利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.02 秒)

    SEAMLESS ALGINATE CAPSULES
    11.
    发明申请
    SEAMLESS ALGINATE CAPSULES 有权
    无缝粘合胶囊

    公开(公告)号：US20110059165A1

    公开(公告)日：2011-03-10

    申请号：US12874567

    申请日：2010-09-02

    申请人： Olav Gaserod ,  Christian Klein Larsen ,  Peder Oscar Andersen

    发明人： Olav Gaserod ,  Christian Klein Larsen ,  Peder Oscar Andersen

    IPC分类号： A61K9/48 ,  A61K35/60 ,  A61P3/02 ,  B01J13/20

    CPC分类号： B01J13/046 ,  A23K40/30 ,  A23P10/30 ,  A61K9/4808 ,  A61K9/4816 ,  A61K9/4833 ,  A61K47/02 ,  A61K47/36 ,  B01J13/20 ,  B01J13/206

    摘要： The present invention is directed to a dried seamless capsule comprising an alginate shell membrane encapsulating fill material, wherein: (i) said alginate shell membrane comprises a polyvalent metal ion alginate having: (a) an average M content of from 50%-62% by weight based on the weight of the M and G content, and (b) a viscosity of 35 to 80 cps when measured as a monovalent metal ion alginate in a 3.5% water solution at 20° C. using a Brookfield LV viscometer at 60 rpm and spindle #1; (ii) said alginate shell membrane encapsulates an oil present in an amount of at least 50% by weight of said fill material; (iii) said dried seamless capsule has a disintegration time of less than 12 minutes in an intestinal buffer after pretreatment for 20 minutes in a solution of 0.1 M NaCl and HCl, pH of 3, at 37° C.; and (iv) said dried seamless capsule has a dry break force strength of at least 7 kg. The present invention is also directed to methods of making and using such dried seamless capsules.

    摘要翻译： 本发明涉及一种干燥无缝胶囊，其包含包封填充材料的藻酸盐壳膜，其中：（i）所述藻酸盐壳膜包含多价金属离子藻酸盐，其具有：（a）平均M含量为50％-62％ 基于M和G含量的重量，和（b）当在20℃下在3.5％水溶液中测量时，作为一价金属离子藻酸盐测定时的粘度为35至80cps，使用Brookfield LV粘度计在60℃ rpm和锭子＃1; （ii）所述藻酸盐壳膜包封以所述填充材料的至少50重量％的量存在的油; （iii）所述干燥的无缝胶囊在37℃在0.1M NaCl和HCl的pH为3的溶液中预处理20分钟后，在肠缓冲液中的崩解时间小于12分钟。 和（iv）所述干燥的无缝胶囊具有至少7kg的干燥断裂强度。 本发明还涉及制造和使用这种干燥无缝胶囊的方法。

    Polysaccharide capsules and methods of preparation
    13.
    发明申请
    Polysaccharide capsules and methods of preparation 有权
    多糖胶囊及其制备方法

    公开(公告)号：US20050106233A1

    公开(公告)日：2005-05-19

    申请号：US10509980

    申请日：2003-04-04

    申请人： Peder Andersen ,  Olav Gaserod ,  Christian Larsen

    发明人： Peder Andersen ,  Olav Gaserod ,  Christian Larsen

    IPC分类号： A61K8/11 ,  A61K8/19 ,  A61K8/30 ,  A61K8/72 ,  A61K8/73 ,  A61K9/48 ,  A61K9/66 ,  A61K47/04 ,  A61K47/14 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  B29C39/10

    CPC分类号： A61K9/4883 ,  A61K9/4816

    摘要： The present invention is directed to seamless capsules and methods for making seamless capsules having a high oil content. More specifically, the present invention is directed to seamless capsules, and methods for making seamless capsules, made from a process involving the steps of: (a) preparing an emulsion comprising oil, water, an emulsifier, and at least one of a water-soluble monovalent metal salt, polyvalent metal salt, and an acid, wherein said oil is present in an amount of at least 50% by weight of said emulsion; with the proviso that said emulsion does not contain marmelo mucilage; and (b) adding portions of said emulsion to an aqueous gelling bath comprised of at least one ionic polysaccharide, thereby encapsulating said portions of said emulsion in a polysaccharide gel membrane, and optionally (c) drying the resulting capsules by removing water. The capsule is, for example, an alignate gel. The capsules of the invention are suitable for a variety of applications, e.g. pharmaceutical, nutraceutical, veterinay, agricultural, cosmetic, or food applications.

    摘要翻译： 本发明涉及无缝胶囊和制备具有高油含量的无缝胶囊的方法。 更具体地说，本发明涉及无缝胶囊和制造无缝胶囊的方法，该方法包括以下步骤：（a）制备包含油，水，乳化剂和至少一种水溶性乳液的乳液， 可溶性一价金属盐，多价金属盐和酸，其中所述油以所述乳液的至少50重量％的量存在; 条件是所述乳液不含马尔默粘液; 和（b）将所述乳液的一部分加入到由至少一种离子多糖组成的水性凝胶浴中，从而将所述乳液的所述部分包封在多糖凝胶膜中，并任选地（c）通过除去水干燥所得胶囊。 胶囊是例如对齐凝胶。 本发明的胶囊适用于各种应用，例如， 制药，营养保健，兽医，农业，化妆品或食品应用。

    Method and apparatus for the preparation of capsules
    17.
    发明申请
    Method and apparatus for the preparation of capsules 有权
    用于制备胶囊的方法和装置

    公开(公告)号：US20070259097A1

    公开(公告)日：2007-11-08

    申请号：US11713176

    申请日：2007-03-02

    申请人： Peder Andersen ,  Robert Kopesky ,  Christian Larsen ,  Olav Gaserod ,  David Harvey

