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公开(公告)号：US10532109B2
公开(公告)日：2020-01-14
申请号：US16301888
申请日：2017-05-08
Inventor： Shengxi Chen , Yanmin Zhang , Sidney Hecht
Abstract: Provided herein are therapeutic agents having specificity for having inhibitory activity against cancer cells that overexpress human epidermal growth factor receptor (HER) genes, including therapeutic agents comprising one or more HER-targeting peptides, pharmaceutical compositions comprising such therapeutic agents, and methods of using such compositions to treat or prevent a cancer or other disease condition associated with HER overexpression.
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公开(公告)号：US10472340B2
公开(公告)日：2019-11-12
申请号：US15550282
申请日：2016-02-17
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Indrajit Bandyopadhyay
IPC: A61K31/5415 , C07D279/18 , C07D279/20 , C07D417/04 , C07D417/14
Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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公开(公告)号：US11712467B2
公开(公告)日：2023-08-01
申请号：US17743058
申请日：2022-05-12
Inventor： Yung Chang , Sidney Hecht , Joseph Leal , Viswanath Arutla , Xiaowei Liu , Sriram Sokalingam
IPC: A61K39/385 , G16B15/00 , G16B20/30 , G16B20/00 , C07D401/14 , A61K47/64 , G01N33/94 , A61K39/00 , G16B15/30
CPC classification number: A61K39/385 , A61K39/0013 , A61K47/646 , C07D401/14 , G01N33/946 , G16B15/00 , G16B15/30 , G16B20/00 , G16B20/30 , A61K2039/6012
Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.
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Patent Agency Ranking
14.发明申请公开(公告)号：US20220265838A1
公开(公告)日：2022-08-25
申请号：US17630994
申请日：2020-07-22
Inventor： Sidney Hecht , Shengxi Chen
Abstract: Provided herein are therapeutic agents having specificity for having inhibitory activity against cancer cells that overexpress human epidermal growth factor receptor (HER) genes, including therapeutic agents comprising one or more HER-targeting peptides, pharmaceutical compositions comprising such therapeutic agents, and methods of using such compositions to treat or prevent a cancer or other disease condition associated with HER overexpression.
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公开(公告)号：US20210403983A1
公开(公告)日：2021-12-30
申请号：US17370859
申请日：2021-07-08
Inventor： Shengxi Chen , Sidney Hecht , Mingxuan Gao
IPC: C12Q1/6806 , C12Q1/70 , C12Q1/686 , C12Q1/6818 , C12Q1/682
Abstract: Described herein are compositions that may be used to detect viral nucleic acid. For example, these compositions may comprise a DNA-nanostructure, a capture oligonucleotide and a protector oligonucleotide, wherein the components are designed based on a duo-toehold-mediated displacement reaction (duo-TMDR) strategy. In this strategy, a first TMDR can switch off a Faster resonance energy transfer (FRET) process and a second TMDR can release the target viral nucleic acid and amplify the signal. Methods of using such compositions are also provided herein.
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16.发明授权公开(公告)号：US11203583B2
公开(公告)日：2021-12-21
申请号：US16784202
申请日：2020-02-06
Inventor： Arnaud Chevalier , Omar Khdour , Yanmin Zhang , Sidney Hecht
IPC: C07D321/00 , C07D311/06 , C07D311/58 , C07D403/08 , C07D405/04 , C07D413/04 , C07D417/04 , C07D487/14 , C07D493/10 , A61K47/54 , A61K49/00 , G01N33/58
Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.
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公开(公告)号：US20180371526A1
公开(公告)日：2018-12-27
申请号：US16016086
申请日：2018-06-22
Inventor： Shengxi Chen , Sidney Hecht , Mingxuan Gao
IPC: C12Q1/6806 , C12Q1/686 , C12Q1/70
Abstract: Described herein are compositions that may be used to detect viral nucleic acid. For example, these compositions may comprise a DNA-nanostructure, a capture oligonucleotide and a protector oligonucleotide, wherein the components are designed based on a duo-toehold-mediated displacement reaction (duo-TMDR) strategy. In this strategy, a first TMDR can switch off a Foster resonance energy transfer (FRET) process and a second TMDR can release the target viral nucleic acid and amplify the signal. Methods of using such compositions are also provided herein.
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公开(公告)号：US09884114B2
公开(公告)日：2018-02-06
申请号：US15189930
申请日：2016-06-22
Inventor： Yung Chang , Sidney Hecht , Joseph Leal , Viswanath Arutla , Xiaowei Liu , Sriram Sokalingam
IPC: A61K39/385 , C07D401/14 , G06F19/16 , G06F19/18 , A61K47/64
CPC classification number: A61K39/385 , A61K39/0013 , A61K47/646 , A61K2039/6012 , C07D401/14 , G01N33/946 , G06F19/16 , G06F19/18
Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.
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