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    Sulfated psyllium derivative for reducing the risk of chronic human diseases and method for preparing the same
    12.
    发明授权
    Sulfated psyllium derivative for reducing the risk of chronic human diseases and method for preparing the same 有权
    用于降低慢性人类疾病风险的硫酸化车前子衍生物及其制备方法

    公开(公告)号：US09206118B2

    公开(公告)日：2015-12-08

    申请号：US12847747

    申请日：2010-07-30

    Applicant: Liangli Yu ,  Wei Liu ,  Zhouhong Xie ,  Qin Wang ,  Boce Zhang

    Inventor： Liangli Yu ,  Wei Liu ,  Zhouhong Xie ,  Qin Wang ,  Boce Zhang

    IPC: A61K36/68 ,  C07C303/00 ,  C07C303/26 ,  A23L1/30 ,  C07C303/44

    CPC classification number: C07C303/26 ,  A23L33/105 ,  A23V2002/00 ,  C07C303/44 ,  A23V2250/5074

    Abstract: The invention is directed to a method for preparing sulfated psyllium derivatives for use to reduce the risk of chronic human diseases. The sulfation of psyllium was carried out with sulfur, trioxide, pyridine, dimethylformamide and chlorosulfonic acid in pyridine. Six total sulfated psyllium derivatives named SP1, SP2, SP3, SPR1, SPR2, and SPR3 were prepared and evaluated for their morphological and rheological properties, and bile acid-binding abilities. The invention offers a novel approach to obtaining sulfated psyllium derivatives for use in functional foods or supplemental and pharmaceutical products to increase health benefits.

    Abstract translation: 本发明涉及制备用于降低慢性人类疾病风险的硫酸化欧车前衍生物的方法。 在吡啶中用硫，三氧化物，吡啶，二甲基甲酰胺和氯磺酸进行欧车前的硫酸化反应。 制备了名为SP1，SP2，SP3，SPR1，SPR2和SPR3的六种总硫酸化车前子，其形态和流变学特性以及胆汁酸结合能力进行了评估。 本发明提供了一种新颖的方法来获得用于功能食品或补充和药物产品中的硫酸化欧车前衍生物以增加健康益处。

    Combination of PI3K Inhibitor and C-Met Inhibitor
    13.
    发明申请
    Combination of PI3K Inhibitor and C-Met Inhibitor 审中-公开
    PI3K抑制剂和C-Met抑制剂的组合

    公开(公告)号：US20150216870A1

    公开(公告)日：2015-08-06

    申请号：US14420792

    申请日：2013-08-14

    Applicant: Giordano Caponigro ,  Xizhong Huang ,  Joseph Lehar ,  Hui-Qin Wang

    Inventor： Giordano Caponigro ,  Xizhong Huang ,  Joseph Lehar ,  Hui-Qin Wang

    IPC: A61K31/53 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/4745

    CPC classification number: A61K31/53 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt thereof, and (b) at least one c-Met receptor tyrosine kinase inhibitor or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly a c-Met dependent proliferative disease; a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination.

    Abstract translation: 本发明涉及药物组合，其包含（a）磷脂酰肌醇3-激酶抑制剂或其药学上可接受的盐，和（b）至少一种c-Met受体酪氨酸激酶抑制剂或其药学上可接受的盐，用于同时，分开或 顺序给药用于治疗增殖性疾病，特别是c-Met依赖性增殖性疾病; 包含这种组合的药物组合物; 治疗具有增殖性疾病的受试者的方法，包括向有需要的受试者施用所述组合; 使用这种组合治疗增生性疾病; 以及包括这种组合的商业包装。

    Methods and Apparatus for Determination of Halohydrocarbons
    15.
    发明申请
    Methods and Apparatus for Determination of Halohydrocarbons 有权
    用于测定卤代烃的方法和装置

    公开(公告)号：US20130029427A1

    公开(公告)日：2013-01-31

    申请号：US13640312

    申请日：2011-04-14

    Applicant: Harmesh K. Saini ,  Michael J. West ,  Qin Wang ,  James Garvey ,  Paul Rand ,  Marc Angelo ,  David Johnston ,  Robert Ormond ,  Ye Han

    Inventor： Harmesh K. Saini ,  Michael J. West ,  Qin Wang ,  James Garvey ,  Paul Rand ,  Marc Angelo ,  David Johnston ,  Robert Ormond ,  Ye Han

    IPC: G01N21/75

    CPC classification number: G01N21/78 ,  G01N21/75 ,  G01N33/18 ,  G01N33/1826 ,  Y10T436/19 ,  Y10T436/193333

