公开(公告)号：US20220299415A1

公开(公告)日：2022-09-22

申请号：US17834542

申请日：2022-06-07

Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY ,  THE UNIVERSITY OF MELBOURNE

Inventor： Laura Elizabeth Downie ,  Leslie Yeo ,  Amarin George McDonnell

IPC: G01N11/02 ,  G01N33/487 ,  G01N29/14 ,  G01N29/02 ,  G01N29/24 ,  A61B5/00 ,  G01N13/02 ,  G01N29/00 ,  A61B8/00

Abstract: A method for evaluating Dry Eye Disease (“DED”) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.

公开(公告)号：US20220204538A1

公开(公告)日：2022-06-30

申请号：US17595019

申请日：2020-05-07

Applicant: Royal Melbourne Institute of Technology

Inventor： Nedaossadat MIRZADEH ,  Suresh BHARGAVA ,  Steven PRIVER ,  Srinivasa Reddy TELUKUTLA

IPC: C07F9/53 ,  A61P35/00 ,  C07F1/02

Abstract: A compound according to Formula (I), or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are each independently selected from optionally substituted C1-6-alkyl and optionally substituted aryl; R3, R4, R5, and R6 are each independently selected from the group consisting of H, halo, optionally substituted C1-6-alkyl, and optionally substituted C1-6 alkoxy; and R7 is a phosphorus containing moiety, wherein a phosphorus atom is bonded to Au.

公开(公告)号：US20210223097A1

公开(公告)日：2021-07-22

申请号：US17254670

申请日：2019-06-26

Applicant: Royal Melbourne Institute of Technology

Inventor： Taimur Ahmed ,  Sumeet Walia ,  Madhu Bhaskaran ,  Sharath Sriram

IPC: G01J1/42 ,  H01L31/0264 ,  H01L31/09 ,  H01L31/0392 ,  H01L31/18

Abstract: A sensor for discriminating between wavelength regions in an electromagnetic spectrum is disclosed. The sensor comprising a substrate, a sensing element supported on a surface of the substrate, and at least one pair of terminal electrodes disposed on the substrate surface in mutually spaced apart and opposing relation, and in electrical contact with the sensing element, wherein the sensing element is responsive to electromagnetic radiation to yield a change in photocurrent measured between the terminal electrodes as a function of an intensity of the electromagnetic radiation impinging thereon, wherein a positive dependency on the intensity corresponds to a first wavelength region and a negative dependency on the intensity corresponds to a second wavelength region.

公开(公告)号：US20210100963A1

公开(公告)日：2021-04-08

申请号：US17044454

申请日：2019-04-05

Applicant: Royal Melbourne Institute of Technology

Inventor： Amarin McDonnell ,  Amgad Rezk ,  Leslie Yeo

IPC: A61M11/00 ,  B05B17/06 ,  H01L41/187 ,  B06B1/06

Abstract: A nebuliser for nebulising liquid droplets includes a housing; at least one piezoelectric substrate accommodated within the housing and having a transducer surface upon which is located at least one electroacoustic transducer for generating acoustic wave energy within the substrate, and an opposing non-transducer surface; and a liquid supply system for supplying a liquid to at least one of the transducer and non-transducer surfaces. The liquid supply system includes a reservoir for accommodating the liquid, and at least one relatively rigid supply conduit in contact with the substrate for supplying the liquid from the reservoir to the substrate.

公开(公告)号：US20200216494A1

公开(公告)日：2020-07-09

申请号：US16624367

申请日：2018-06-29

Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF SOUTH AUSTRALIA ,  THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND ,  MONASH UNIVERSITY

Inventor： Stavros SELEMIDIS ,  Doug A. BROOKS ,  John O'LEARY

IPC: C07K7/06 ,  C07K14/705 ,  A61P31/00 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00

Abstract: The present invention relates generally to the field of immunomodulation. Taught herein is an agent for inhibiting immunostimulation mediated by a Toll-like receptor useful in the treatment of viral and microbial pathogenesis, diseases involving elements of autoimmunity and inflammation as well as cancer. The agent antagonizes disulfide bond formation between C98 and C475 of Toll-like receptor 7 (TLR7) thereby preventing TLR7 activation. Pharmaceutical compositions are also enabled herein.

公开(公告)号：US10404232B2

公开(公告)日：2019-09-03

申请号：US15029433

申请日：2014-09-30

Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY

Inventor： Amgad Rezk ,  Leslie Yeo ,  James Friend

IPC: H01L41/09 ,  H01L41/047 ,  H03H9/25 ,  B01L3/00 ,  B05B17/06 ,  H02N2/16

Abstract: A piezoelectric actuation platform (1) including piezoelectric substrate (3) formed from a single crystal piezoelectric material, and at least one simple electrode (5) in contact with the piezoelectric substrate for applying an electrical signal to the substrate such that a lamb or surface acoustic wave can be generated within said substrate.

