01N31/22 ,  G06F19/00

CPC分类号： G21G1/0005 ,  G21G4/08

摘要： A method of automated formulation process for radiopharmaceutical injection medicine, including preparation for process control and calculation for formulation control, wherein the preparation steps for process control includes measuring radioactivity and size of radiopharmaceutical materials, determining measurement time and calibration time, measuring pH value and impurity percentage of radiopharmaceutical raw materials. By means of input of parameters measured and calculation of the volume of injection solvent and pH value, finished product of injection medicine is obtained when the pH value reaches 6.5, and the finished product is dispensed into the sterile bottles.

摘要翻译： 一种放射性药物注射用药物的自动配制方法，包括制剂控制和制剂控制计算的制备方法，其中过程控制的制备步骤包括测定放射性药物材料的放射性和尺寸，确定测量时间和校准时间，测量pH值和杂质 放射性药物原料的百分比。 通过测量参数的输入和注射溶剂体积的计算以及pH值，当pH值达到6.5时获得注射药物的成品，并将成品分配到无菌瓶中。

公开(公告)号：US20220227728A1

公开(公告)日：2022-07-21

申请号：US17152344

申请日：2021-01-19

申请人： MING-HSIN LI ,  KAI-HUNG CHENG ,  SHENG-NAN LO ,  SHIH-WEI LO ,  YUAN-RUEI HUANG ,  JENN-TZONG CHEN

发明人： MING-HSIN LI ,  KAI-HUNG CHENG ,  SHENG-NAN LO ,  SHIH-WEI LO ,  YUAN-RUEI HUANG ,  JENN-TZONG CHEN

IPC分类号： C07D401/04 ,  A61K51/04

摘要： The present invention discloses a series of nuclear medicine tracers that are combined with brain microtubule-associated protein Tau targeting compounds to produce a group of compounds of nuclear medicine that can be utilized for imaging of microtubule-associated protein Tau. When the positrons released by the decay encounter the electrons of the cells in the sample, utilizing the positron decay characteristics of fluorine-18 or iodine-124 isotope to generate mutual destruction reactions, a pair of opposite gamma rays is formed which are imaged by positron emission tomography. The compounds can be applied for the in vivo detection of microtubule-associated protein Tau deposits in the brain. The invention provides a strategy for diagnosis of Alzheimer's disease and a method to measure the efficacy of therapeutic drugs targeting microtubule-associated protein Tau.

公开(公告)号：US20210121074A1

公开(公告)日：2021-04-29

申请号：US16664946

申请日：2019-10-28

申请人： MING-HSIN LI ,  KAI-HUNG CHENG ,  SHIH-WEI LO

发明人： MING-HSIN LI ,  KAI-HUNG CHENG ,  SHIH-WEI LO

IPC分类号： A61B5/0205 ,  A61B5/029 ,  A61B5/0476 ,  A61B5/00

摘要： A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

公开(公告)号：US20220089574A1

公开(公告)日：2022-03-24

申请号：US17027748

申请日：2020-09-22

申请人： MING-HSIN LI ,  SHENG-NAN LO ,  SHIH-WEI LO ,  SHIH-YING LEE ,  SU-JUNG CHEN ,  WEI-LIN LO ,  MING-WEI CHEN ,  YUAN-RUEI HUANG

发明人： MING-HSIN LI ,  SHENG-NAN LO ,  SHIH-WEI LO ,  SHIH-YING LEE ,  SU-JUNG CHEN ,  WEI-LIN LO ,  MING-WEI CHEN ,  YUAN-RUEI HUANG

IPC分类号： C07D403/12 ,  C07F5/00

摘要： The structure and preparation method of a compound D-L2(-B)-L1-A is disclosed, A is a physiologically and pharmacologically active molecule that physically binds to a specific biological molecule or receptor; L1 is a variable structure with the molecular connection activity at both ends connecting to A and L2; L2 is a variable structure, which has three-terminal molecular connection activity connecting to L1, D and B; B is a physiologically and pharmacologically active molecule that binds to albumin, changing the A molecule in the body cyclic characteristics; D is a polycarboxylic macrocyclic structure that binds to radioisotopes; D-L2(-B)-L1-A compound can be used to express chemokine receptor 4 (CXCR4) receptors on cells, tissues, and/or organs, and after binding with radionuclides, it is suitable for detection of CXCR4 protein binding in vitro, detection of CXCR4 cell binding in vitro or detection of CXCR4 expression in in vivo animal imaging.

