公开(公告)号：US20190275241A1

公开(公告)日：2019-09-12

申请号：US16297408

申请日：2019-03-08

Applicant: AMGEN INC.

Inventor： Lawrence S. Ring ,  Tohid Pirbodaghi ,  Samin Akbari ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Mark Gordon ,  Mikhail Tikh ,  Jimmie L. Ward ,  Scott R. Gibson ,  Sheldon B. Moberg ,  Joshua Tamsky ,  Paul Faucher

IPC: A61M5/168 ,  A61M5/158 ,  A61M39/24

Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.

公开(公告)号：US12109389B2

公开(公告)日：2024-10-08

申请号：US17256240

申请日：2019-07-12

Applicant: AMGEN INC.

Inventor： Matthew Wayne Janke ,  Sudeshna Dutta Ray ,  Scott R. Gibson ,  Daniel Eduardo Groszmann ,  Wael Mismar ,  Mehran Mojarrad ,  Robert Allen Dees ,  Paul Daniel Faucher

IPC: A61M5/14 ,  A61M5/145 ,  A61M5/162 ,  A61M39/22 ,  A61M5/158

CPC classification number: A61M5/1452 ,  A61M5/1626 ,  A61M39/221 ,  A61M2005/1585 ,  A61M2205/52

Abstract: Fluid path assemblies for drug delivery devices and methods of establishing a fluid flow path for drug delivery devices are described that include a needle shield valve member that couples to a reservoir having a needle mounted thereto. The needle shield valve member includes an internal barrier that protects the needle and/or contains a drug within the reservoir until activation of the drug delivery device. Upon activation, there is relative movement between the reservoir and needle shield valve member until the needle pierces the barrier to establish a fluid flow path from the reservoir through the needle shield valve member.

公开(公告)号：US20240066206A1

公开(公告)日：2024-02-29

申请号：US17767475

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Heejin Lee ,  Daniel Eduardo Groszmann ,  Sheldon B. Moberg ,  Mohammad Bonakdar ,  Rasmus Ohlenschlaeger

IPC: A61M5/142

CPC classification number: A61M5/142 ,  A61M2205/123 ,  A61M2205/3368 ,  A61M2205/3633 ,  A61M2205/584 ,  A61M2205/585 ,  A61M2207/00

Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle assembly, and a temperature indicator. The housing defines an inner volume and includes at least one opening. The container contains a medicament which is urged out of the container by the activation mechanism. The needle assembly has a needle and/or a cannula to deliver the medicament from the container. The temperature indicator is operably coupled with the outer surface of the container and is responsive to a change in temperature of the container.

公开(公告)号：US20230173198A1

公开(公告)日：2023-06-08

申请号：US17911545

申请日：2021-02-08

Applicant: AMGEN INC.

Inventor： Mohammad Bonakdar ,  Daniel Eduardo Groszmann ,  Heejin Lee ,  Leonela Sabrina Vega Loaisa

IPC: A61M5/46 ,  A61M5/32

CPC classification number: A61M5/46 ,  A61M5/3293 ,  A61M5/322 ,  A61M2205/3306 ,  A61M2205/50

Abstract: Drug delivery member insertion depth sensing assemblies, drug delivery devices, and methods for determining an insertion depth of a drug delivery member are disclosed. The sensing assemblies can include electrical sensing assemblies with direct or indirect measurement components or optical sensing assemblies with one or more light sources and one or more photodiodes. A controller of the sensing assemblies can receive data associated with the drug delivery member in an insertion position. The data can then be correlated to an insertion depth of the drug delivery member.

公开(公告)号：US11083840B2

公开(公告)日：2021-08-10

申请号：US15995442

申请日：2018-06-01

Applicant: AMGEN INC.

Inventor： Scott Robert Gibson ,  Sudeshna Dutta Ray ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Nathan Thomas Balcom ,  Alejandro Campillo-Agusti ,  Alan D. Payne ,  Lawrence Scott Ring

IPC: A61M5/162 ,  A61M39/14 ,  A61M5/145 ,  A61M5/32 ,  A61M5/158

Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

公开(公告)号：US20210060259A1

公开(公告)日：2021-03-04

申请号：US16961762

申请日：2019-01-17

Applicant: AMGEN INC.

Inventor： Sudeshna Dutta Ray ,  Scott R. Gibson ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Robert Allen Dees ,  Jonathan Dean Johnson ,  Antonio S. Murcia

IPC: A61M5/315 ,  A61M5/20

Abstract: A flexible plunger rod, drug delivery mechanism, drug delivery device, and methods are described that utilize the flexible plunger rod perform drug delivery operations. In embodiments, the flexible plunger rod can be stored in a curved configuration to thereby reduce a footprint of the drug delivery mechanism and device.

公开(公告)号：US20200238006A1

公开(公告)日：2020-07-30

申请号：US16745693

申请日：2020-01-17

Applicant: AMGEN INC.

Inventor： Daniel Eduardo Groszmann ,  Scott Robert Gibson

IPC: A61M5/168 ,  A61M5/24 ,  A61M5/315 ,  A61M5/142 ,  A61M5/20

Abstract: Systems and methods for injecting a drug and detecting tissue induced back pressure are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, an administration member connected or connectable in fluid communication with the reservoir, a drive assembly, and a pressure sensor. The administration member may be configured for insertion into and subsequently retraction from a patient. The drive assembly may be configured to urge the drug from the reservoir to deliver a dose of the drug to the patient via the administration member. The pressure sensor may be configured to detect tissue back pressure during use of the drug delivery system, including after dose completion and prior to retraction of the administration member. The drug delivery system may be controlled in a manner that accounts for the tissue back pressure measurement.