公开(公告)号：US11559763B2

公开(公告)日：2023-01-24

申请号：US17185301

申请日：2021-02-25

Applicant: Research Triangle Institute

Inventor： Marty Lail ,  Luke Coleman

IPC: B01D53/14 ,  B01D53/78 ,  B01D53/62 ,  B01D53/56 ,  B01D53/48 ,  B01D53/50

Abstract: A solvent system for the removal of acid gases from mixed gas streams is provided. Also provided is a process for removing acid gases from mixed gas streams using the disclosed solvent systems. The solvent systems may be utilized within a gas processing system.

公开(公告)号：US11535630B2

公开(公告)日：2022-12-27

申请号：US17082650

申请日：2020-10-28

Applicant: Research Triangle Institute

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas ,  Kenneth S. Rehder ,  Srinivas Olepu

IPC: C07D491/107 ,  C07D403/12 ,  C07D231/14 ,  C07D403/06 ,  C07D407/12 ,  C07D413/12 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08 ,  C07D403/04 ,  C07D403/14

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20220258144A1

公开(公告)日：2022-08-18

申请号：US17471747

申请日：2021-09-10

Applicant: Research Triangle Institute

Inventor： Ignacio Luz-Minguez ,  Mustapha Soukri ,  David Dausch

IPC: B01J31/16 ,  B01J31/06 ,  B01J35/00 ,  B01J35/02 ,  B01J35/06 ,  B01J35/04 ,  B01J37/04 ,  B01J37/03 ,  A62D3/35 ,  B01D53/86

Abstract: A metal organic framework (MOF)-polymer composite for detoxifying a chemical warfare agent (CWA) comprises MOF nanoparticles having catalytically active Lewis acid sites and at least one polymer having catalytically active basic sites. The composite is configured such that the at least one polymer is in surrounding relation to the MOF nanoparticles such that at least a portion of the Lewis acid sites of the MOF nanoparticles are in proximal relation to at least a portion of the basic sites of the at least one polymer thereby forming a plurality of proximal acid-base interfaces thus enabling a bifunctional catalytic mechanism for detoxifying the CWA. The MOF-polymer composite can provide CWA detoxification without the presence of a basic compound.

公开(公告)号：US11213869B2

公开(公告)日：2022-01-04

申请号：US16267553

申请日：2019-02-05

Applicant: Research Triangle Institute

Inventor： Jeffrey Robert Piascik ,  Charles David Stokes ,  Ethan Klem ,  Brian Rhys Stoner ,  Christopher Gregory ,  Nicholas G. Baldasaro ,  Katelyn Lea Sellgren ,  David E. Rogers ,  Brian Grant ,  Brian Thomas Hawkins ,  Enzo Cellini

IPC: C02F11/13 ,  C02F11/12 ,  B09B3/00 ,  C02F9/00

Abstract: A solid waste treatment system includes: a solid-liquid separator module configured to receive mixed solid and liquid waste and separating solid material from the mixed solid and liquid waste; an accumulator and macerator module configured to receive and macerate the solid material from the solid-liquid separator module; a drying module configured to receive and dry the macerated solid material from the accumulator and macerator module; and a combustion module configured to receive and combust the dried macerated solid material from the drying module.

公开(公告)号：US20210332007A1

公开(公告)日：2021-10-28

申请号：US17369088

申请日：2021-07-07

Applicant: Research Triangle Institute

Inventor： Yanan ZHANG ,  Thuy NGUYEN ,  Nadezhda GERMAN

IPC: C07C275/38 ,  A61P25/30 ,  C07D205/04 ,  C07D207/335 ,  C07D211/38 ,  C07D213/643 ,  C07D215/12 ,  C07D239/26 ,  C07D295/135 ,  C07D333/20 ,  C07D487/08 ,  C07D491/107

Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

公开(公告)号：US20210251558A1

公开(公告)日：2021-08-19

申请号：US17236266

申请日：2021-04-21

Applicant: Research Triangle Institute

Inventor： Kristin Hedgepath Gilchrist ,  Sonia Grego ,  Gregory Frederick Lewis ,  Meghan Sarah Hegarty-Craver

IPC: A61B5/00 ,  A61B5/352 ,  A61B5/11 ,  A61B5/0205 ,  G16H50/30

Abstract: A computer implemented method is disclosed for detecting a mild traumatic brain injury (mTBI) on a subject having recently suffered a head injury. The method includes (1) receiving first electrocardiogram (ECG) data from the subject during a first transition from a first position to a second position; and (2) determining a probability value of mTBI within the subject based at least partially on the first ECG data during the first transition. The first position may be a prone position or a supine position and the second position may be a standing position.