公开(公告)号：US20130084220A1

公开(公告)日：2013-04-04

申请号：US13252195

申请日：2011-10-03

申请人： MING-HSIN LI ,  JIN-JENN LIN ,  THER-JEN TING ,  I-LEA DAI

发明人： MING-HSIN LI ,  JIN-JENN LIN ,  THER-JEN TING ,  I-LEA DAI

IPC分类号： B01J19/00

CPC分类号： G21G4/08 ,  A61K51/02 ,  G21G1/0005 ,  G21G2001/0021 ,  Y10S422/903

摘要： The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.

摘要翻译： 本发明涉及Ga-68放射性核素发生器的新型结构。 它允许两种洗涤溶液通过两种Ge-68吸收剂以洗出不同化学形式的Ga-68核素。 本发明包括第一种从洗瓶中取出盐酸溶液并将其通过无机树脂吸收塔以产生Ga-68氯化镓的放射性同位素溶液的方法，第二种方法将允许Ga-68的放射性同位素溶液 柠檬酸镓通过有机树脂吸收柱，然后通过硅胶柱，用盐酸溶液洗涤，得到Ga-68氯化镓的放射性同位素溶液。

公开(公告)号：US20210121585A1

公开(公告)日：2021-04-29

申请号：US16663387

申请日：2019-10-25

申请人： MING-HSIN LI ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

发明人： MING-HSIN LI ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

IPC分类号： A61K51/08

摘要： The invention features a novel precursor provided for radioisotope labeling with ligands for specific binding of prostate-specific membrane antigen (PSMA) for prostate cancer diagnosis and treatment, and the pharmacophore of a PSMA inhibitor composed of three molecules of glutamic acid, urea and lysine is provided with three variable linkers based on pharmacological activity of the PSMA inhibitor for labeling with radioactive nucleus Ga-67, Ga-68, In-111, Lu-177, Cu-64, or Y-90 through a chelating agent for imaging analysis of human tumor models of prostate cancer and serving as a PSMA-targeted radioligand therapy for prostate cancer diseases.

公开(公告)号：US20180099933A1

公开(公告)日：2018-04-12

申请号：US15286596

申请日：2016-10-06

申请人： MING-HSIN LI ,  Chyng-Yann Shiue ,  Han-Chih Chang ,  Chun-Fang Feng

发明人： MING-HSIN LI ,  Chyng-Yann Shiue ,  Han-Chih Chang ,  Chun-Fang Feng

IPC分类号： C07D209/04 ,  C07D401/12 ,  C07D401/14

CPC分类号： C07D209/04 ,  C07D209/08 ,  C07D401/12 ,  C07D401/14

摘要： The present invention relates to a group of compounds for nuclear medicine imaging through F-18 labeled histone acetylation inhibitors (HDACi) of indole or indoline benzoyl amine and its derivatives, and provides a series of nuclear medicine imaging agents that bind with HDAC overexpression in vivo for diagnosis of malignant tumors discovered in the nuclear medicine imaging tracing.

公开(公告)号：US20140039237A1

公开(公告)日：2014-02-06

申请号：US13567107

申请日：2012-08-06

申请人： MING-HSIN LI

发明人： MING-HSIN LI

IPC分类号： A61M36/06

CPC分类号： A61M5/162 ,  A61M2205/192 ,  G21F5/015

摘要： A medication dispensing device includes a medication bottle, a perfusion device, a filter and a dispensing needle. The dispensing needle includes a lower end being shrill, smooth and seamless and puncturing into the plug of the medication bottle. The dispensing needle includes a passageway therein, and includes an opening and a groove on the side wall of the dispensing needle. The dispensing needle can puncture into the plug of the medication bottle without creating any scraps stuck in the opening of the passageway or dropping into the medication bottle. The groove can release the air and pressure of the medication bottle when the pressure in the medication bottle increases during the injection of the medication solution. Accordingly, the smoothness of the dispensation of the medication solution is improved, and the contamination of the medication solution can be avoided.

摘要翻译： 药物分配装置包括药瓶，灌注装置，过滤器和分配针。 分配针包括下端，其尖端是平滑无缝的，并刺入药瓶的塞子中。 分配针包括其中的通道，并且在分配针的侧壁上包括开口和凹槽。 分注针可以刺穿到药瓶的塞子中，而不产生粘附在通道的开口中或落入药瓶中的任何残留物。 当在注射药物溶液期间药物瓶中的压力增加时，凹槽可以释放药物瓶的空气和压力。 因此，能够提高药液的分配的平滑性，能够避免药液的污染。