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    IONTOPHORETIC ELECTROTRANSPORT DEVICE
    11.
    发明申请
    IONTOPHORETIC ELECTROTRANSPORT DEVICE 审中-公开
    静电电动装置

    公开(公告)号：US20090281475A1

    公开(公告)日：2009-11-12

    申请号：US12305381

    申请日：2007-06-11

    申请人： Giovanni Nisato ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson

    发明人： Giovanni Nisato ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson

    IPC分类号： A61N1/30

    CPC分类号： A61N1/044 ,  A61N1/0448 ,  A61N1/325

    摘要： An electrotransport device for transdermal drug delivery has a number of electrodes and driving circuitry for supplying driving signals to the number of electrodes. The electrodes are connected to the driving circuitry in rows and columns. The driving circuitry has row driving circuitry for supplying a row signal to a row of electrodes, and column driving circuitry for supplying a column signal to a column of electrodes. A predetermined electrode is individually addressable by supplying a row signal to a corresponding row of electrodes and a column signal to a corresponding column of electrodes.

    摘要翻译： 用于透皮药物递送的电输送装置具有多个电极和用于向电极数提供驱动信号的驱动电路。 电极以行和列连接到驱动电路。 驱动电路具有用于向一行电极提供行信号的行驱动电路和用于向列电极提供列信号的列驱动电路。 通过向对应的电极列提供行信号和列信号，预定电极可单独寻址。

    DEVICE AND METHOD FOR THE CONTROLLED RELEASE OF A PREDEFINED QUANTITY OF A SUBSTANCE
    12.
    发明申请
    DEVICE AND METHOD FOR THE CONTROLLED RELEASE OF A PREDEFINED QUANTITY OF A SUBSTANCE 审中-公开
    用于控制释放物质的预定数量的装置和方法

    公开(公告)号：US20090131918A1

    公开(公告)日：2009-05-21

    申请号：US12299128

    申请日：2007-04-24

    申请人： Franciscus Paulus Maria Budzellar ,  Mark Thomas Johnson ,  Marc Wilhelmus Gijsbert Ponjee ,  Ralph Kurt

    发明人： Franciscus Paulus Maria Budzellar ,  Mark Thomas Johnson ,  Marc Wilhelmus Gijsbert Ponjee ,  Ralph Kurt

    IPC分类号： A61K9/22

    CPC分类号： A61K9/0097 ,  A61M5/14276 ,  A61M5/172 ,  A61M2205/0244

    摘要： This invention provides a device for the controlled release of a predefined quantity of a substance and a method of controllably releasing a predefined quantity of a substance from a compartment (20). The device comprises a first number of compartments in a substrate (11), each compartment being closed by at least one release mechanism (30). The device further comprises a second number of actuating contacts (40) for the release of the substance from one compartment of the first number of compartments by means of applying an actuation signal between at least a first actuation contact and a second actuation contact of the second number of actuation contacts, wherein the first number exceeds the second number, and each of the actuation contacts comprises at least one conductor path in or on the substrate forelectrically connecting at least one compartment, and the actuation contacts form a mesh-like structure in or on the substrate.

    摘要翻译： 本发明提供了一种用于控制释放预定量物质的装置以及从隔间（20）可控释放预定量物质的方法。 该装置包括在基板（11）中的第一数量的隔室，每个隔室由至少一个释放机构（30）封闭。 该装置还包括第二数量的致动触头（40），用于通过在至少第一致动触点和第二触发器的第二触发触点之间施加致动信号来释放物质从第一数量的隔室的一个隔室 致动触点的数量，其中第一数量超过第二数量，并且每个致动触头包括至少一个导体路径，其中至少一个导体路径在基板中或基板上，以至少一个隔间连接，并且致动触头在其中形成网状结构， 在基板上。

    METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION
    16.
    发明申请
    METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION 审中-公开
    用于检测前辐射的方法和系统

    公开(公告)号：US20100096561A1

    公开(公告)日：2010-04-22

    申请号：US12443863

    申请日：2007-10-03

    申请人： Mark Thomas Johnson ,  Marc Wilhelmus Gijsbert Ponjee ,  Marcello Leonardo Mario Balistreri ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Derk Jan Wilfred Klunder

    发明人： Mark Thomas Johnson ,  Marc Wilhelmus Gijsbert Ponjee ,  Marcello Leonardo Mario Balistreri ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Derk Jan Wilfred Klunder

    IPC分类号： G01N21/01 ,  G01J1/58

    CPC分类号： G01N21/6428 ,  B01L3/5027 ,  G01N21/6454

    摘要： A radiation detection system (100) is described comprising a measurement region (104) in a measurement chamber adapted for receiving at least one sample (108) to be examined and adapted for receiving excitation radiation for impingement on the at least one sample (108) and for generating sample radiation. The radiation detection system (100) furthermore comprises at least one detector element (106) for detection of the generated sample radiation. The radiation detection system thereby is a front irradiation system, i.e. the excitation radiation is incident on a first side of the measurement region (104) in a measurement chamber and the at least one detector element (106) is positioned at a second side of the measurement region (104) in a measurement chamber, the second side being opposite to the first side with respect to the measurement region (104) in a measurement chamber, such that detection occurs at the side facing the first side. The detection system (100) also comprises optical means (112) adapted for guiding said excitation radiation aside the at least one detector element (106).

