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公开(公告)号：US20240406146A1
公开(公告)日：2024-12-05
申请号：US18421536
申请日：2024-01-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Domenico de Luca
IPC: H04L9/40
Abstract: A healthcare data system. The system comprises a data protection entity configured to: sign at least a portion of a routing header of a data packet with a private key held by the data protection entity, the data packet including a payload and a routing header, the payload including healthcare data and the routing header indicating an intended consumer of the data packet; and transmit the data packet on towards the intended consumer. The healthcare data system further comprises one or more data receivers, each configured to: receive the data packet; and verify the signed routing header.
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公开(公告)号：US12140601B2
公开(公告)日：2024-11-12
申请号：US16714865
申请日：2019-12-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Juliane Drobnik , Mirko Klingauf , Regula Krieg
Abstract: A computer-implemented method of automatically managing calibration of an in-vitro diagnostic system is provided comprising determining a lot calibration time period in which a lot calibration is applicable to reagent containers of the same lot, having a predefined time length starting from the time when the lot calibration becomes available, upon making a reagent container of the lot available to the system, determining whether a lot calibration that has not exceeded the lot calibration time period is available and linking the reagent container to the available lot calibration or most recent available lot calibration if more than one lot calibration is available, wherein if a new lot calibration for the same lot becomes available the method comprises replacing the existing link to the previous lot calibration with a link to the new lot calibration.
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公开(公告)号：US20240352110A1
公开(公告)日：2024-10-24
申请号：US18745539
申请日：2024-06-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Alexander Jethwa , Tobias Oelschlaegel , Corinna Schindler , Monika Soukupova , Laura Stoeckl , Christina Zimmermann
IPC: C07K16/18 , G01N33/543 , G01N33/68
CPC classification number: C07K16/18 , G01N33/543 , G01N33/6896 , C07K2317/565 , G01N2333/4709 , G01N2470/04
Abstract: The present invention relates to a monoclonal antibody or an antigen-binding fragment thereof specifically binding to Aβ42 with advantageous features for Aβ42 detection in vitro using immunoassays. Also provided is a polynucleotide or a set of polynucleotides encoding the same and a vector comprising said polynucleotide(s). Further provided is a host cell comprising the polynucleotide(s) and a corresponding production process using this host cell. Also provided herein are uses and methods employing the monoclonal antibody or an antigen-binding fragment thereof specifically binding to Aβ42 as provided herein.
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公开(公告)号：US12123857B2
公开(公告)日：2024-10-22
申请号：US16996225
申请日：2020-08-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Marc Kaminski , Stefan Quint , Benjamin Tiemann
CPC classification number: G01N30/88 , G01N30/20 , G06F16/285 , G01N2030/027 , G01N2030/202 , G01N2030/8804
Abstract: A method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer is provided including automatically monitoring a system pressure of an injection assembly of the liquid chromatography stream to generate a time series of system pressures, classifying the time series in one of two or more predetermined classes indicating different states of the LC stream and triggering a response based on the classification result.
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公开(公告)号：US12123856B2
公开(公告)日：2024-10-22
申请号：US17659772
申请日：2022-04-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Andreas Leinenbach , Aart Pieter van Doorn
CPC classification number: G01N30/36 , G01N2030/027
Abstract: A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.
