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公开(公告)号：US09966458B2
公开(公告)日：2018-05-08
申请号：US15178951
申请日：2016-06-10
Applicant: Westfälische Wilhelms Universität Münster , Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
Inventor： Benjamin Göhler , Volker Hamelbeck , G. Friedrich Hanne , Helmut Zacharias , Ron Naaman , Tal Zvi Markus
CPC classification number: H01L29/66984 , B82Y10/00 , H01L51/0093 , H01L51/0595
Abstract: The present invention relates to a method and a device for providing a current of spin-polarized electrons. More particularly, the present invention is suited for use in spin electronics or detection of spin-polarized electrons.
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公开(公告)号：US20190151424A1
公开(公告)日：2019-05-23
申请号：US16192241
申请日：2018-11-15
Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
Inventor： Edward H. Schuchman , Erich Gulbins , Anthony Futerman , Yael Pewzner-Jung
Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
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公开(公告)号：US20180296675A1
公开(公告)日：2018-10-18
申请号：US15924039
申请日：2018-03-16
Applicant: Memorial Sloan Kettering Cancer Center , Yeda Research and Development Co., Ltd. at the Weizmann Institute of Science
Inventor： Jonathan COLEMAN , Philip A. WATSON , Kwanghee KIM , Avigdor SCHERZ
IPC: A61K41/00 , A61P35/00 , A61K38/08 , A61K31/4166 , A61N5/06
Abstract: A method for treatment of prostate cancer or benign prostate hyperplasia by combination therapy comprising administering to a patient an androgen-deprivation therapy agent and a bacteriochlorophyll derivative followed by photodynamic therapy (PDT) or vascular-targeted photodynamic therapy (VTP).
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公开(公告)号：US09867576B2
公开(公告)日：2018-01-16
申请号：US14935718
申请日：2015-11-09
Applicant: New York University , Yeda Research and Development Co., Ltd. at the Weizmann Institute of Science
Inventor： Uri Hasson , Rafi Malach , David Heeger
CPC classification number: A61B5/7246 , A61B3/11 , A61B3/113 , A61B5/0042 , A61B5/0048 , A61B5/0075 , A61B5/04009 , A61B5/04842 , A61B5/04845 , A61B5/04847 , A61B5/055 , A61B5/1114 , A61B5/1128 , A61B6/037 , A61B2503/12
Abstract: Exemplary embodiments of a system and method can be provided for measuring a level and/or details of how engaging, effective or memorable a stimulus that may be based on information associated with one or more subjects' neuronal, physiological and/or behavioral responses to the stimulus. In addition, an exemplary embodiment of a computer-accessible medium containing executable instructions thereon can also be provided which can be executed by a processing arrangement. For example, when the processing arrangement executes the instructions, the processing arrangement can be configured to, e.g., receive neuronal, physiological and/or behavioral data one or more subjects being presented with stimuli, determine further data associated with a measure of inter-subject similarity of the neuronal, physiological and/or behavioral data, and identify particular portions of the stimuli that meet a pre-determined criteria relating to the further data associated with the measure of inter-subject similarity. In addition, the processing arrangement can be further configured to display and/or store identifiers of the particular portions of the stimuli in a storage arrangement in a user-accessible format and/or a user-readable format.
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Patent Agency Ranking
15.发明申请Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a DNA repair enzyme and a cancer 审中-公开用于确定发展癌症的风险的方法和试剂盒，用于评估癌症治疗的有效性和剂量以及DNA修复酶与癌症的活性之间的相关性公开(公告)号：US20030003454A1
公开(公告)日：2003-01-02
申请号：US09815015
申请日：2001-03-23
Inventor： Zvi Livneh , Tamar Paz-Elizur , Sara Blumenstein
IPC: C12Q001/68 , G01N033/574
CPC classification number: C12Q1/6886 , C12Q2600/106 , G01N33/574 , G01N2333/924 , G01N2333/988 , G01N2800/52
Abstract: Methods and kits for (i) determining a risk of a subject to develop cancer; (ii) evaluating an effectiveness and dosage of cancer therapy administered to a cancer patient; and (iii) determining a presence of correlation or non-correlation between an activity of at least one DNA repair enzyme and at least one cancer, are disclosed.
Abstract translation: 方法和试剂盒，用于（i）确定受试者发展癌症的风险; （ii）评估给予癌症患者的癌症治疗的有效性和剂量; 并且（iii）确定至少一种DNA修复酶与至少一种癌症的活性之间的相关性或非相关性的存在。
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公开(公告)号：US09492514B2
公开(公告)日：2016-11-15
申请号：US14404881
申请日：2013-05-31
Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE , UNIVERSITAET DUISBURG-ESSEN
Inventor： Edward H. Schuchman , Erich Gulbins , Anthony Futerman , Yael Pewzner-Jung
CPC classification number: A61K38/50 , A61K9/0014 , A61K9/0019 , A61K9/0073 , A61K9/12 , A61K45/06 , C12Y305/01023
Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
Abstract translation: 本发明涉及用于治疗或预防患有囊性纤维化，COPD和/或开放性伤口的受试者的病原体感染的方法。 该方法包括选择具有囊性纤维化，COPD和/或开放性伤口的受试者，并在有效减少神经酰胺的病症和治疗或预防病原体感染的条件下向所选受试者施用神经酰胺酶。 该方法还涉及使用神经酰胺酶与其他药物组合以减少感染，减少神经酰胺，或改善囊性纤维化，COPD和/或开放性伤口患者的肺功能。
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公开(公告)号：US20160152568A1
公开(公告)日：2016-06-02
申请号：US14904708
申请日：2014-07-13
Inventor： Milko VAN DER BOOM , Michal LAHAV , Renata BALGLEY , Sreejith SHANKAR POOPANAL
IPC: C07D213/06 , B01D53/02 , B01J20/22
CPC classification number: C07D213/06 , B01D53/02 , B01D2253/204 , B01J20/02 , B01J20/226 , C07D213/53 , C07F1/08 , C07F3/06 , C07F15/0066 , C07F19/00 , C08G83/00 , C08L101/005
Abstract: The present invention provides metal-organic materials, more specifically organometallic polymers, comprising polypyridyl organic ligands such as tetrakis(4-(pyridin-4-ylethynyl)phenyl)methane, tetrakis(4-(2-(pyridin-4-yl)vinyl)phenyl)methane,3,5,7-tetrakis(4-(pyridin-4-ylethynyl)phenyl)adamantane or 1,3,5,7-tetrakis(4-(2-(pyridine-4-yl)vinyl)phenyl)adamantine, and metal ions structurally coordinated with said ligands, and having three-dimensional crystalline micro or sub-micro structure; as well as a method for the preparation thereof. These metal-organic materials are useful as adsorbents in processes for gas adsorption or separation.
