公开(公告)号：US12180499B2

公开(公告)日：2024-12-31

申请号：US16346163

申请日：2017-10-31

Applicant: University of Florida Research Foundation, Inc.

Inventor： Eric Tzy-Shi Wang ,  Tanvi Saxena ,  Belinda Pinto ,  John Andrew Berglund

IPC: C12N15/00 ,  A61K31/704 ,  A61K38/12 ,  A61P21/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

Abstract: Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats.

公开(公告)号：US20240408269A1

公开(公告)日：2024-12-12

申请号：US18810922

申请日：2024-08-21

Applicant: University of Florida Research Foundation, Inc.

Inventor： Michele Viola Manuel ,  Ida E. Svensson Berglund ,  Benjamin G. Keselowsky ,  Malisa Sarntinoranont ,  Harpreet Singh Brar ,  Hunter B. Henderson

IPC: A61L27/04 ,  A61K33/06 ,  A61L27/54 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14 ,  A61L31/16 ,  C22C23/00

Abstract: Embodiments of the present disclosure provide for structures including an alloy of calcium, strontium, and magnesium.

公开(公告)号：US12163117B2

公开(公告)日：2024-12-10

申请号：US17423303

申请日：2020-01-10

Applicant: University of Florida Research Foundation, Inc.

Inventor： Josephine Allen ,  Bryan D. James

IPC: C12M1/42 ,  C12M1/00 ,  C12M1/12

Abstract: Described herein are bioreactor chambers and systems thereof. In an embodiment, a single-plate symmetrical bioreactor chamber is described, comprising: a flow channel extending along a first axis, wherein the flow channel comprises an inlet and an outlet at opposing ends of 5 the flow channel; a pair of struts on opposing ends of a second axis, wherein the second axis is substantially perpendicular to the first axis, wherein each strut of the pair of struts are placed on opposing sides of the flow channel, wherein the struts are configured to be coupled to a bidirectional linear actuator and configured to provide a strain perpendicular to a fluid flow through the flow channel, wherein the strain does not laterally displace cells present in the flow channel.

公开(公告)号：US20240404933A1

公开(公告)日：2024-12-05

申请号：US18676964

申请日：2024-05-29

Applicant: University of Florida Research Foundation, Inc.

Inventor： Yong Kyu Yoon ,  Saeyeong Jeon

IPC: H01L23/498 ,  H01L21/02 ,  H01L23/66

Abstract: The present disclosure describes various embodiments of systems, apparatuses, and related methods for a coaxial through-substrate-via (cx-TSV) based on a Cu/Co metaconductor. One such apparatus comprises a substrate; and a coaxial structure having an outer conductor and a metaconductor for its inner conductor, wherein the coaxial structure extends through the substrate.

公开(公告)号：US12115537B2

公开(公告)日：2024-10-15

申请号：US16763790

申请日：2018-11-14

Applicant: University of Florida Research Foundation, Inc.

Inventor： Jon P. Dobson ,  Isaac Ernest Philip Finger-Baker

IPC: B03C1/00 ,  B03C1/01 ,  B03C1/033 ,  B03C1/28

CPC classification number: B03C1/002 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22 ,  B03C2201/26

Abstract: Embodiments of the present disclosure include separating devices and systems and methods of use. Embodiments of the present disclosure include separation devices including magnetic arrays and sheet-flow separation chambers. In an embodiment, the separating device enables the generation of multiple, and in some configurations, intersecting, high gradient magnetic field lines, resulting in strong separation forces, which permit for scale up to large areas and/or volumes (e.g., extracorporeal blood filtration system).

公开(公告)号：US12090189B2

公开(公告)日：2024-09-17

申请号：US18474456

申请日：2023-09-26

Applicant: University of Florida Research Foundation, Inc.

Inventor： Daiqing Liao ,  Iqbal Mahmud ,  Guimei Tian

IPC: A61K38/04 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K38/04 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00 ,  A61K45/06

Abstract: Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.