    发明人： Peder Andersen ,  Robert Kopesky ,  Christian Larsen ,  Olav Gaserod ,  David Harvey

    IPC分类号： A61J3/07

    CPC分类号： A61J3/07 ,  A23L17/35 ,  A61K9/4816 ,  B01J13/04 ,  Y10T428/2985

    摘要： An apparatus for a continuous encapsulation process is provided. The apparatus is a vibrating tubing used alone, in series, or in combination with an encapsulation apparatus, which is used alone or in series. The vibrating tubing is a flat coil, a standing spiral, or a flume. The encapsulation apparatus includes a winding having coils disposed in an aqueous gelling solution. The winding is rotatable about its longitudinal center axis. The winding has adjacently spaced coils forming a plurality of chambers. Objects to be encapsulated are added to the apparatus such that when the winding is rotated, the chambers transport a volume of objects through the length winding in the aqueous gelling solution in a predetermined time.

    摘要翻译： 提供了一种用于连续封装工艺的设备。 该装置是单独使用，串联使用或与单独使用或串联使用的封装装置组合使用的振动管。 振动管是扁平线圈，立管螺旋或水槽。 封装装置包括具有设置在水凝胶溶液中的线圈的绕组。 绕组可围绕其纵向中心轴线旋转。 绕组具有形成多个室的相邻间隔的线圈。 要包封的物体被添加到设备中，使得当绕组旋转时，室在预定时间内将一定体积的物体通过长度缠绕在水凝胶溶液中输送。

    GELLING COMPOSITIONS AND METHODS
    18.
    发明申请
    GELLING COMPOSITIONS AND METHODS 审中-公开
    凝胶组合物和方法

    公开(公告)号：US20070087038A1

    公开(公告)日：2007-04-19

    申请号：US11538678

    申请日：2006-10-04

    申请人： JOHNATHAN RICHARDSON ,  PETER DETTMAR ,  OLAV GASEROD ,  TROND HELGERUD

    发明人： JOHNATHAN RICHARDSON ,  PETER DETTMAR ,  OLAV GASEROD ,  TROND HELGERUD

    IPC分类号： A61K47/00

    CPC分类号： A61K31/715 ,  A23L33/30 ,  A61K9/0065 ,  A61K9/0095 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/205 ,  A61K47/02 ,  A61K47/36

    摘要： A method for the administration of a composition that augments the acidity of gastric fluid such that intra-gastric gelation of the polysaccharide:acid soluble multivalent cation formulation is initiated independent of endogenous acid secretion. The composition includes:(a) at least one of a polysaccharide, modified polysaccharide, or polysaccharide salt, each capable of ionotropic gelation, (b) at least one source of multivalent cations capable of solubilization at an acidic pH, and (c) at least one acid component capable of providing a controlled release of protons sufficient to solubilize the multivalent cations. The composition is capable of hydrating in aqueous media and subsequently forming a gel in a stomach when ingested, which gel resists peristaltic forces and remains in the stomach for an extended time. Also disclosed are edible compositions including this composition, as well as methods of inducing a satiety effect and providing controlled release of various components employing the composition of the invention.

    摘要翻译： 用于施用增加胃液酸度的组合物的方法，使得多糖：酸溶性多价阳离子制剂的胃内凝胶化独立于内源性酸分泌而开始。 组合物包括：（a）多糖，改性多糖或多糖盐中的至少一种，各自能够具有离子型凝胶化，（b）至少一种能够在酸性pH下溶解的多价阳离子源，和（c） 能够提供足以溶解多价阳离子的质子的受控释放的至少一种酸组分。 该组合物能够在水性介质中水合，随后在摄入时在胃中形成凝胶，该凝胶抵抗蠕动力并在胃中长时间保留。 还公开了包括该组合物的可食用组合物，以及诱导饱腹效果并使用本发明组合物提供控制释放各种组分的方法。

    Gelled composite
    20.
    发明授权
    Gelled composite 有权
    凝胶复合材料

    公开(公告)号：US09028872B2

    公开(公告)日：2015-05-12

    申请号：US11712612

    申请日：2007-03-01

    申请人： Olav Gaserod ,  Therese Andersen ,  Jan Egil Melvik ,  Michael Dornish ,  Peter J. Riley

    发明人： Olav Gaserod ,  Therese Andersen ,  Jan Egil Melvik ,  Michael Dornish ,  Peter J. Riley

    IPC分类号： A61K9/70 ,  A61L27/56 ,  A61K9/12 ,  A61K47/36 ,  A61L27/20 ,  A61L27/38 ,  A61L27/48

    CPC分类号： A61L27/56 ,  A61K9/122 ,  A61K47/36 ,  A61L27/20 ,  A61L27/38 ,  A61L27/48

    摘要： The invention relates to composites comprising a polysaccharide gelled within pores of a foam, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene. The composites of the present invention are simple to formulate using few steps and are useful for entrapping heat-sensitive components, such as cells, drugs, flavors or fragrances within the polysaccharide gel. In addition, the invention provides for a composite able to gently immobilize fragile components, such as living cells, without exposing such components to shear forces.

    摘要翻译： 本发明涉及包含在泡沫的孔内凝胶化的多糖的复合材料，制备方法及其用途，例如在生物医学应用中，例如细胞培养基和植入物，控制释放递送系统，食品应用，工业应用和个人 护理应用如化妆品和口腔卫生。 本发明的复合材料使用几个步骤简单的配制，并且可用于在多糖凝胶内捕获热敏组分如细胞，药物，香料或香料。 此外，本发明提供了一种复合材料，其能够轻柔地固定易碎组分如活细胞，而不会使这些组分暴露于剪切力。