    Abstract: A real-time, on-line method and analytical system for determining halohydrocarbons in water which operate by (1) extracting on-line samples; (2) purging volatile halohydrocarbons from the water (e.g., with air or nitrogen); (3) carrying the purge gas containing the analytes of interest over a porous surface where the analytes are adsorbed; (4) recovering the analytes from the porous surface with heat (thermal desorption) or solvent (solvent elution) to drive the analytes into an organic chemical mixture; (5) generating an optical change (e.g., color change) in dependence upon a reaction involving the analytes and a pyridine derivative; and (6) measuring optical characteristics associated with the reaction to quantify the volatile halogenated hydrocarbon concentration.

    Abstract translation: 一种用于测定水中卤代烃的实时在线方法和分析系统，其操作为（1）提取在线样品; （2）从水中（例如用空气或氮气）吹扫挥发性卤代烃; （3）在分析物被吸附的多孔表面上携带含有感兴趣分析物的吹扫气体; （4）用热（热解吸）或溶剂（溶剂洗脱）从多孔表面回收分析物，以将分析物驱动到有机化学混合物中; （5）根据涉及分析物的反应和吡啶衍生物产生光学变化（例如，颜色变化）; 和（6）测量与反应相关的光学特性以量化挥发性卤代烃浓度。

    SULFATED PSYLLIUM DERIVATIVE FOR REDUCING THE RISK OF CHRONIC HUMAN DISEASES AND METHOD FOR PREPARING THE SAME
    16.
    发明申请
    SULFATED PSYLLIUM DERIVATIVE FOR REDUCING THE RISK OF CHRONIC HUMAN DISEASES AND METHOD FOR PREPARING THE SAME 有权
    用于减少慢性人类疾病风险的硫酸堇油酸衍生物及其制备方法

    公开(公告)号：US20110054207A1

    公开(公告)日：2011-03-03

    申请号：US12847747

    申请日：2010-07-30

    Applicant: LIANGLI YU ,  WEI LIU ,  ZHOUHONG XIE ,  QIN WANG ,  BOCE ZHANG

    Inventor： LIANGLI YU ,  WEI LIU ,  ZHOUHONG XIE ,  QIN WANG ,  BOCE ZHANG

    IPC: C07C303/26 ,  C07C303/44

    CPC classification number: C07C303/26 ,  A23L33/105 ,  A23V2002/00 ,  C07C303/44 ,  A23V2250/5074

    Abstract: The invention is directed to a method for preparing sulfated psyllium derivatives for use to reduce the risk of chronic human diseases. The sulfation of psyllium was carried out with sulfur, trioxide, pyridine, dimethylformamide and chlorosulfonic acid in pyridine. Six total sulfated psyllium derivatives named SP1, SP2, SP3, SPR1, SPR2, and SPR3 were prepared and evaluated for their morphological and rheological properties, and bile acid-binding abilities. The invention offers a novel approach to obtaining sulfated psyllium derivatives for use in functional foods or supplemental and pharmaceutical products to increase health benefits.

    Abstract translation: 本发明涉及制备用于降低慢性人类疾病风险的硫酸化欧车前衍生物的方法。 在吡啶中用硫，三氧化物，吡啶，二甲基甲酰胺和氯磺酸进行欧车前的硫酸化反应。 制备了名为SP1，SP2，SP3，SPR1，SPR2和SPR3的六种总硫酸化车前子，其形态和流变学特性以及胆汁酸结合能力进行了评估。 本发明提供了一种新颖的方法来获得用于功能食品或补充和药物产品中的硫酸化欧车前衍生物以增加健康益处。

    Moving head, coating apparatus
    18.
    发明授权
    Moving head, coating apparatus 失效
    摇头，涂装机

    公开(公告)号：US07169229B2

    公开(公告)日：2007-01-30

    申请号：US10364537

    申请日：2003-02-11

    Applicant: Gregory M. Gibson ,  Carl W. Newquist ,  John E. Hawes ,  Rene Soliz ,  Samer Mahmoud Kabbani ,  Scott A. Snodgrass ,  Altaf A. Poonawala ,  Darwin R. Frerking ,  Zi-Qin Wang ,  Ocie T. Snodgrass ,  Eric E. Anderson

    Inventor： Gregory M. Gibson ,  Carl W. Newquist ,  John E. Hawes ,  Rene Soliz ,  Samer Mahmoud Kabbani ,  Scott A. Snodgrass ,  Altaf A. Poonawala ,  Darwin R. Frerking ,  Zi-Qin Wang ,  Ocie T. Snodgrass ,  Eric E. Anderson