    摘要翻译： 描述了辐射检测系统（100），其包括在测量室中的测量区域（104），其适于接收待检查的至少一个样品（108）并适于接收用于冲击至少一个样品（108）的激发辐射， 并用于产生样品辐射。 辐射检测系统（100）还包括用于检测所产生的样品辐射的至少一个检测器元件（106）。 因此，辐射检测系统是前照射系统，即激发辐射入射在测量室中的测量区域（104）的第一侧上，并且所述至少一个检测器元件（106）位于第二侧 测量室中的测量区域（104），第二侧在测量室中相对于测量区域（104）与第一侧相对，使得在面向第一侧的一侧发生检测。 检测系统（100）还包括适于将所述激发辐射引导到所述至少一个检测器元件（106）旁边的光学装置（112）。

    RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION
    17.
    发明申请
    RADIATION DETECTORS USING EVANESCENT FIELD EXCITATION 审中-公开
    使用现场激励的辐射探测器

    公开(公告)号：US20090284746A1

    公开(公告)日：2009-11-19

    申请号：US12373995

    申请日：2007-07-04

    申请人： Derk Jan Wilfred Klunder ,  Maarten Marinus Johannes Wilhelm Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson

    发明人： Derk Jan Wilfred Klunder ,  Maarten Marinus Johannes Wilhelm Van Herpen ,  Marcello Leonardo Mario Balistreri ,  Marc Wilhelmus Gijsbert Ponjee ,  Mark Thomas Johnson

    IPC分类号： G01N21/55 ,  G01N21/62

    CPC分类号： G01N21/6454 ,  B01L3/5027 ,  G01N21/6428 ,  G01N21/648 ,  G01N2021/7786

    摘要： A detection system (100, 150, 180, 200, 220, 250) for detecting luminescence from at least one sample (108) when excited by incident excitation radiation. Detecting luminescence may allow to detect, for example, biological, chemical or bio-chemical particles. The detection system (100, 150, 180, 200, 220, 250) comprising at least one optical component (102) with at least a first surface (104). The first surface (104) of the at least one optical component (102) is located to internally reflect incident excitation radiation to create an evanescent field outside the at least one optical component (102) for exciting the at least one sample (108). The detection system also comprises at least one detector element (110) that is in direct contact with the at least one optical component (102) to detect the luminescence from at least one excited sample (108) through the at least one optical component (102).

    摘要翻译： 用于当由入射激发辐射激发时用于检测来自至少一个样品（108）的发光的检测系统（100,150,180,200,250,250）。 检测发光可以允许检测例如生物，化学或生物化学颗粒。 所述检测系统（100,150,180,200,250,250）包括具有至少第一表面（104）的至少一个光学部件（102）。 所述至少一个光学部件（102）的第一表面（104）位于内部反射入射的激发辐射，以在所述至少一个光学部件（102）外部产生消逝场，用于激发所述至少一个样品（108）。 检测系统还包括至少一个与至少一个光学部件（102）直接接触的检测器元件（110），以检测来自至少一个激发的样品（108）的至少一个光学部件（102）的发光 ）。

    Microelectronic sensor device for DNA detection
    18.
    发明授权
    Microelectronic sensor device for DNA detection 有权
    用于DNA检测的微电子传感器装置

    公开(公告)号：US08815162B2

    公开(公告)日：2014-08-26

    申请号：US12303448

    申请日：2007-05-24

    申请人： Erik Robbert Vossenaar ,  Marc Wilhelmus Gijsbert Ponjee ,  Hendrik Roelof Stapert ,  Mark Thomas Johnson

    发明人： Erik Robbert Vossenaar ,  Marc Wilhelmus Gijsbert Ponjee ,  Hendrik Roelof Stapert ,  Mark Thomas Johnson

    IPC分类号： G05D23/00

    CPC分类号： G01N21/6454 ,  B01L3/5027 ,  B01L3/50851 ,  B01L7/525 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/6825 ,  G01N21/0332 ,  G01N21/6428 ,  G01N2021/6439 ,  C12Q2565/1015 ,  C12Q2527/101 ,  C12Q2527/107

    摘要： The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and/or for a controlled melting of hybridizations. The reactant (10) and/or the target substance (20) comprises a label (12) with an observable property, like fluorescence, that changes if the target substance (20) is bound to the reactant (10), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label (12) may preferably be transferred by FRET to a different fluorescent label (22) or quenched if the target substance (20) is bound.

    摘要翻译： 本发明涉及一种微电子传感器装置和一种用于研究生物靶物质（20）的方法，例如DNA片段等寡核苷酸。 在一个实施方案中，所述装置包括反应表面（RS），目标特异性反应物（10）附着到所述反应表面（RS），并且位于样品室（SC）和选择性可控制的加热元件（HE）阵列之间。 样品室（SC）中的温度曲线可以根据需要进行控制，以提供例如PCR和/或受控熔化杂交的条件。 反应物（10）和/或目标物质（20）包含具有可观察性质（如荧光）的标记物（12），如果目标物质（20）与反应物（10）结合，则其变化，所述性质被检测 通过传感器元件阵列，例如光电传感器（SE）。 标记物（12）的荧光优选通过FRET转移到不同的荧光标记物（22），或者如果靶物质（20）被结合则被淬灭。