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47 条记录 (耗时 0.043 秒)

    Polymerizable composition, process for producing cross linked polymers, and cross-linkable polymers
    12.
    发明授权
    Polymerizable composition, process for producing cross linked polymers, and cross-linkable polymers 失效
    可聚合组合物，交联聚合物的生产方法和可交联聚合物

    公开(公告)号：US06281307B1

    公开(公告)日：2001-08-28

    申请号：US08875529

    申请日：1997-07-31

    申请人： Andreas Mühlebach ,  Andreas Hafner ,  Paul Adriaan Van Der Schaaf

    发明人： Andreas Mühlebach ,  Andreas Hafner ,  Paul Adriaan Van Der Schaaf

    IPC分类号： C08F480

    CPC分类号： C08G18/6204 ,  B33Y70/00 ,  C08G61/00

    摘要： Composition comprising (a) catalytic amounts of a one-component catalyst for metathesis polymerization and (b) at least one polymer with strained cycloalkenylene radicals bonded in the polymer backbone, alone or as a mixture with strained cycloolefins. The composition can be polymerized thermally or photochemically by metathesis polymerization and is suitable for the production of shaped articles, coatings and relief images. The catalyst is selected from Ruthenium and Osmium compounds.

    摘要翻译： 组合物，其包含（a）催化量的用于复分解聚合的单组分催化剂和（b）至少一种具有结合在聚合物主链中的应变亚链烯基的聚合物，单独或作为与应变环烯烃的混合物。 组合物可以通过复分解聚合进行热或光化学聚合，并且适用于生产成形制品，涂层和浮雕图像。 催化剂选自钌和锇化合物。

    Process for the preparation of glycosides
    14.
    发明授权
    Process for the preparation of glycosides 失效
    糖苷的制备方法

    公开(公告)号：US5342929A

    公开(公告)日：1994-08-30

    申请号：US937818

    申请日：1992-08-31

    申请人： Beat Ernst ,  Michael Heneghan ,  Andreas Hafner

    发明人： Beat Ernst ,  Michael Heneghan ,  Andreas Hafner

    IPC分类号： B01J31/02 ,  B01J31/18 ,  B01J31/24 ,  C07B61/00 ,  C07H15/04 ,  C07H15/10 ,  C07H15/18 ,  C07H15/203 ,  C07H17/00

    CPC分类号： C07H15/04 ,  C07H15/10 ,  C07H15/18 ,  C07H15/203

    摘要： The invention relates to a process for the preparation of glycosides by reacting protected sugars carrying an anomeric hydroxyl group with an aglycon selected from the group consisting of alcohol, thiol and a protected sugar carrying a non-anomeric hydroxyl group, in an inert solvent, in the preferred temperature range from -20.degree. to +250.degree. C., in the presence of catalytic amounts of metal complex salts. The glycosides are obtained in high yield. Often an excess of the .alpha.- or .beta.-form is obtained and even the pure .alpha.- oder .beta.-forms are obtainable.

    摘要翻译： 本发明涉及一种制备糖苷的方法，该方法通过在惰性溶剂中，将惰性羟基的保护的糖与选自醇，硫醇和携带非端基异构羟基的被保护的糖的糖苷配基反应， 优选的温度范围为-20℃至+ 250℃，在催化量的金属络合盐存在下进行。 以高产率获得糖苷。 通常可以获得过量的α或β形式，甚至可以获得纯的α-β形式。

    Vehicle roof
    15.
    发明授权
    Vehicle roof 失效
    车顶

    公开(公告)号：US5002334A

    公开(公告)日：1991-03-26

    申请号：US349826

    申请日：1989-05-10

    申请人： Klaus Meiler ,  Hans Jardin ,  Andreas Hafner

    发明人： Klaus Meiler ,  Hans Jardin ,  Andreas Hafner

    IPC分类号： B60J7/00 ,  B60J7/08

    CPC分类号： B60J7/003

    摘要： Vehicle roof having a cover which, in a closed position, covers a roof opening in a fixed roof surface, and which can be extended above a fixed roof surface by pivotal movement about a pivotal axis which extends between its lateral edges. Below the cover, a cover liner is provided which, during upward extension of the cover, is bent about a center axis which is parallel to the pivotal axis of the cover. The liner, in a transversely extending center area, is provided with at least one cutout that extends transversely across a main portion of the liner and which reaches downwardly from the upper side of the liner, through a portion of the thickness of the liner sufficient to create a flexible hinge-like portion, thus permitting the liner to bend when the cover is extended. When the liner is in its unbent condition, the cutout has a cross-sectional shape that widens upwardly.

