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公开(公告)号：US07176191B2
公开(公告)日：2007-02-13
申请号：US10937094
申请日：2004-09-08
IPC分类号： A61K31/66
CPC分类号： A61K31/66 , A01N57/12 , A01N57/16 , A61K9/0014 , A61K31/70
摘要： The present invention provides protonated compounds having antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi.
摘要翻译： 本发明提供具有抗微生物活性的质子化化合物。 本发明还提供包含本发明的质子化化合物的抗微生物组合物。 本发明的质子化化合物为细菌和机会真菌的抗性菌株提供有效的抗微生物活性。
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公开(公告)号：US20050025815A1
公开(公告)日：2005-02-03
申请号：US10644969
申请日：2003-08-21
申请人： Roderic Dale , Steven Gatton , Amy Arrow
发明人： Roderic Dale , Steven Gatton , Amy Arrow
IPC分类号： C12N15/09 , A01N43/04 , A01N57/16 , A61B17/04 , A61F13/00 , A61K8/00 , A61K8/60 , A61K9/08 , A61K9/14 , A61K9/70 , A61K31/675 , A61K31/70 , A61K31/7024 , A61K31/7068 , A61K31/7076 , A61K31/7125 , A61K47/12 , A61K48/00 , A61K51/00 , A61L15/16 , A61P31/02 , A61P31/04 , A61Q19/00 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/02 , C12Q1/68
CPC分类号： A01N57/16 , A61B17/06166 , A61B2017/00893 , A61K8/606 , A61K31/70 , A61L15/46 , A61L17/005 , A61L17/04 , A61L17/105 , A61L24/0015 , A61L24/106 , A61L27/54 , A61L27/60 , A61L2300/258 , A61L2300/404 , A61Q19/00
摘要： The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either on its surface, or integrated into the device. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule. The nucleic acids used in the invention are protonated/acidified to give a pH when dissolved in water of less than pH 7 to about 1, more preferably less than pH 4.5 to about 1, and even more preferably less than pH 2 to about 1.
摘要翻译： 本发明提供了用于管理局部损伤感染的装置和组合物，每个装置和组合物在其表面上含有质子化/酸化的核酸或整合到装置中。 这些修饰的核酸在不考虑细菌类的情况下作为杀菌剂和/或抑菌剂是有效的，因此当诊断困难时或当存在多种感染性生物时特别有用。 本发明的核酸的抗生素活性不依赖于核酸的特定序列或核酸分子的长度。 本发明中使用的核酸被质子化/酸化，当溶解在低于pH7至约1，更优选小于pH 4.5至约1，甚至更优选小于pH 2至约1的水中时产生pH。
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公开(公告)号：US6015886A
公开(公告)日：2000-01-18
申请号：US795926
申请日：1997-02-05
CPC分类号： C07H21/00
摘要： This invention relates to synthetic oligonucleotides that are useful for antisense based therapeutic applications. The synthetic oligonucleotides of this invention have modifications in the sugar phosphate backbone for improved antisense properties.
摘要翻译： 本发明涉及可用于基于反义的治疗应用的合成寡核苷酸。 本发明的合成寡核苷酸在糖磷酸酯骨架中具有改进的反义性质。
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公开(公告)号：US08916529B2
公开(公告)日：2014-12-23
申请号：US11673486
申请日：2007-02-09
申请人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
发明人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
IPC分类号： C12N15/113 , A61K38/00
CPC分类号： C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要： The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
摘要翻译： 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。
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公开(公告)号：US08435960B2
公开(公告)日：2013-05-07
申请号：US12130405
申请日：2008-05-30
申请人： Roderic M. K. Dale , Steven L. Gatton , Amy Arrow
发明人： Roderic M. K. Dale , Steven L. Gatton , Amy Arrow
CPC分类号： A01N57/16 , A61B17/06166 , A61B2017/00893 , A61K8/606 , A61K31/70 , A61L15/46 , A61L17/005 , A61L17/04 , A61L17/105 , A61L24/0015 , A61L24/106 , A61L27/54 , A61L27/60 , A61L2300/258 , A61L2300/404 , A61Q19/00
摘要： The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either on its surface, or integrated into the device. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule. The nucleic acids used in the invention are protonated/acidified to give a pH when dissolved in water of less than pH 7 to about 1, more preferably less than pH 4.5 to about 1, and even more preferably less than pH 2 to about 1.
