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23 条记录 (耗时 0.186 秒)

    5,6,7-trisubstituted-4-aminopyrido[2,3-D] pyrimidine compounds
    12.
    发明授权
    5,6,7-trisubstituted-4-aminopyrido[2,3-D] pyrimidine compounds 失效
    5,6,7-三取代-4-氨基吡啶并[2,3-D]嘧啶化合物

    公开(公告)号：US6030969A

    公开(公告)日：2000-02-29

    申请号：US58324

    申请日：1998-04-09

    申请人： Shripad S. Bhagwat ,  Richard J. Perner ,  Yu-Gui Gu

    发明人： Shripad S. Bhagwat ,  Richard J. Perner ,  Yu-Gui Gu

    IPC分类号： C07D471/04 ,  A61K31/505

    CPC分类号： C07D471/04

    摘要： A compound having the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, pain, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods for preparation thereof.

    摘要翻译： 具有下式的化合物其中R 1，R 2，R 3，R 4和R 5的定义是通过给予其化合物抑制腺苷激酶的方法，药物组合物，其包含治疗有效量的上述化合物与药学上可接受的载体 ，在需要这种治疗的哺乳动物中治疗脑缺血，癫痫，疼痛，坏死，炎症和败血症的方法，包括向哺乳动物施用治疗有效量的其化合物及其制备方法。

    Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists
    13.
    发明授权
    Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists 失效
    作为多巴胺激动剂的反-2,6-，3,6-和4,6-二氮杂-5,6,6a，7,8,12b-六氢苯并[c]菲化合物

    公开(公告)号：US5668141A

    公开(公告)日：1997-09-16

    申请号：US626654

    申请日：1996-04-02

    申请人： Kazumi Shiosaki ,  Yu Gui Gu ,  Michael Michaelides

    发明人： Kazumi Shiosaki ,  Yu Gui Gu ,  Michael Michaelides

    IPC分类号： C07D471/04 ,  A61K31/445

    CPC分类号： C07D471/04

    摘要： A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached comprise a pyridine ring selected from: ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder, and methods for the preparation thereof.

    摘要翻译： 下式的四环化合物：其中A及其所连接的原子包含选自以下的吡啶环：其中R1，R2和R3具体定义，哪些化合物可用于治疗多巴胺 相关的神经，心理和心血管疾病，以及治疗药物滥用和其他成瘾行为障碍，认知障碍和注意力缺陷障碍及其制备方法。