公开(公告)号：US20180015157A1

公开(公告)日：2018-01-18

申请号：US15668946

申请日：2017-08-04

Applicant: MERIAL INC.

Inventor： Paulraj Kirubakaran Lawrence ,  Russell F. Bey ,  Randy R. Simonson

IPC: A61K39/102 ,  A61K39/12 ,  A61K39/135 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/102 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/522 ,  A61K2039/552 ,  A61K2039/55588 ,  A61K2039/55594 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/00034 ,  C12N2770/32134

Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.

公开(公告)号：US20170296749A1

公开(公告)日：2017-10-19

申请号：US15487308

申请日：2017-04-13

Applicant: MERIAL INC.

Inventor： Ludovic Porcher

IPC: A61M5/20 ,  A61M5/19 ,  A61D1/02 ,  A61M5/315 ,  A61M5/32

CPC classification number: A61M5/2066 ,  A61D1/025 ,  A61M5/14526 ,  A61M5/19 ,  A61M5/2053 ,  A61M5/31501 ,  A61M5/31513 ,  A61M5/31578 ,  A61M5/3298 ,  A61M2250/00

Abstract: The invention relates to hand-held, powered injection devices, for administering fluids, including vaccines, to animals. The invention further relates to methods of use of the powered injection device for vaccinating avian animals. Powered injection devices according to the instant disclosure are ergonomically friendly, and offer rapid and consistent dosing, particularly for avian animals.

公开(公告)号：US20170296577A1

公开(公告)日：2017-10-19

申请号：US15487323

申请日：2017-04-13

Applicant: MERIAL INC. ,  GENZYME CORPORATION

Inventor： Guillaume Rigaut ,  Celine Loss-Dunod ,  Alexis Guy Andre Lucien Parisot ,  Pradeep K. Dahl

IPC: A61K31/787 ,  A61K39/12 ,  A61K31/444 ,  A61K39/04 ,  C12N7/00 ,  A61K39/00

Abstract: The present invention relates to non-mercurial preservatives, including antimicrobial polyamide polymers and octenidine, and to methods of use thereof to produce preservative-containing multi-dose formulations. The preservative-containing multi-dose formulations exhibit resistance to one or more contaminating microorganisms, and have advantageous properties with respect to long term stability of biological and small molecule active ingredients.

公开(公告)号：US09770449B2

公开(公告)日：2017-09-26

申请号：US14868927

申请日：2015-09-29

Applicant: MERIAL, INC.

Inventor： Joseph K. Rosentel, Jr. ,  Monica Tejwani ,  Arima Das-Nandy

IPC: A01N31/02 ,  A01N43/56 ,  A01N43/60 ,  A01N43/90 ,  A01N47/02 ,  A01N49/00 ,  A61K31/4985 ,  A61K31/231 ,  A61K31/365 ,  A61K31/415

CPC classification number: A61K31/4985 ,  A01N31/02 ,  A01N43/56 ,  A01N43/60 ,  A01N43/90 ,  A01N47/02 ,  A01N49/00 ,  A61K31/231 ,  A61K31/365 ,  A61K31/415 ,  A01N25/02 ,  A01N2300/00

Abstract: This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

公开(公告)号：US20170198263A1

公开(公告)日：2017-07-13

申请号：US15405992

申请日：2017-01-13

Applicant: MERIAL INC. ,  GENZYME CORPORATION

Inventor： Monica Dias Figueiredo ,  Sirkka RM Kyostio-Moore ,  Patricia Berthelette

IPC: C12N7/00 ,  A61K48/00 ,  A61K38/45 ,  C12N9/10 ,  C07K14/78

CPC classification number: C12N7/00 ,  A61K38/45 ,  A61K48/005 ,  C07K14/78 ,  C12N9/1051 ,  C12N15/86 ,  C12N2750/14111 ,  C12N2750/14121 ,  C12N2750/14143 ,  C12Y204/01212

Abstract: The present disclosure relates to recombinant viral vectors, to pharmaceutical compositions comprising such recombinant vectors, and to methods for prevention and treatment of osteoarthritis in mammals. In particular, this disclosure provides adeno-associated virus (AAV) vectors capable of expressing, in a host, osteoprotective/chondroprotective bioactive proteins, including hyaluronan synthase 2 (HAS2) and lubricin (PRG4). Methods of production of these AAV are provided, as are methods of treatment of osteoarthritis in mammalian joints, by the long-term gene expression of osteoprotective/chondroprotective proteins, including HAS2 and PRG4, in both synovial and chondrocyte cells.