    摘要翻译： 具有盖的车顶，其处于关闭位置，覆盖固定屋顶表面中的屋顶开口，并且可以通过围绕其侧向边缘之间延伸的枢转轴线的枢转运动而在固定的屋顶表面上方延伸。 在盖的下面，提供一种盖衬套，其在盖的向上延伸期间围绕平行于盖的枢转轴线的中心轴弯曲。 衬里在横向延伸的中心区域中设置有至少一个切口，其横向延伸穿过衬套的主要部分并且从衬套的上侧向下延伸穿过衬垫的厚度的一部分，足以至 产生柔性的铰链状部分，从而允许衬套在盖延长时弯曲。 当衬垫处于其未弯曲状态时，切口具有向上变宽的横截面形状。

    SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS
    16.
    发明申请
    SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS 有权
    表面活性蛋白作为固体药物制剂的优点

    公开(公告)号：US20110268792A1

    公开(公告)日：2011-11-03

    申请号：US13130128

    申请日：2009-11-13

    申请人： Andreas Buthe ,  Andreas Hafner ,  Franz Kaufmann ,  Esther Gabor ,  Guido Meurer ,  Jürgen Eck ,  Gordon Bradley

    发明人： Andreas Buthe ,  Andreas Hafner ,  Franz Kaufmann ,  Esther Gabor ,  Guido Meurer ,  Jürgen Eck ,  Gordon Bradley

    IPC分类号： A61K9/48 ,  A61P39/00 ,  A61K9/16 ,  A61K9/02 ,  A61K9/00 ,  A61K9/38

    CPC分类号： A61K9/4891 ,  A61K9/0065 ,  A61K9/2063 ,  A61K9/2095 ,  A61K9/2873 ,  C07K14/37

    摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.

    摘要翻译： 本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。 提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。 在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如， 作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。 通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。 用于本发明目的的表面活性蛋白质可以从它们各自的天然来源中分离或者通过重组技术制备并在合适的宿主中表达。

    Process for the preparation of ketimines
    18.
    发明授权
    Process for the preparation of ketimines 失效
    酮亚胺的制备方法

    公开(公告)号：US06806386B1

    公开(公告)日：2004-10-19

    申请号：US10130198

    申请日：2002-05-14

    申请人： Marc Thommen ,  Andreas Hafner ,  Frédëric Brunner ,  Hans-Jörg Kirner ,  Roman Kolly

    发明人： Marc Thommen ,  Andreas Hafner ,  Frédëric Brunner ,  Hans-Jörg Kirner ,  Roman Kolly

    IPC分类号： C07C20900

    CPC分类号： C07C249/02 ,  C07C251/20

    摘要： The present invention relates to a process for the preparation of compounds of formula (1), in which R1, R2 and R3 independently of one another are hydrogen, halogen , trifluoromethyl of or C1-C4alkoxy, wherein a compound of formula (2), in which R1, R2 and R3 are as defined in formula (1), is reacted with methlyamine in the presence of a non-alcoholic solvent and, if desired, in the presence of a sulfonic acid catalyst to give the compound of formula (2) and, if desired, is subject to purification by recrystallization.

    摘要翻译： 本发明涉及制备式（1）化合物的方法，其中R 1，R 2和R 3彼此独立地是氢，卤素，或C 1 -C 4烷氧基的三氟甲基，其中式（2）的化合物， 其中R 1，R 2和R 3如式（1）中所定义）与甲胺在非醇溶剂存在下反应，如果需要，在磺酸催化剂的存在下反应得到式（2）的化合物 ），如果需要，通过重结晶进行纯化。

    Process for the preparation of ketimines
    19.
    发明授权
    Process for the preparation of ketimines 失效
    酮亚胺的制备方法

    公开(公告)号：US06693218B1

    公开(公告)日：2004-02-17

    申请号：US10130199

    申请日：2002-09-20

    申请人： Marc Thommen ,  Andreas Hafner ,  Roman Kolly ,  Hans-Jörg Kirner ,  Frédéric Brunner

    发明人： Marc Thommen ,  Andreas Hafner ,  Roman Kolly ,  Hans-Jörg Kirner ,  Frédéric Brunner

    IPC分类号： C07C24902

    CPC分类号： C07C249/02 ,  C07C251/20

    摘要： Described is a process for the preparation of compounds of formula (1a) which comprises reacting an isomeric mixture consisting of from 75 to 95% of compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, to form a sertraline-imine isomeric mixture consisting of from 75 to 95% of formula (1a) and from 5 to 25% of formula (1b)(A1), or reacting an isomeric mixture consisting of from 75 to 95% of a compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, using suitable methods of isolation to form an enriched sertraline-imine isomeric mixture, consisting of >99% of a compound of formula (1a) and

    摘要翻译： 描述了制备式（1a）化合物的方法，其包括将由75至95％的式（2a）化合物和5至25％的式（2b）化合物组成的异构体混合物与甲胺 在合适的溶剂中形成由75至95％的式（1a）和5至25％的式（1b）（A1）组成的舍曲林 - 亚胺异构体混合物，或将由75 至95％的式（2a）化合物和5至25％的式（2b）化合物与甲胺在合适的溶剂中，使用合适的分离方法形成富集的舍曲林 - 亚胺异构体混合物，其由 > 99％的式（1a）化合物和<1％式（1b）化合物（A2）的化合物; 然后根据反应路线（A1）或（A2）得到的舍曲林 - 亚胺异构体混合物在合适的溶剂中，按照式（Ⅰ）中式（Ⅰa）中R1，R2 和R 3各自独立地为氢，卤素，三氟甲基或C 1 -C 4烷氧基，式（1b），（2a​​）和（2b）如说明书中所定义。