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公开(公告)号：US20200347043A1
公开(公告)日：2020-11-05
申请号：US16863747
申请日：2020-04-30
Applicant: Calico Life Sciences LLC , AbbVie Inc. , SYGNATURE DISCOVERY LIMITED
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Lei Shi , Kathleen J. Murauski , Xiangdong Xu , Yunsong Tong , John T. Randolph , Michael J. Dart , Hanae Benelkebir , Steven Edeson , Kathryn Starbuck
IPC: C07D413/12 , A61P25/28 , A61K45/06 , A61K31/422 , C07D405/12 , A61K31/4155 , A61K31/403 , C07D311/24 , A61K31/353 , C07D311/22 , A61K31/4433 , A61K31/4245 , C07C235/36 , A61K31/165 , C07D493/08 , A61K31/4025 , C07C235/40 , C07D405/06 , A61K31/397 , C07D407/12 , C07D271/10 , C07D471/04 , A61K31/437
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US08772500B2
公开(公告)日：2014-07-08
申请号：US13658374
申请日：2012-10-23
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt
IPC: C07D213/00 , C07D213/28 , C07D211/74 , C07D421/00 , C07D401/00
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（II）的TRPV3的调节剂：其中G1，X1，X2，X3，X4，X5，G2，Ra，Rb和u如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08772499B2
公开(公告)日：2014-07-08
申请号：US13658355
申请日：2012-10-23
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Eric A. Voight
IPC: C07D213/00 , C07D213/28 , C07D211/74 , C07D421/00 , C07D401/00
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of Formula (I) wherein p is 1, 2, 3, or 4, and G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中p为1,2,3或4，并且G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb和u如 规格。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20130172334A1
公开(公告)日：2013-07-04
申请号：US13716862
申请日：2012-12-17
Applicant: AbbVie Inc.
Inventor： Michael J. Dart , Philip R. Kym , Eric A. Voight , Anurupa Shrestha , Jerome F. Daanen , Tammie K. Jinkerson , Ryan G. Keddy , Sridhar Peddi , Arthur Gomtsyan , Michael E. Kort , Gregory A. Gfesser , Kevin R. Woller , Derek W. Nelson
IPC: C07D405/12 , A61K31/192 , C07D239/80 , C07D413/12 , A61K31/4704 , C07D491/052 , A61K31/517 , A61K31/4709 , A61K31/538 , A61K45/06 , C07D215/38
CPC classification number: C07D405/12 , A61K31/192 , A61K31/4704 , A61K31/4709 , A61K31/517 , A61K31/538 , A61K45/06 , C07D215/227 , C07D215/38 , C07D239/80 , C07D265/36 , C07D413/12 , C07D413/14 , C07D491/052
Abstract: Disclosed herein are compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein X1, L, Rx, Ry, G, Z, A, m, n, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，其中X1，L，Rx，Ry，G，Z，A，m，n和p如说明书中所定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20250115563A1
公开(公告)日：2025-04-10
申请号：US18647747
申请日：2024-04-26
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Yunsong Tong , Xiangdong Xu , Qingwei Zhang , Ramzi Farah Sweis , Michael J. Dart
IPC: C07D271/10 , A61K31/4245 , A61K31/4355 , A61K31/4439 , A61K45/06 , A61P25/28 , C07D233/96 , C07D271/06 , C07D401/12 , C07D413/12 , C07D491/048
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Patent Agency Ranking
公开(公告)号：US20240018133A1
公开(公告)日：2024-01-18
申请号：US18462918
申请日：2023-09-07
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph , Hanae Benelkebir
IPC: C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08
CPC classification number: C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08 , A61K45/06
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20210230195A1
公开(公告)日：2021-07-29
申请号：US17227071
申请日：2021-04-09
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Michael J. Dart , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Kathleen Murauski , Marina Pliushchev , Brian S. Brown , Eric Voight , John T. Randolph
IPC: C07F9/12
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20200345727A1
公开(公告)日：2020-11-05
申请号：US16761390
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC: A61K31/4965 , A61K45/06 , C07D261/18 , C07D263/34 , C07D241/20 , A61K31/421 , A61K31/42 , A61K31/437 , C07D471/04 , C07D487/04 , C07D333/38 , C07D307/68 , A61K31/381 , A61K31/519 , A61K31/341 , A61K31/415 , A61K31/426 , A61K31/425 , C07D275/03 , C07D277/56 , C07D231/14 , C07D495/04 , A61K31/4985 , C07D237/20 , C07D413/04 , C07D285/06 , C07D317/46 , A61K31/36 , A61K31/4245 , A61K31/422 , A61K31/4196 , C07D249/10 , C07D217/26 , A61K31/472 , A61K31/196 , C07C233/62 , C07D401/04 , A61K31/4427 , A61K31/5355
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20250145594A1
公开(公告)日：2025-05-08
申请号：US18251079
申请日：2021-10-29
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Michael J. Dart , Kathleen J. Murauski , John T. Randolph , Lei Shi , Russell C. Smith , Yunsong Tong , Xiangdong Xu , Hanae Benelkebir , Kamaldeep K. Chohan , Steven J. Edeson , Sebastian Schwenk , Kathryn A. Starbuck
IPC: C07D405/14 , A61K31/167 , A61K31/353 , A61K31/397 , A61K31/4025 , A61K31/403 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/44 , A61K31/4433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/538 , A61K31/695 , C07C235/22 , C07D213/65 , C07D231/18 , C07D271/10 , C07D311/66 , C07D403/04 , C07D405/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D493/08 , C07F7/10
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.
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公开(公告)号：US20240307382A1
公开(公告)日：2024-09-19
申请号：US18330185
申请日：2023-06-06
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC: A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
CPC classification number: A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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