公开(公告)号：US20170261524A1

公开(公告)日：2017-09-14

申请号：US15450135

申请日：2017-03-06

Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD. ,  AJINOMOTO CO., INC.

Inventor： Masako HAYAKAWA ,  Kazutaka SHIMBO ,  Hiroo YOSHIDA

IPC: G01N33/96 ,  G01N33/68

CPC classification number: G01N33/96 ,  G01N33/6806 ,  G01N33/6848 ,  G01N2030/042 ,  G01N2496/80 ,  Y10T436/105831 ,  Y10T436/106664

Abstract: An external standard solution for use in the analysis of amino acid in plasma, containing, (1) at least one amino acid selected from the following components A, at a concentration of 0.0007 M to 0.49 M, and (2) (i) at least one amino acid selected from the following components B, at a concentration of 0.2 to 0.9 times of the lowest-concentration amino acid among the amino acids selected from components A, (ii) at least one amino acid selected from the following components C, at a concentration of 0.1 to 0.4 times of the lowest-concentration amino acid among amino acids selected from the components A, or (iii) at least one amino acid selected from the following components D, at a concentration of 0.05 to 0.2 times of the lowest-concentration amino acid among amino acids selected from the components A; [Components A] valine, glycine, alanine and glutamine [Components B] serine, proline, threonine, taurine, leucine, isoleucine, lysine, histidine, phenylalanine and tyrosine [Components C] asparagine, ornithine, arginine and tryptophan [Components D] glutamic acid, methionine, citrulline and cystine.

公开(公告)号：US20220088111A1

公开(公告)日：2022-03-24

申请号：US17548044

申请日：2021-12-10

Applicant: AJINOMOTO CO., INC.

Inventor： Yoshiro KITAHARA ,  Yoriko OKAMATSU ,  Kazutaka SHIMBO ,  Naoko ARASHIDA ,  Ayaka SHIRASAWA

IPC: A61K38/01

Abstract: Peptides consisting of the amino acid sequence of any of LIVTQTMKGL (SEQ ID NO: 1), LIVTQTMKG (SEQ ID NO: 2), LIVTQTMK (SEQ ID NO: 3), IVTQTMKGL (SEQ ID NO: 4), IVTQTMKG (SEQ ID NO: 5), and VTQTMKGL (SEQ ID NO: 6) are useful for improving intestinal barrier function, for suppressing blood glucose elevation, for improving insulin sensitivity, for promoting FGF21 secretion, for suppressing stress or protecting nerves, or for reducing fatigue.

公开(公告)号：US20210239714A1

公开(公告)日：2021-08-05

申请号：US17237314

申请日：2021-04-22

Applicant: Ajinomoto Co., Inc.

Inventor： Chiori IJICHI ,  Kenji KONDO ,  Ayaka SHIRASAWA ,  Kunio NAKATA ,  Kazutaka SHIMBO ,  Yutaka MARUYAMA ,  Yayoi KAWATO

IPC: G01N33/68 ,  G01N33/558

Abstract: Measuring the amount of lipocalin 15 in an olfactory mucosa sample or an olfactory mucus sample taken from a mammal is useful for non-subjectively and objectively diagnosing olfactory sense and is easily applied to clinical practice.

公开(公告)号：US20190277862A1

公开(公告)日：2019-09-12

申请号：US16239817

申请日：2019-01-04

Applicant: AJINOMOTO CO., INC.

Inventor： Takeshi IKEUCHI ,  Nobuhiro KAWAI ,  Yuki YANO ,  Naoko ARASHIDA ,  Rumi NISHIMOTO ,  Kazutaka SHIMBO

IPC: G01N33/68

Abstract: An evaluating method includes an evaluating step of evaluating a state of mild cognitive impairment or Alzheimer's disease for a subject to be evaluated using a concentration value of at least one of α-ABA, Ala, Arg, Asn, Cit, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Cysteine, Taurine, GABA, Hypotaurine, S-Adenosyl homocysteine, Sarcosine, Serotonin, Spermidine, hCit, 3-hKyn, aAiBA, N8-Acetylspermidine, Phosphoserine, bABA, ADMA, and Thioproline in blood of the subject.

公开(公告)号：US20190227071A1

公开(公告)日：2019-07-25

申请号：US16373193

申请日：2019-04-02

Applicant: AJINOMOTO CO., INC.

Inventor： Hidehiro NAKAMURA ,  Natsumi NISHIKATA ,  Akira IMAIZUMI ,  Kazutaka SHIMBO ,  Naoko ARASHIDA ,  Rumi NISHIMOTO

IPC: G01N33/574 ,  G01N33/49 ,  G01N33/487

Abstract: An evaluating method includes an evaluating step of evaluating a state of pancreatic cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of N-Me-bABA, bABA, GABA, N6-Acetyl-L-Lys, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, Homoarginine, Hypotaurine, Kinurenine, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.

公开(公告)号：US20160139134A1

公开(公告)日：2016-05-19

申请号：US15003235

申请日：2016-01-21

Applicant: AJINOMOTO CO., INC.

Inventor： Hiroshi MIYANO ,  Akihisa YAHASHI ,  Kazutaka SHIMBO ,  Masakazu NAKAZAWA ,  Kazuo HIRAYAMA

IPC: G01N33/58 ,  C07D207/46 ,  G01N33/68

CPC classification number: G01N33/58 ,  C07D207/46 ,  G01N33/6803 ,  G01N33/6806 ,  G01N33/6848 ,  G01N2458/15 ,  G01N2560/00 ,  Y10T436/13 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/24

Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.

Abstract translation: 本发明提供了用于分析样品中所含的氨基（例如氨基酸或肽）的化合物的方法，并且以高灵敏度方便地进行分析。 含有氨基化合物的样品中具有氨基的化合物用特定的氨基甲酸酯化合物如对三甲基铵苯乙烯基-N-羟基琥珀酰亚胺基氨基甲酸酯碘化物进行标记以提高选择性和灵敏度。 本发明优选与诸如MS / MS方法的质谱结合使用以促进定量分析。 本发明还提供用于质谱的标记试剂。