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公开(公告)号：US06627215B1
公开(公告)日：2003-09-30
申请号：US09281858
申请日：1999-03-31
申请人： Roderic M. K. Dale , Steven L. Gatton , Amy Arrow
发明人： Roderic M. K. Dale , Steven L. Gatton , Amy Arrow
IPC分类号： A61F1300
CPC分类号： A01N57/16 , A61B17/06166 , A61B2017/00893 , A61K8/606 , A61K31/70 , A61L15/46 , A61L17/005 , A61L17/04 , A61L17/105 , A61L24/0015 , A61L24/106 , A61L27/54 , A61L27/60 , A61L2300/258 , A61L2300/404 , A61Q19/00
摘要： The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either on its surface, or integrated into the device. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule. The nucleic acids used in the invention are protonated/acidified to give a pH when dissolved in water of less than pH 7 to about 1, more preferably less than pH 4.5 to about 1, and even more preferably less than pH 2 to about 1.
摘要翻译： 本发明提供了用于管理局部损伤感染的装置和组合物，每个装置和组合物在其表面上含有质子化/酸化的核酸或整合到装置中。 这些修饰的核酸在不考虑细菌类的情况下作为杀菌剂和/或抑菌剂是有效的，因此当诊断困难时或当存在多种感染性生物时特别有用。 本发明的核酸的抗生素活性不依赖于核酸的特定序列或核酸分子的长度。 本发明中使用的核酸被质子化/酸化，当溶解在低于pH7至约1，更优选小于pH 4.5至约1，甚至更优选小于pH 2至约1的水中时产生pH。
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公开(公告)号：US08183361B2
公开(公告)日：2012-05-22
申请号：US11673509
申请日：2007-02-09
申请人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
发明人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要： The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
摘要翻译： 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。
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公开(公告)号：US20050107344A1
公开(公告)日：2005-05-19
申请号：US10937094
申请日：2004-09-08
申请人： Roderic Dale , Steven Gatton , Amy Arrow , Terry Thompson
发明人： Roderic Dale , Steven Gatton , Amy Arrow , Terry Thompson
IPC分类号： C07H19/10 , A01N57/12 , A01N57/16 , A61K9/70 , A61K31/66 , A61K31/6615 , A61K31/675 , A61K31/683 , A61K31/70 , A61K31/7024 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K48/00 , A61L2/16 , A61P17/00 , A61P17/02 , A61P31/04 , A61P31/10
CPC分类号： A61K31/66 , A01N57/12 , A01N57/16 , A61K9/0014 , A61K31/70
摘要： The present invention provides protonated compounds having antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi.
摘要翻译： 本发明提供具有抗微生物活性的质子化化合物。 本发明还提供包含本发明的质子化化合物的抗微生物组合物。 本发明的质子化化合物为细菌和机会真菌的抗性菌株提供有效的抗微生物活性。
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公开(公告)号：US06211349B1
公开(公告)日：2001-04-03
申请号：US09222009
申请日：1998-12-30
IPC分类号： C07H2102
摘要： The novel discovery that protonated nucleic acids inhibit bacterial growth is reported and methods for the preparation and therapeutic use of nuclease resistant and acid resistant protonated/acidified nucleic acids for administration to animals including man, to treat or prevent a bacterial infection are described.
摘要翻译： 报道质子化核酸抑制细菌生长的新发现，描述了用于制剂和治疗用途的核酸酶抗性和酸抗性的质子化/酸化核酸给予包括人在内的动物，用于治疗或预防细菌感染的方法。
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公开(公告)号：US06211162B1
公开(公告)日：2001-04-03
申请号：US09282824
申请日：1999-03-31
申请人： Roderic M. K. Dale , Steven L. Gatton , Amy Arrow
发明人： Roderic M. K. Dale , Steven L. Gatton , Amy Arrow
IPC分类号： A61K5100
摘要： The present invention provides a method of treating bacterial respiratory infections by pulmonary administration of protonated/acidified nucleic acids. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule.
摘要翻译： 本发明提供了一种通过肺施用质子化/酸化的核酸来治疗细菌性呼吸道感染的方法。 这些修饰的核酸在不考虑细菌类的情况下作为杀菌剂和/或抑菌剂是有效的，因此当诊断困难时或当存在多种感染性生物时特别有用。 本发明的核酸的抗生素活性不依赖于核酸的特定序列或核酸分子的长度。
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