公开(公告)号：USD789650S1

公开(公告)日：2017-06-20

申请号：US29562983

申请日：2016-04-30

Applicant: MERIAL, INC.

Designer： Eric Anthony Hansen

公开(公告)号：US20170087244A1

公开(公告)日：2017-03-30

申请号：US15265545

申请日：2016-09-14

Applicant: MERIAL, INC.

Inventor： Frederic David ,  Zahia Hannas-Djebbara ,  Herve Poulet ,  Jules Maarten Minke

IPC: A61K39/23 ,  C07K14/005 ,  C12N7/00 ,  A61K39/135

CPC classification number: A61K39/23 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14323 ,  C12N2750/14334 ,  C12N2750/14371 ,  C12N2770/32123 ,  C12N2770/32134

Abstract: The present invention encompasses canine parvovirus (CPV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing CPV virus-like particle (VLP), and a preparation method and a use thereof. The CPV VLPs provided by the invention are formed by the CPV VP2 protein. Further, the invention broadly encompasses vaccines comprising combinations of MLV and VLP, which are capable of overcoming MDA against a variety of pathogens, which infect a variety of different species.

公开(公告)号：US20160338815A1

公开(公告)日：2016-11-24

申请号：US15160614

申请日：2016-05-20

Applicant: MERIAL INC.

Inventor： Chien Dinh Nguyen

IPC: A61D1/02 ,  A61M11/02 ,  A23L33/135 ,  A01K45/00 ,  A01K39/00

CPC classification number: A61D1/025 ,  A01K39/00 ,  A01K45/002 ,  A23L33/135 ,  A61D7/00 ,  A61M11/02 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/587

Abstract: The invention relates to spray applicator devices and methods of use for vaccinating, or administering probiotics to, avian animals.

Abstract translation: 本发明涉及用于疫苗接种或向禽类动物施用益生菌的喷雾器装置和方法。

公开(公告)号：US20160333322A1

公开(公告)日：2016-11-17

申请号：US15154028

申请日：2016-05-13

Applicant: Merial Inc.

Inventor： Paulraj Lawrence ,  Frederic Dumas

IPC: C12N7/00 ,  A61K39/12

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  C12N2750/10034 ,  C12N2750/10051

Abstract: This invention relates to a method for rapid production of PCV2 such that an optimum yield of the virus can be obtained. This invention also relates to the vaccine useful against PCV2 which includes the PCV2 propagated using such a method.

Abstract translation: 本发明涉及一种快速生产PCV2的方法，从而可以获得病毒的最佳产量。 本发明还涉及可用于PCV2的疫苗，其包括使用这种方法繁殖的PCV2。

公开(公告)号：US20160297808A1

公开(公告)日：2016-10-13

申请号：US14757930

申请日：2014-06-23

Applicant: MERIAL, INC.

Inventor： Pascal Bindschädler ,  Wolfgang Von Deyn ,  Karsten Körber ,  Deborah L. Culbertson ,  Koshi Gunjima ,  Franz Josef Braun

IPC: C07D417/14 ,  A01N43/80 ,  C07D417/04

CPC classification number: C07D417/14 ,  A01N43/80 ,  C07D417/04 ,  C07D471/04

Abstract: The present invention relates to thiophene- or furan-substituted isothiazoline compounds of formula I wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

Abstract translation: 其中变量如权利要求和描述中所定义。 这些化合物可用于对抗或控制无脊椎害虫，特别是节肢动物害虫和线虫。 本发明还涉及通过使用这些化合物和植物繁殖材料以及包含所述化合物的农业和兽用组合物来控制无脊椎害虫的方法。