公开(公告)号：US10948348B2

公开(公告)日：2021-03-16

申请号：US16557399

申请日：2019-08-30

Applicant: Research Triangle Institute

Inventor： Kelley Jo Rountree ,  James Lynn Davis ,  Karmann Cressman Mills ,  Georgiy Bobashev ,  Robert Furberg ,  Anthony Clint Clayton

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/46

Abstract: A mannikin-based optical analyzer for analyzing an exposure of a subject to an environmental lighting condition. The analyzer has a mannikin with an outer surface replicating a facial profile of the subject, an interior inside the outer surface, and at least one pupil for admission of light into the interior of the mannikin. The analyzer has at least one optical detector configured to acquire and wavelength analyze light directed through the at least one pupil.

公开(公告)号：US10947139B2

公开(公告)日：2021-03-16

申请号：US16267420

申请日：2019-02-05

Applicant: Research Triangle Institute

Inventor： Jeffrey Robert Piascik ,  Charles David Stokes ,  Ethan Klem ,  Brian Rhys Stoner ,  Christopher Gregory ,  Nicholas G. Baldasaro ,  Katelyn Lea Sellgren ,  David E. Rogers ,  Brian Grant ,  Brian Thomas Hawkins ,  Enzo Cellini

IPC: C02F1/32 ,  C02F3/00 ,  C02F9/00 ,  C02F1/461 ,  C02F1/467 ,  C02F1/48 ,  C02F3/28 ,  C02F1/44 ,  C02F1/00 ,  C02F103/00 ,  C02F1/04

Abstract: A liquid waste treatment system includes: a baffle tank subsystem for particle settling; a preprocess tank subsystem downstream of the baffle tank subsystem; a process tank subsystem downstream of the preprocess tank subsystem; and a storage tank subsystem downstream of the process tank subsystem for the storage of treated liquid. A Microbial Fuel Cell (MFC) processing module may be included and may be inserted into the preprocess tank subsystem or implemented in a second process tank downstream of the process tank subsystem. A faster disinfection may occur in the process tank subsystem, and a slower disinfection may occur in the second process tank according to distinct respective kill curves. An electrochemical cell may be operated in a pulse mode in liquid waste in a pulsed mode.

公开(公告)号：US20200340899A1

公开(公告)日：2020-10-29

申请号：US16861550

申请日：2020-04-29

Applicant: Research Triangle Institute

Inventor： Anthony Clint Clayton ,  Howard Jerome Walls ,  Roger H. Pope

IPC: G01N15/02 ,  G01N15/14

Abstract: An optical system for particle detection. The system includes a sample inlet housing; a sample outlet housing; a detection cavity having an axially surrounding wall and disposed between the sample inlet housing and the sample outlet housing; a light source configured to irradiate light through the detection cavity to particles of a sample fluid flowing inside the wall of the detection cavity; a light detector for detecting the light that is scattered by particles of the sample fluid in the detection cavity; an alignment rail having a base and sidewalls which a) extend from the sample inlet housing to the sample outlet housing and b) connect the sample inlet housing to the sample outlet housing; and the alignment rail comprising a channel formed by the base and the sidewalls, the channel having a channel lateral width fitting to a housing width of at least one of the sample inlet housing and the sample outlet housing, whereby the sample inlet housing, the housing, and the sample outlet housing are held in alignment together.

公开(公告)号：US20200231435A1

公开(公告)日：2020-07-23

申请号：US16652318

申请日：2018-09-24

Applicant: Research Triangle Institute

Inventor： Shaojun James Zhou ,  Raghubir P. Gupta ,  John Reeves Carpenter ,  Brian S. Turk

IPC: C01B3/56 ,  C01B3/36 ,  C01B3/48 ,  C01B3/50

Abstract: Synthesis gas containing nitrogen as the majority component is processed to increase the hydrogen to carbon dioxide ratio. Nitrogen, carbon dioxide, and other contaminants are subsequently removed by a purification unit to produce a purified hydrogen gas stream. A recycle stream within the purification unit helps achieve a hydrogen purity greater than 99.9 percent, and hydrogen recovery greater than 99 percent.