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    Anti-activin A antibodies and uses thereof
    11.
    发明授权
    Anti-activin A antibodies and uses thereof 有权

    公开(公告)号：US11542325B2

    公开(公告)日：2023-01-03

    申请号：US16128831

    申请日：2018-09-12

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: A61K39/395 ,  A61K39/00 ,  C07K16/22

    Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
    13.
    发明申请
    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：US20180371073A1

    公开(公告)日：2018-12-27

    申请号：US16128831

    申请日：2018-09-12

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K16/22 ,  A61K39/00

    Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    Anti-activin A antibodies and uses thereof
    19.
    发明授权
    Anti-activin A antibodies and uses thereof 有权

    公开(公告)号：US10100109B2

    公开(公告)日：2018-10-16

    申请号：US15346617

    申请日：2016-11-08

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K16/00 ,  C07K16/42 ,  C07K16/22 ,  A61K39/00

    Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

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