公开(公告)号：US20050202015A1

公开(公告)日：2005-09-15

申请号：US10627631

申请日：2003-07-28

Applicant: Marc Achen ,  Steven Stacker

Inventor： Marc Achen ,  Steven Stacker

IPC: A61K38/19 ,  C07K16/22 ,  C07K16/24 ,  G01N33/574 ,  A61K39/395

CPC classification number: A61K38/1866 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/24 ,  G01N33/57484 ,  G01N2333/475 ,  G01N2333/52

Abstract: A method for treating and alleviating disease characterized by the expression of VEGF-D involving screening to find an organism with tumor cells expressing VEGF-D and administering an effective amount of a VEGF-D antagonist; a method for screening for neoplastic diseas, where detection of VEGF-D on or in a sample such as tumor cells, blood vessel endothelial cells or lymph vessel endothelial cells indicates neoplastic disease; a method for promoting and maintaining vascularization of normal tissue in an organism involving administering a vascularization promoting amount of VEGF-D or a fragment or analog thereof to the organism; a method for screening tumors for metastatic risk involving detecting expression of VEFG-D by a tumor which indicates metastatic risk; and a method of detecting micro-metastasis of neoplastic disease involving detection of VEGF-D on or in a tissue sample which indicates metastasis of a neoplastic disease.

Abstract translation: 一种治疗和减轻疾病的方法，其特征在于VEGF-D的表达，其涉及筛选以发现具有表达VEGF-D的肿瘤细胞的生物体并施用有效量的VEGF-D拮抗剂; 用于筛选肿瘤性疾病的方法，其中检测肿瘤细胞，血管内皮细胞或淋巴管内皮细胞等样品上或样品中的VEGF-D表示肿瘤性疾病; 一种用于促进和维持生物体中正常组织的血管化的方法，包括向生物体施用血管促进量的VEGF-D或其片段或类似物; 用于筛选肿瘤转移性风险的方法，涉及通过指示转移性风险的肿瘤检测VEFG-D的表达; 以及检测涉及在指示肿瘤性疾病转移的组织样品中或其中检测VEGF-D的肿瘤性疾病的微转移的方法。

公开(公告)号：US07534572B2

公开(公告)日：2009-05-19

申请号：US10627631

申请日：2003-07-28

Applicant: Marc Achen ,  Steven Stacker

Inventor： Marc Achen ,  Steven Stacker

IPC: G01N33/53 ,  G01N33/559 ,  G01N33/561 ,  G01N33/574 ,  G01N33/577 ,  C12P21/08

CPC classification number: A61K38/1866 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/24 ,  G01N33/57484 ,  G01N2333/475 ,  G01N2333/52

Abstract: A method for treating and alleviating disease characterized by the expression of VEGF-D involving screening to find an organism with tumor cells expressing VEGF-D and administering an effective amount of a VEGF-D antagonist; a method for screening for neoplastic diseas, where detection of VEGF-D on or in a sample such as tumor cells, blood vessel endothelial cells or lymph vessel endothelial cells indicates neoplastic disease; a method for promoting and maintaining vascularization of normal tissue in an organism involving administering a vascularization promoting amount of VEGF-D or a fragment or analog thereof to the organism; a method for screening tumors for metastatic risk involving detecting expression of VEFG-D by a tumor which indicates metastatic risk; and a method of detecting micro-metastasis of neoplastic disease involving detection of VEGF-D on or in a tissue sample which indicates metastasis of a neoplastic disease.

公开(公告)号：US20080058258A1

公开(公告)日：2008-03-06

申请号：US11772089

申请日：2007-06-29

Applicant: Marc Achen ,  Andrew Wilks ,  Steven Stacker ,  Kari Alitalo

Inventor： Marc Achen ,  Andrew Wilks ,  Steven Stacker ,  Kari Alitalo

IPC: A61K38/16 ,  A61P43/00 ,  C07K14/00 ,  C07K14/485 ,  C12N5/00

CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K14/52

Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.

Abstract translation: VEGF-D是生长因子PDGF家族的新成员，其中刺激内皮细胞增殖和血管生成并增加血管通透性，以及编码其的核苷酸序列，其生产方法，抗体及其它拮抗剂， 转染或转化的宿主细胞进行表达，含有它的药物组合物及其在医学和诊断应用中的用途。

公开(公告)号：US20070224194A1

公开(公告)日：2007-09-27

申请号：US11566195

申请日：2006-12-01

Applicant: Bradley McColl ,  Steven Stacker ,  Marc Achen ,  Karri Paavonen

Inventor： Bradley McColl ,  Steven Stacker ,  Marc Achen ,  Karri Paavonen

IPC: A61K31/7052 ,  A61K39/395

CPC classification number: C07K14/4703 ,  C07K5/1027 ,  C12N15/113

Abstract: Proprotein convertase inhibitor has been found to block proteolytic processing and activation of VEGF-C and VEGF-D and inhibit angiogenesis and/or lymphangiogenesis. Method and composition are disclosed for inhibiting angiogenesis and/or lymphangiogenesis, and for treating conditions associated with excessive angiogenesis, such as tumors and/or retinopathies, as well as conditions associated with lymphangiogenesis, such as the metastatic spread of malignancies, macular degeneration, inflammatory mediated diseases, rheumatoid arthritis, diabetic retinopathy and psoriasis in a patient. The inventive method and composition utilize proprotein convertase antagonist selected from the group consisting of an anti-proprotein convertase antibody, an antisense nucleic acid molecule against a polynucleotide coding for a proprotein convertase, and an siRNA for inhibiting proprotein convertase expression, as well as proprotein convertase inhibitors.

Abstract translation: 已经发现前蛋白转化酶抑制剂阻断VEGF-C和VEGF-D的蛋白水解加工和活化并抑制血管生成和/或淋巴管生成。 公开了用于抑制血管发生和/或淋巴管生成的方法和组合，以及用于治疗与过度血管发生相关的病症，例如肿瘤和/或视网膜病变，以及与淋巴管生成相关的病症，例如恶性肿瘤的转移性扩散，黄斑变性，炎性 介导的疾病，类风湿性关节炎，糖尿病性视网膜病变和银屑病。 本发明的方法和组合物使用选自抗前体蛋白转化酶抗体，针对编码前蛋白转化酶的多核苷酸的反义核酸分子和用于抑制前蛋白转化酶表达的siRNA以及前蛋白转化酶 抑制剂。

公开(公告)号：US20050256075A1

公开(公告)日：2005-11-17

申请号：US11064769

申请日：2005-02-24

Applicant: Kari Alitalo ,  Seppo Yla-Herttuala ,  Mikko Hiltunen ,  Markku Jeltsch ,  Marc Achen

Inventor： Kari Alitalo ,  Seppo Yla-Herttuala ,  Mikko Hiltunen ,  Markku Jeltsch ,  Marc Achen

IPC: A01N63/00 ,  A61K38/19 ,  A61K48/00 ,  C07H21/02 ,  C07K14/52 ,  C12N15/00 ,  C12P21/06

CPC classification number: C07K14/52 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0075 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/414 ,  C07H21/02 ,  C12N15/86 ,  C12N2710/10343

Abstract: The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and/or Vascular Endothelial Growth Factor D (VEGF-D) genes or proteins.

Abstract translation: 本发明提供使用血管内皮生长因子C（VEGF-C）和/或血管内皮生长因子D（VEGF-D）基因或蛋白质预防血管狭窄或再狭窄的材料和方法。