公开(公告)号：US20180351095A1

公开(公告)日：2018-12-06

申请号：US15778776

申请日：2016-11-23

Applicant: Royal Melbourne Institute of Technology

Inventor： Madhu BHASKARAN ,  Sharath SRIRAM ,  Sumeet WALIA ,  Hussein Nili AHMADABADI

IPC: H01L45/00

CPC classification number: H01L45/1625 ,  H01L45/08 ,  H01L45/147

Abstract: A memristor device is disclosed comprising: a first electrode; a second electrode; a cathode metal layer disposed on a surface of the first electrode; and an active region disposed between and in electrical contact with the second electrode and the cathode metal layer, the active region comprising at least one layer of an amorphous metal oxide, wherein when a switching voltage is applied between the first and second electrodes, the active region exhibits a resistive switching behaviour. A method of fabricating a memristor device is also disclosed.

公开(公告)号：US20180141073A1

公开(公告)日：2018-05-24

申请号：US15573609

申请日：2016-05-13

Applicant: Royal Melbourne Institute of Technology

Inventor： James Tan ,  Amgad Rezk ,  Heba Ahmed ,  Leslie Yeo

IPC: B05B17/06 ,  B06B1/06 ,  B05B7/00 ,  B08B3/12

CPC classification number: B05B17/0615 ,  B05B7/0012 ,  B05B17/0661 ,  B05B17/0684 ,  B06B1/0644 ,  B08B3/12

Abstract: A device, comprising: an electroacoustic transducer on a substrate; a power supply to supply electromagnetic wave energy to the electroacoustic transducer; and a source of a substance that is movable to the substrate; wherein the electroacoustic transducer and the substrate are configured to generate acoustic wave energy that is used to move the substance from the source to the substrate, and to manipulate the substance on the substrate.

公开(公告)号：US20170284956A1

公开(公告)日：2017-10-05

申请号：US15507527

申请日：2015-09-02

Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY ,  MEAT & LIVESTOCK AUSTRALIA LIMITED

Inventor： Kourosh KALANTAR-ZADEH ,  Kyle BEREAN ,  Nam HA ,  Jian Zhen OU

IPC: G01N27/407 ,  B01D53/22

CPC classification number: G01N27/407 ,  A61B5/01 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/42 ,  A61B5/6861 ,  A61B2562/0247 ,  B01D53/22 ,  B01D53/228 ,  B01D67/0079 ,  B01D69/02 ,  B01D69/141 ,  B01D69/147 ,  B01D69/148 ,  B01D71/021 ,  B01D71/022 ,  B01D71/024 ,  B01D71/44 ,  B01D71/50 ,  B01D71/70 ,  B01D2323/21 ,  B01D2325/10 ,  B01D2325/20 ,  B01D2325/48 ,  B82Y30/00 ,  C01B32/15 ,  C01G3/02 ,  C01G45/02 ,  C01G49/02 ,  C08F38/02 ,  C08G64/00 ,  C08G77/20 ,  G01N27/40

Abstract: A gas permeable, liquid impermeable membrane for use with gas sensors consists of a film forming polymer which incorporates nanoparticles selected to improve one or more of the following: permeability to gases, to selectively regulate permeability of selected gases through the membrane, to inhibit microbial growth on the membrane. A capsule shaped container consists of wall material biocompatible with a mammal GI tract and adapted to protect the electronic and sensor devices in the capsule, which contains gas composition sensors, pressure and temperature sensors, a microcontroller, a power source and a wireless transmission device. The microprocessor receives data signals from the sensors and converts the signals into gas composition and concentration data and temperature and pressure data for transmission to an external computing device. The capsule wall incorporates gas permeable nano-composite membranes with embedded catalytic and nano void producing nanoparticles, enhancing the operation, selectivity and sensitivity of the gas sensors.

公开(公告)号：US20250053845A1

公开(公告)日：2025-02-13

申请号：US18715074

申请日：2022-11-29

Applicant: University of Virginia Patent Foundation ,  The Royal Melbourne Institute of Technology

Inventor： Miller Thomas Eaton ,  Carlos Gonzalez-Arciniegas ,  Olivier Pfister ,  Rafael Alexander ,  Nicolas Menicucci

IPC: G06N10/60 ,  G06N10/40

Abstract: Methods are disclosed for generating, manipulating, and controlling non-Gaussian quantum states in continuous variable cluster quantum states usable for quantum computing. Some methods can be used to generate, transport, and enlarge Schrödinger-Cat states embedded in the CV cluster quantum state. Some methods can be used to transform Schrödinger-Cat states embedded in the CV quantum cluster state to grid states (such as Gottesman-Kitaev-Preskill states) and enlarge the grid states. In certain embodiments, some of the methods may be used to generate and control non-Gaussian states in macronode cluster quantum states such as cluster states comprising two-mode macronodes.