公开(公告)号：US20240264251A1

公开(公告)日：2024-08-08

申请号：US18567084

申请日：2022-06-17

Applicant: University of Florida Research Foundation, Inc.

Inventor： Clifford Russell Bowers ,  Maria-Jose Ferrer

IPC: G01R33/28

CPC classification number: G01R33/282

Abstract: Embodiments of the present disclosure provide for systems and methods of making, processing, and purifying hyperpolarized fluid samples and fractions thereof as well as detecting and using the hyperpolarized fluid samples. The present disclosure provides for methods and systems of making hyperpolarized fluid sample (e.g., hyperpolarized target molecules), which can be analyzed using a nuclear magnetic resonance (NMR) detection device.

公开(公告)号：US12042518B2

公开(公告)日：2024-07-23

申请号：US16470802

申请日：2017-12-18

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Graciela Liliana Lorca ,  Claudio Gonzalez

IPC: A61K35/747 ,  A23L33/135 ,  A61K9/00 ,  A61K9/50 ,  A61P1/14

CPC classification number: A61K35/747 ,  A23L33/135 ,  A61K9/0056 ,  A61K9/50 ,  A61P1/14 ,  A23V2002/00 ,  A23V2400/151

Abstract: The subject invention provides compositions for promoting good health. Specifically, the subject composition can be used for alleviating symptoms of indigestion, abdominal pain, and cephalic syndrome, including in healthy subjects. In preferred embodiments, the compositions comprise an effective amount of one or more Lactobacillus isolates. Preferably, the bacteria used as an active ingredient in the compositions of the subject invention are of the L. johnsonii N6.2 strain. The subject invention also provides methods for alleviating symptoms of indigestion, abdominal pain, and cephalic syndrome. These methods comprise the administration of a composition of the subject invention, wherein the composition preferably comprises an effective amount of one or more Lactobacillus isolates. Even more preferably, the subject method utilizes an effective amount of L. johnsonii N6.2.

公开(公告)号：US12042431B2

公开(公告)日：2024-07-23

申请号：US17050267

申请日：2019-05-02

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Mark B. Sherwood ,  Craig Allen Meyers

IPC: A61F9/007

CPC classification number: A61F9/00781 ,  A61F2220/0075

Abstract: Provided herein is a glaucoma drainage implant assembly. The assembly may include a drainage implant tube defining a lumen there through defining a fluid channel between an anterior chamber of an eye and a region outside of the sclera of the eye; a closure disposed at a position outside the anterior chamber of the eye, the closure configured to preclude fluid flow from the anterior chamber of the eye to the region outside of the sclera of the eye; and a shunt received within the drainage implant tube, between the end of the drainage implant tube in the anterior chamber of the eye and the closure, where the shunt is configured to permit fluid flow from the anterior chamber of the eye, through the drainage implant tube, and out of the drainage implant tube external to the sclera of the eye through the shunt.

公开(公告)号：US12020339B2

公开(公告)日：2024-06-25

申请号：US17559504

申请日：2021-12-22

Applicant: University of Florida Research Foundation, Inc.

Inventor： Ravi Shankar Srinivasan ,  Nawari O. Nawari

IPC: G06Q30/00 ,  G06F30/20 ,  G06Q10/0631 ,  G06Q50/16

CPC classification number: G06Q50/165 ,  G06F30/20 ,  G06Q10/06313

Abstract: The present disclosure describes system and methods for determination of building code performance. One such method comprises performing design model validation, wherein design model validation comprises entering building permit application file information and checking the building permit application file information against relevant codes and regulations, using a taxonomy or neural natural language processing techniques or artificial Intelligence; performing exchange model code checking, wherein exchange model code checking comprises using a plurality of exchange models; performing code conformance checking, wherein the code conformance checking comprises receiving a request from the exchange models and passing the building permit application file information to code checking modules configured to check building code provisions and one or more regulations per local, state, national or international requirements; performing verification reporting based on input provided from the code checking modules; and performing results reporting based on findings of the verification reporting. Other methods and systems are also provided.