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公开(公告)号：US20140107761A1
公开(公告)日：2014-04-17
申请号：US13998194
申请日：2013-10-09
发明人： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian , Anthony J. Abbate , Klaus Kleine , Stephen Schaible , Jonathan P. Durcan , Thierry Glauser , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth , Yunbing Wang , Daniel Castro , David Wrolstad
IPC分类号： A61F2/82
CPC分类号： A61F2/90 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61L31/06 , A61L31/14 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4823 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , C08L67/04
摘要： Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
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公开(公告)号：US09750622B2
公开(公告)日：2017-09-05
申请号：US14307440
申请日：2014-06-17
CPC分类号： A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
摘要： Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
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公开(公告)号：US20170086737A1
公开(公告)日：2017-03-30
申请号：US15373335
申请日：2016-12-08
CPC分类号： A61B5/4851 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61F2/91 , A61L29/146 , A61L29/18 , A61L31/146 , A61L31/18 , G01B9/02091 , H01L21/0337 , H01L21/31144
摘要： An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.
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公开(公告)号：US20160375179A1
公开(公告)日：2016-12-29
申请号：US14750913
申请日：2015-06-25
CPC分类号： A61L31/06 , A61F2/844 , A61F2/915 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2230/0069 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L67/04
摘要： Methods of fabricating a stent are disclosed including forming a primer layer on a surface of the scaffold including a first polylactide polymer. The primer layer includes a second polylactide polymer and is free of a therapeutic agent. The scaffold with the primer layer is thermally treated to condition the scaffold. A therapeutic layer is formed over the primer layer and the therapeutic layer includes the second polylactide polymer and a drug. The scaffold is crimped and the primer layer improves adhesion of the therapeutic layer to the scaffold and reduces or prevents damage to the therapeutic layer during crimping.
摘要翻译： 公开了制造支架的方法，包括在包括第一聚丙交酯聚合物的支架表面上形成底漆层。 底漆层包括第二聚丙交酯聚合物并且不含治疗剂。 将具有底漆层的支架进行热处理以调节支架。 在底漆层上形成治疗层，治疗层包括第二聚丙交酯聚合物和药物。 支架被卷曲，并且底漆层改善治疗层对支架的粘附，并减少或防止在卷曲期间对治疗层的损伤。
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15.发明申请HIGH MOLECULAR WEIGHT POLYLACTIDE AND POLYCAPROLACTONE COPOLYMER AND BLENDS FOR BIORESORBABLE VASCULAR SCAFFOLDS 有权高分子量聚合物和聚碳酸酯共聚物和可生物降解血管的混合物公开(公告)号：US20150359648A1
公开(公告)日：2015-12-17
申请号：US14307440
申请日：2014-06-17
CPC分类号： A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
摘要： Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
摘要翻译： 由具有高分子量聚合物的聚丙交酯和聚己内酯的组合制成的可生物再吸收的聚合物血管支架，在选定范围内的薄支柱和足够的径向强度以在部署时支撑血管。 支架具有有助于血管愈合的分子量，径向强度和质量的降解行为，包括向容器提供通畅性，降低径向强度，分解和再吸收以允许血管返回到自然状态。
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公开(公告)号：US20130187313A1
公开(公告)日：2013-07-25
申请号：US13734879
申请日：2013-01-04
发明人： Thierry Glauser , Vincent Gueriguian , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth
CPC分类号： B29D22/00 , A61F2/91 , B29C49/0005 , B29C49/02 , B29C49/04 , B29C49/08 , B29C49/78 , B29C55/26 , B29C2793/009 , B29K2995/004 , B29K2995/0041 , B29K2995/0046 , B29K2995/0056 , B29K2995/006 , B29K2995/0077 , B29K2995/0089 , B29L2031/7542
摘要： Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stem manufacture and fabrication of a stent therefrom are disclosed.
摘要翻译： 公开了扩展聚合物管的方法，其具有用于茎的制造和制造支架的所需或最佳形态和机械性能。
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