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Patent Agency Ranking
公开(公告)号：US20240337598A1
公开(公告)日：2024-10-10
申请号：US18620273
申请日：2024-03-28
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Wenzel Salzmann
IPC: G01N21/359 , G01N21/33 , G01N21/3577
CPC classification number: G01N21/359 , G01N21/33 , G01N21/3577 , G01N2201/0627 , G01N2201/0635 , G01N2201/0638
Abstract: A light source (112) for generating illumination light for illuminating at least one sample is disclosed. The light source (112) comprises
at least one array of light emitters (114), wherein each of the light emitters (114) is configured for emitting at least one light beam along a light beam path, wherein the light beam has a predefined wavelength range, and
at least one reflective optical grating (116) configured for overlaying the light beam paths, at least one transfer element (118);
wherein the transfer element (118) is arranged between the array of light emitters (114) and the optical grating (116) such that the transfer element (118) directs the emitted light beams onto the optical grating (116) and provides the light beams reflected from the optical grating (116) and impinging on the transfer element (118) into at least one measurement channel (120), wherein the measurement channel (120) is configured for receiving at least one sample.-
公开(公告)号：US12085573B2
公开(公告)日：2024-09-10
申请号：US14576944
申请日：2014-12-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Martin Hund , Maria Schoedl
CPC classification number: G01N33/689 , G16H50/30 , G16H50/70 , G01N2333/475 , G01N2333/515 , G01N2333/71 , G01N2333/912 , G01N2800/368
Abstract: The present invention concerns the field of diagnostic assays for prenatal diagnosis of preeclampsia. In particular, it relates to a method for diagnosing whether a pregnant subject is not at risk for preeclampsia within a short window of time comprising a) determining the amount of at least one angiogenesis biomarker selected from the group consisting of sFlt-1, Endoglin and PlGF in a sample of said subject, and b) comparing the amount with a reference, whereby a subject being not at risk for developing preeclampsia within a short period of time is diagnosed if the amount is identical or decreased compared to the reference in the cases of sFlt-1 and Endoglin and identical or increased in the case of PlGF, wherein said reference allows for making the diagnosis with a negative predictive value of at least about 98%. Further contemplates are devices and kits for carrying out said method.
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公开(公告)号：US20240248098A1
公开(公告)日：2024-07-25
申请号：US18558098
申请日：2022-04-29
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Felix Gruenewald , Victor Johann Raul Jeger , Martin Klammer , Philipp Schuetz , Maria von Holtey , Stephen Weber , Heike Wegmeyer , Ursula-Henrike Wienhues-Thelen
CPC classification number: G01N33/6893 , G16H50/20 , G01N2800/26 , G01N2800/50
Abstract: The present invention concerns the field of diagnostics. Specifically. it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject. said first biomarker being NGAL. determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: HBP (Heparin-binding protein). Aspartate aminotransferase. Bilirubin. Alanine aminotransferase. ESM-1 and a BNP-type peptide. comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers. and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being NGAL and a second biomarker selected from the group consisting of: HBP (Heparin-binding protein). Aspartate aminotransferase. Bilirubin. Alanine aminotransferase. ESM-1 and a BNP-type peptide. or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover. the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.
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公开(公告)号：US20240242826A1
公开(公告)日：2024-07-18
申请号：US18562880
申请日：2022-05-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Matthias Frenzel , Javier Martinez Fernandez , Ramona Seel
IPC: G16H40/40
CPC classification number: G16H40/40
Abstract: A computer-implemented method of automatic registration of a device in a laboratory system comprising:
transmitting from the to be registered device specific information to a managing unit (“unit”) via a first interface;
the unit requesting a solution specific configuration from a remote infrastructure via a second interface, receiving the solution specific configuration from the remote infrastructure via the second interface, and transmitting the solution specific configuration to the device to be registered via the first interface, the solution specific configuration being based on the device specific information and configuration information about the laboratory system; and
transmitting a request from the unit comprising updated solution specific configuration to the laboratory devices, the updated solution specific configuration comprising information about the device to be registered and changes due to addition of said device, wherein the laboratory configuration step comprising providing the updated solution specific configuration to the remote infrastructure.-
20.发明公开公开(公告)号：US20240242794A1
公开(公告)日：2024-07-18
申请号：US18560126
申请日：2022-04-28
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Josep Fernandez
CPC classification number: G16H10/40 , G01N35/00871 , G01N35/04 , G01N2035/0091
Abstract: A method for operating a laboratory automation system, comprising, a transport system, a plurality of transfer devices; a portable device; and a plurality of data communication modules. The method comprises: receiving device information for the devices in the portable device, the device information being indicative a device identification; receiving a first user input in the portable device, the user input being indicative of a selection of a first device from the plurality of devices; in response to receiving the first user input, pairing the first device with the transport system for data communication in operation of the first device for at least one of sample pre-analytics and sample analysis; and providing first pairing information in the portable device, the first paring information being indicative of the first device and the distribution system being paired successfully. Further, a laboratory automation system and a laboratory in-vitro diagnostics system are provided.
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