    IPC: B05C3/02

    CPC classification number: B05C13/00 ,  B05C5/0245 ,  B05C5/0254 ,  B05C11/1013 ,  B05C11/1015

    Abstract: The invention pertains to a coating apparatus and method in which most of the relative movement between a dispensing head and the substrate to be coated is provided by the coating head. The moving head configuration reduces the system footprint and diminishes leveling problems. A powered shuttle mechanism carries a dispensing head above a substrate to be coated while riding on a bearing located underneath the chuck holding the substrate thereby providing rigidity and reducing the system footprint. Chuck support is designed to accommodate anticipated vertical sag in the dispensing head by supporting the chuck at points along its periphery thereby permitting the chuck to sag in conjunction with the dispensing head. The shuttle mechanism is equipped with means for automatically adjusting the height of the dispensing head with respect to substrate to compensate for substrate placement error, substrate dimensional variation, and mechanical drift in the mechanical machine parts. Coating consistency is enhanced using such height adjustment. A part of the apparatus containing the fluid delivery equipment and in communication with the dispensing head may be placed on a cart and removably attached to the rest of the apparatus. There is a utility station comprising equipment for cleaning and priming the dispensing head which may be located on the removable cart. A pump in addition to main remote pumping means may be integrally mounted on the dispensing head to more precisely control fluid flow to the dispensing head. The chuck may be configured to be micro deformable so as to maintain the surface of a substrate upon it at a constant height. Fluid may be dispensed along openings of selected lengths along the length of the dispensing head using die lips attached to the dispensing head or by cutting a plurality of slots in a single dispensing head.

    Abstract translation: 本发明涉及一种涂布装置和方法，其中分配头与要涂覆的基底之间的大部分相对运动由涂覆头提供。 移动头配置减少了系统占用空间并减少了调平问题。 动力穿梭机构在被涂覆的基底上方运送分配头，同时骑在位于夹持基底的卡盘下方的轴承上，从而提供刚性并减少系统占地面积。 卡盘支撑件设计成通过在其周边的点处支撑卡盘来适应分配头部中的预期垂直松弛，从而允许卡盘与分配头一起下垂。 穿梭机构配备有用于自动调节分配头相对于基底的高度以补偿机械机器部件中的基板放置误差，基板尺寸变化和机械漂移的装置。 使用这种高度调节可提高涂层的一致性。 包含流体输送设备并与分配头连通的装置的一部分可以放置在推车上并且可移除地附接到装置的其余部分上。 有一个实用工作站，包括用于清洁和启动分配头的设备，该分配头可以位于可移动的推车上。 除了主远程泵送装置之外的泵可以一体地安装在分配头上，以更精确地控制流到分配头的流体。 卡盘可以被配置为可微变形的，以便将基板的表面保持在恒定的高度。 可以使用附接到分配头的模唇或通过在单个分配头中切割多个狭槽沿着分配头的长度沿着选定长度的开口分配流体。

    Puncture guider and puncture guiding system
    19.
    发明授权
    Puncture guider and puncture guiding system 有权

    公开(公告)号：US12064138B2

    公开(公告)日：2024-08-20

    申请号：US17254181

    申请日：2018-06-21

    Applicant: Qin Wang

    Inventor： Qin Wang

    IPC: A61B17/34

    CPC classification number: A61B17/3403

    Abstract: Disclosed are a puncture guider (02, 2) and a puncture guiding system, wherein a puncture channel (80) automatically adapted to the diameter of a puncture needle (03) can be realized in the puncture guider (02, 2). The puncture guider (02, 2) is used for connecting to a puncture support, and the puncture guider (02, 2) comprises a depth block (21) and a push plate (22), wherein the depth block (21) comprises: a connection structure for being connected to the puncture support, and a first guiding wall (211) and a second guiding wall (212), which are connected to each other and form an included angle; and the push plate (22) comprises: a needle groove plate (222), and an adaptive component. A first end face (2221) of the needle groove plate (222), and the first guiding wall (211) and the second guiding wall (212) enclose a puncture channel (80), and under the action of the adaptive component, a displacement can occur between the first end face (2221) of the needle groove plate (222) and the first guiding wall (211) and second guiding wall (212), so that the puncture channel (80) can change automatically according to the specification of the puncture needle (03), thereby automatically adapting to puncture needles (03) with different needle diameter specifications. The puncture guiding system comprises a puncture support and a puncture guider (02, 2).

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