Abstract translation: 本发明提供金属 - 有机材料，更具体地说是有机金属聚合物，其包含聚吡啶基有机配体如四（4-（吡啶-4-基乙炔基）苯基）甲烷，四（4-（2-（吡啶-4-基） ）苯基）甲烷，3,5,7-四（4-（吡啶-4-基乙炔基）苯基）金刚烷或1,3,5,7-四（4-（2-（吡啶-4-基）乙烯基） 苯基）金刚烷和与所述配体结构配位的金属离子，并具有三维结晶微亚结构或亚微结构; 以及其制备方法。 这些金属有机材料可用作气体吸附或分离方法中的吸附剂。
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18.发明申请COMPUTER-ACCESSIBLE MEDIUM, SYSTEM AND METHOD FOR ASSESSING EFFECT OF A STIMULUS USING INTERSUBJECT CORRELATION 有权计算机可访问介质，系统和方法，用于评估使用互相关联的刺激的影响公开(公告)号：US20160058392A1
公开(公告)日：2016-03-03
申请号：US14935718
申请日：2015-11-09
Applicant: New York University , Yeda Research and Development Co., Ltd. at the Weizmann Institute of Science
Inventor： URI HASSON , Rafi Malach , David Heeger
CPC classification number: A61B5/7246 , A61B3/11 , A61B3/113 , A61B5/0042 , A61B5/0048 , A61B5/0075 , A61B5/04009 , A61B5/04842 , A61B5/04845 , A61B5/04847 , A61B5/055 , A61B5/1114 , A61B5/1128 , A61B6/037 , A61B2503/12
Abstract: Exemplary embodiments of a system and method can be provided for measuring a level and/or details of how engaging, effective or memorable a stimulus that may be based on information associated with one or more subjects' neuronal, physiological and/or behavioral responses to the stimulus. In addition, an exemplary embodiment of a computer-accessible medium containing executable instructions thereon can also be provided which can be executed by a processing arrangement. For example, when the processing arrangement executes the instructions, the processing arrangement can be configured to, e.g., receive neuronal, physiological and/or behavioral data one or more subjects being presented with stimuli, determine further data associated with a measure of inter-subject similarity of the neuronal, physiological and/or behavioral data, and identify particular portions of the stimuli that meet a pre-determined criteria relating to the further data associated with the measure of inter-subject similarity. In addition, the processing arrangement can be further configured to display and/or store identifiers of the particular portions of the stimuli in a storage arrangement in a user-accessible format and/or a user-readable format.
Abstract translation: 可以提供系统和方法的示例性实施例，用于测量可以基于与一个或多个受试者的神经元，生理和/或行为反应相关联的信息的吸引，有效或难忘的刺激的水平和/或细节 刺激。 此外，还可以提供其上包含可执行指令的计算机可访问介质的示例性实施例，其可以由处理装置执行。 例如，当处理装置执行指令时，处理装置可以被配置为例如接收神经元，生理和/或行为数据，一个或多个被呈现刺激的对象，确定与对象间的度量相关联的进一步的数据 神经元，生理和/或行为数据的相似性，并且识别满足与与受试者间相似性的测量相关联的进一步数据相关的预定准则的刺激的特定部分。 此外，处理装置还可以被配置为以用户可访问的格式和/或用户可读格式在存储装置中显示和/或存储刺激的特定部分的标识符。
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公开(公告)号：US20150051151A1
公开(公告)日：2015-02-19
申请号：US14384685
申请日：2013-03-14
Inventor： Michal Eisenbach-Schwartz , Matityahu Fridkin , Michal Cardon-Yaakov
CPC classification number: C07K7/06 , A61K9/0053 , A61K38/00 , C07K7/64
Abstract: The present application provides synthetic modified peptides of five to seven natural or non-natural amino acids as well as pharmaceutical compositions comprising them, for use in the treatment a disease or disorder presenting behavioral abnormalities associated with impairment of sensory gating function, depression or cognitive impairment, particularly schizophrenia and Alzheimer's disease.
Abstract translation: 本申请提供五至七个天然或非天然氨基酸的合成修饰肽以及包含它们的药物组合物，用于治疗与感觉门控功能障碍，抑郁症或认知障碍相关的行为异常的疾病或病症 ，特别是精神分裂症和阿尔茨海默病。
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