公开(公告)号：US20120058989A1

公开(公告)日：2012-03-08

申请号：US13082269

申请日：2011-04-07

申请人： Allan S. Wagman ,  Heinz E. Moser ,  Glenn A. McEnroe ,  James B. Aggen ,  Martin S. Linsell ,  Adam A. Goldblum ,  John H. Griffin ,  Lloyd J. Simons ,  Thomas R. Belliotti ,  Christina R. Harris ,  Toni-Jo Poel ,  Michael J. Melnick ,  Ricky D. Gaston

发明人： Allan S. Wagman ,  Heinz E. Moser ,  Glenn A. McEnroe ,  James B. Aggen ,  Martin S. Linsell ,  Adam A. Goldblum ,  John H. Griffin ,  Lloyd J. Simons ,  Thomas R. Belliotti ,  Christina R. Harris ,  Toni-Jo Poel ,  Michael J. Melnick ,  Ricky D. Gaston

IPC分类号： A61K31/553 ,  A61P31/04 ,  C07D498/14 ,  C07D471/14 ,  A61K31/55 ,  A61K31/5517

CPC分类号： C07D471/14 ,  C07D498/14 ,  C07D513/14

摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括其立体异构体，药学上可接受的盐和前药，其中A，B，D，E，G，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：US07332471B2

公开(公告)日：2008-02-19

申请号：US11342729

申请日：2006-01-30

申请人： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel Marquess ,  Daniel D. Long ,  Jason P. Chinn ,  Matthew B. Nodwell ,  Edmund J. Moran ,  James B. Aggen

发明人： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel Marquess ,  Daniel D. Long ,  Jason P. Chinn ,  Matthew B. Nodwell ,  Edmund J. Moran ,  James B. Aggen

IPC分类号： A61K38/00 ,  A61K31/545

CPC分类号： C07D519/00 ,  A61K38/00 ,  C07D501/46 ,  C07K9/008

摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

公开(公告)号：US06967240B1

公开(公告)日：2005-11-22

申请号：US10070302

申请日：2000-09-06

申请人： Daniel R. Dietrich ,  Werner Fischer ,  A. Richard Chamberlin ,  James B. Aggen ,  Ian Garthwaite ,  Christopher O. Miles ,  Kathryn M. Ross ,  Neale R. Towers

发明人： Daniel R. Dietrich ,  Werner Fischer ,  A. Richard Chamberlin ,  James B. Aggen ,  Ian Garthwaite ,  Christopher O. Miles ,  Kathryn M. Ross ,  Neale R. Towers

IPC分类号： A61K39/00 ,  C07K1/22 ,  C07K7/56 ,  C07K14/195 ,  C07K16/12 ,  C07K17/02 ,  G01N33/577 ,  G01N33/68 ,  C07K17/08 ,  G01N33/545 ,  G01N30/01

CPC分类号： C07K14/195 ,  A61K39/00 ,  C07K7/56 ,  C07K16/12

摘要： The present invention relates to a protienaceous compound or functionally active derivative or part thereof having a binding site for a group represented by formula (I) which is part of a group of toxins derived from various cyanobacteria, to a method for its production, to diagnostic kits and to an affinty matrix (e.g. for use in immunoaffinity columns, online detection and purifications devices) containing the proteinaceous compound as well as to methods for substantially decreasing the amount of a compound containing the group represented by formula (I) in fluids or for concentrating compounds, e.g. toxins, containing the group represented by formula (I) from fluids such as crude water samples, extracts of algae or other tissue samples, e.g. to determine toxin concentrations.

摘要翻译： 本发明涉及具有由衍生自各种蓝细菌的一组毒素的一部分的式（I）表示的基团的结合位点的衍生物或其功能活性衍生物或其部分，其生产方法，诊断 试剂盒和含有蛋白质化合物的亲和基质（例如用于免疫亲和柱，在线检测和纯化装置）以及用于在流体中显着降低由式（I）表示的基团的化合物的量的方法或用于 浓缩化合物，例如 含有由式（I）表示的基团的毒素，例如粗水样品，藻类或其他组织样品的提取物，例如水溶液。 确定毒素浓度。

公开(公告)号：US07279458B2

公开(公告)日：2007-10-09

申请号：US11405331

申请日：2006-04-17

申请人： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel Marquess ,  Sean G. Trapp ,  Edmund J. Moran ,  James B. Aggen

发明人： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel Marquess ,  Sean G. Trapp ,  Edmund J. Moran ,  James B. Aggen

IPC分类号： A61K38/16 ,  C07K9/00 ,  C07K7/64 ,  C07K5/12 ,  A61K38/00 ,  A61K38/02 ,  A61K38/12 ,  A61K31/70

CPC分类号： C07K7/64 ,  C07D501/00 ,  C07K9/008

摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明提供可用作抗生素的交联糖肽 - 头孢菌素化合物及其药学上可接受的盐。 本发明还提供含有这些化合物的药物组合物; 使用这些化合物治疗哺乳动物细菌感染的方法; 以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US07067482B2

公开(公告)日：2006-06-27

申请号：US10888849

申请日：2004-07-09

申请人： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel Marquess ,  Sean G. Trapp ,  Edmund J. Moran ,  James B. Aggen

发明人： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel Marquess ,  Sean G. Trapp ,  Edmund J. Moran ,  James B. Aggen

IPC分类号： A61K38/16

CPC分类号： C07K7/64 ,  C07D501/00 ,  C07K9/008

摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

公开(公告)号：US07067481B2

公开(公告)日：2006-06-27

申请号：US10851428

申请日：2004-05-21

申请人： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel Marquess ,  Daniel D. Long ,  Jason P. Chinn ,  Matthew B. Nodwell ,  Edmund J. Moran ,  James B. Aggen

发明人： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel Marquess ,  Daniel D. Long ,  Jason P. Chinn ,  Matthew B. Nodwell ,  Edmund J. Moran ,  James B. Aggen

IPC分类号： A61K38/16

CPC分类号： C07D519/00 ,  A61K38/00 ,  C07D501/46 ,  C07K9/008

摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

公开(公告)号：US06653323B2

公开(公告)日：2003-11-25

申请号：US10292211

申请日：2002-11-12

申请人： Edmund J. Moran ,  John R. Jacobsen ,  James B. Aggen

发明人： Edmund J. Moran ,  John R. Jacobsen ,  James B. Aggen

IPC分类号： A61K3147

CPC分类号： C07D213/75 ,  C07C215/60 ,  C07C217/84 ,  C07C229/38 ,  C07C233/43 ,  C07D215/227 ,  C07D215/26 ,  C07D231/22 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D277/46 ,  C07D311/80 ,  C07D319/08 ,  C07D321/10 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12

摘要： The invention provides novel &bgr;2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with &bgr;2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明提供新颖的β2肾上腺素能受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与β2肾上腺素能受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。