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1.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 有权乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US08207350B2
公开(公告)日：2012-06-26
申请号：US12259090
申请日：2008-10-27
申请人： Robert F. Keyes , Yu Gui Gu , Hing L. Sham
发明人： Robert F. Keyes , Yu Gui Gu , Hing L. Sham
IPC分类号： A61K31/428 , C07D277/64 , C07D277/74
CPC分类号： C07D277/68 , C07D277/82 , C07D417/12
摘要： The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）的式（I）化合物，可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。
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2.发明申请Novel acetyl-CoA Carboxylase (ACC) Inhibitors and their use in Diabetes, Obesity and Metabolic Syndrome 有权新型乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用公开(公告)号：US20090048298A1
公开(公告)日：2009-02-19
申请号：US12259090
申请日：2008-10-27
申请人： Robert F. Keyes , Yu Gui Gu , Hing L. Sham
发明人： Robert F. Keyes , Yu Gui Gu , Hing L. Sham
IPC分类号： A61K31/4709 , C07D277/62 , C07D409/02 , A61K31/428
CPC分类号： C07D277/68 , C07D277/82 , C07D417/12
摘要： The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）的式（I）化合物，可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。
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公开(公告)号：US06455571B1
公开(公告)日：2002-09-24
申请号：US09421787
申请日：1999-10-19
申请人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
发明人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
IPC分类号： A61K3140
CPC分类号： C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
摘要： Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译： 公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。
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公开(公告)号：US06831096B2
公开(公告)日：2004-12-14
申请号：US10253152
申请日：2002-09-24
申请人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
发明人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
IPC分类号： A61K3140
CPC分类号： C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
摘要： Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译： 公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。
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5.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 有权乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US08735595B2
公开(公告)日：2014-05-27
申请号：US11675406
申请日：2007-02-15
申请人： Yu Gui Gu , Xiangdong Xu , Moshe Weitzberg , Hing L. Sham
发明人： Yu Gui Gu , Xiangdong Xu , Moshe Weitzberg , Hing L. Sham
IPC分类号： A61K31/4439 , A61K31/426 , C07D417/04 , C07D277/34
CPC分类号： C07D277/34 , C07D417/04
摘要： The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）的式（I）化合物，可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。
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公开(公告)号：US06518305B1
公开(公告)日：2003-02-11
申请号：US09422093
申请日：1999-10-19
申请人： Clarence J. Maring , Yuanwei Chen , David A. Degoey , Vincent L. Giranda , David J. Grampovnik , Yu Gui Gu , Warren M. Kati , Dale J. Kempf , April Kennedy , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Gary T. Wang , Sheldon Wang , Ming C. Yeung , Chen Zhao
发明人： Clarence J. Maring , Yuanwei Chen , David A. Degoey , Vincent L. Giranda , David J. Grampovnik , Yu Gui Gu , Warren M. Kati , Dale J. Kempf , April Kennedy , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Gary T. Wang , Sheldon Wang , Ming C. Yeung , Chen Zhao
IPC分类号： A61K31195
CPC分类号： C07D233/64 , C07B2200/07 , C07B2200/09 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07C2601/08 , C07C2601/10 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04
摘要： Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译： 公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。
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7.发明授权Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists 失效作为多巴胺激动剂的反-2,6-，3,6-和4,6-二氮杂-5,6,6a，7,8,12b-六氢苯并[c]菲化合物
公开(公告)号：US5668141A
公开(公告)日：1997-09-16
申请号：US626654
申请日：1996-04-02
申请人： Kazumi Shiosaki , Yu Gui Gu , Michael Michaelides
发明人： Kazumi Shiosaki , Yu Gui Gu , Michael Michaelides
IPC分类号： C07D471/04 , A61K31/445
CPC分类号： C07D471/04
摘要： A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached comprise a pyridine ring selected from: ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder, and methods for the preparation thereof.
摘要翻译： 下式的四环化合物：其中A及其所连接的原子包含选自以下的吡啶环：其中R1，R2和R3具体定义，哪些化合物可用于治疗多巴胺 相关的神经，心理和心血管疾病，以及治疗药物滥用和其他成瘾行为障碍，认知障碍和注意力缺陷障碍及其制备方法。
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8.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 有权乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US07928243B2
公开(公告)日：2011-04-19
申请号：US11950692
申请日：2007-12-05
申请人： Yu Gui Gu , Richard F. Clark , Qun Li , Moshe Weitzberg , Hing Sham
发明人： Yu Gui Gu , Richard F. Clark , Qun Li , Moshe Weitzberg , Hing Sham
IPC分类号： A61K31/426 , C07D277/34
CPC分类号： C07D277/34 , C07C233/18 , C07C233/22
摘要： The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
摘要翻译： 本发明涉及式（I）的化合物：也可用于治疗或预防代谢疾病或病症的药物组合物和方法。
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9.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 失效乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US08748627B2
公开(公告)日：2014-06-10
申请号：US11675410
申请日：2007-02-15
申请人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard F. Clark , Tianyuan Zhang , Qun Li , Todd M. Hansen , Hing Sham , Bruce A. Beutel , Heidi S. Camp , Xiaojun Wang
发明人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard F. Clark , Tianyuan Zhang , Qun Li , Todd M. Hansen , Hing Sham , Bruce A. Beutel , Heidi S. Camp , Xiaojun Wang
IPC分类号： A61K31/427 , A61K31/433 , A61K31/4245 , A61K31/4439 , A61K31/444 , C07D417/12 , C07D417/14 , C07D417/04 , C07D413/12 , C07D413/14
CPC分类号： C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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10.发明申请NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 有权新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用公开(公告)号：US20080161368A1
公开(公告)日：2008-07-03
申请号：US11950692
申请日：2007-12-05
申请人： Yu Gui Gu , Richard F. Clark , Qun Li , Moshe Weitzberg , Hing Sham
发明人： Yu Gui Gu , Richard F. Clark , Qun Li , Moshe Weitzberg , Hing Sham
IPC分类号： A61K31/426 , A61P3/00 , C07C235/00 , C07D277/00 , A61K31/165
CPC分类号： C07D277/34 , C07C233/18 , C07C233/22
摘要： The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
摘要翻译： 本发明涉及式（I）的化合物：也可用于治疗或预防代谢疾病或病症的药物组合物和方法。
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