公开(公告)号：US20200023363A1

公开(公告)日：2020-01-23

申请号：US16336353

申请日：2017-09-22

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers

IPC: B01L3/00 ,  B01L7/00 ,  C40B30/06 ,  G01N1/34 ,  G01N21/64 ,  G01N30/04 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G16B25/20 ,  G16B30/00 ,  G16B35/10

Abstract: Fluidic systems including cartridges comprising vessels, microfluidic channels and related methods for performing chemical and/or biological analyses are generally provided. The systems described herein include, according to certain embodiments, a cartridge comprising a vessel adapted and arranged to contain a fluid and/or reagent for performing a chemical and/or biological analysis. The vessel may be designed to have a particular shape or configuration, such as a tapered cross-sectional shape, e.g., to facilitate manipulation of a fluid and/or reagent within the vessel (e.g., a lyosphere).

公开(公告)号：US10450597B2

公开(公告)日：2019-10-22

申请号：US14605363

申请日：2015-01-26

Applicant: The General Hospital Corporation ,  ArcherDX, Inc.

Inventor： Anthony John Iafrate ,  Long Phi Le ,  Zongli Zheng ,  Jason Myers ,  Joshua Stahl

IPC: C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809

Abstract: Aspects of the technology disclosed herein relate to methods for preparing and analyzing nucleic acids. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.

公开(公告)号：US20190224675A1

公开(公告)日：2019-07-25

申请号：US16336342

申请日：2017-09-22

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers

IPC: B01L3/00 ,  G01N35/02 ,  C12Q1/686

Abstract: Fluidic systems including cartridges with modular components (cassettes) and/or microfluidic channels for performing chemical and/or biological analyses are provided. The systems described herein include a cartridge comprising, in some embodiments, a frame, one or more cassettes which may be inserted into the frame, and a channel system for transporting fluids. In certain embodiments, the one or more cassettes comprise one or more reservoirs or vessels configured to contain and/or receive a fluid (e.g., a stored reagent, a sample). In some cases, the stored reagent may include one or more lyospheres. The systems and methods described herein may be useful for performing chemical and/or biological reactions including polymerase chain reactions (PCR) such as those performed within a laboratory, clinical (e.g., hospital), or research setting.

公开(公告)号：US20190221289A1

公开(公告)日：2019-07-18

申请号：US16336344

申请日：2017-09-22

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers

IPC: G16B30/00 ,  G16B35/00 ,  G16B25/20 ,  C12Q1/68 ,  B01L3/00

CPC classification number: G16B30/00 ,  B01L3/502761 ,  B01L3/50825 ,  B01L7/52 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0644 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26 ,  C07H21/00 ,  C12Q1/68 ,  C12Q1/6806 ,  C40B30/06 ,  F04C14/14 ,  G01N1/34 ,  G01N30/04 ,  G01N30/6091 ,  G01N33/54326 ,  G01N35/0098 ,  G01N35/02 ,  G01N2030/8827 ,  G01N2035/00564 ,  G16B25/20 ,  G16B35/00 ,  C12Q2563/143 ,  C12Q2563/149

Abstract: Biological analysis system and methods for operating devices of the system are provided. A library preparation device of the biological analysis system may perform a library preparation protocol on a biological sample, where the library preparation protocol is determined based on information from an encoded identifier associated with the biological sample and a resource to be used by the library preparation device. A sequencing device may perform a sequencing process on a library prepared by the library preparation device. Configuration of the sequencing device to perform the process may include receiving sample information generated by the library preparation device and processing the sample information to generate configuration information for the sequencing device. Results from the sequencing process may be analyzed to determine nucleic acid sequences based on the sample information.

公开(公告)号：US20180155767A1

公开(公告)日：2018-06-07

申请号：US15802408

申请日：2017-11-02

Applicant: ArcherDX, Inc.

Inventor： Jason Myers ,  Joshua Stahl ,  Brady Culver ,  Brian Kudlow ,  Jens Eberlein

IPC: C12Q1/6813 ,  C07K16/28 ,  C12Q1/6806 ,  C12N15/09 ,  A61P35/02

CPC classification number: C12Q1/6813 ,  A61P35/02 ,  C07D495/04 ,  C07K16/2809 ,  C07K2319/32 ,  C12N15/09 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q2521/107 ,  C12Q2525/191 ,  C12Q2565/531

Abstract: Aspects of the technology disclosed herein relate to methods of preparing and analyzing nucleic acids, e.g., nucleic acids encoding immune receptors and immunoglobulins. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein

公开(公告)号：US20180127806A1

公开(公告)日：2018-05-10

申请号：US15706642

申请日：2017-09-15

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers ,  Brady Culver ,  Brian Kudlow

IPC: C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/6853 ,  C12N15/10

Abstract: Aspects of the technology disclosed herein relate to methods of preparing and analyzing nucleic acids. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.