公开(公告)号：US20190232289A1

公开(公告)日：2019-08-01

申请号：US16336322

申请日：2017-09-22

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers

IPC: B01L3/00 ,  G01N35/02

CPC classification number: B01L3/502738 ,  B01L3/502761 ,  B01L3/50825 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/02 ,  B01L2300/021 ,  B01L2300/041 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0644 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26 ,  C07H21/00 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/686 ,  C40B30/06 ,  F04C14/14 ,  G01N1/34 ,  G01N21/6428 ,  G01N30/04 ,  G01N30/6091 ,  G01N33/54326 ,  G01N35/00732 ,  G01N35/0098 ,  G01N35/02 ,  G01N35/026 ,  G01N2030/8827 ,  G01N2035/00564 ,  G01N2035/00752 ,  G16B25/20 ,  G16B30/00 ,  G16B35/00 ,  G16B35/10 ,  C12Q2563/143 ,  C12Q2563/149

Abstract: Fluidic systems including cartridges with modular components (cassettes) and/or microfluidic channels for performing chemical and/or biological analyses are provided. The systems described herein include a cartridge comprising, in some embodiments, a frame, one or more cassettes which may be inserted into the frame, and a channel system for transporting fluids. In certain embodiments, the one or more cassettes comprise one or more reservoirs or vessels configured to contain and/or receive a fluid (e.g., a stored reagent, a sample). In some cases, the stored reagent may include one or more lyospheres. The systems and methods described herein may be useful for performing chemical and/or biological reactions including polymerase chain reactions (PCR) such as those performed within a laboratory, clinical (e.g., hospital), or research setting.

公开(公告)号：US20210054435A1

公开(公告)日：2021-02-25

申请号：US16919238

申请日：2020-07-02

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers ,  Brady Culver ,  Brian Kudlow

IPC: C12Q1/6806 ,  C12N15/10 ,  C12Q1/6853 ,  C12Q1/6855

Abstract: Aspects of the technology disclosed herein relate to methods of preparing and analyzing nucleic acids. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.

公开(公告)号：US20210017571A1

公开(公告)日：2021-01-21

申请号：US16804695

申请日：2020-02-28

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers ,  Brady Culver ,  Brian Kudlow

IPC: C12Q1/6806 ,  C12N15/10 ,  C12Q1/6853 ,  C12Q1/6855

Abstract: Aspects of the technology disclosed herein relate to methods of preparing and analyzing nucleic acids, e.g, cfDNA. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.

公开(公告)号：US10704082B2

公开(公告)日：2020-07-07

申请号：US15706642

申请日：2017-09-15

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers ,  Brady Culver ,  Brian Kudlow

IPC: C12Q1/6806 ,  C12N15/10 ,  C12Q1/6853 ,  C12Q1/6855

Abstract: Aspects of the technology disclosed herein relate to methods of preparing and analyzing nucleic acids. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.

公开(公告)号：US10683531B2

公开(公告)日：2020-06-16

申请号：US15706649

申请日：2017-09-15

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers ,  Brady Culver ,  Brian Kudlow

IPC: C12Q1/6806 ,  C12N15/10 ,  C12Q1/6853 ,  C12Q1/6855

Abstract: Aspects of the technology disclosed herein relate to methods of preparing and analyzing nucleic acids, e.g, cfDNA. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.

公开(公告)号：US20180127807A1

公开(公告)日：2018-05-10

申请号：US15706649

申请日：2017-09-15

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers ,  Brady Culver ,  Brian Kudlow

IPC: C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/6853 ,  C12N15/10

Abstract: Aspects of the technology disclosed herein relate to methods of preparing and analyzing nucleic acids, e.g, cfDNA. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.

公开(公告)号：US20150211050A1

公开(公告)日：2015-07-30

申请号：US14605363

申请日：2015-01-26

Applicant: The General Hospital Corporation ,  ArcherDX, Inc.

Inventor： Anthony John Iafrate ,  Long Phi Le ,  Zongli Zheng ,  Jason Myers ,  Joshua Stahl

IPC: C12Q1/68

Abstract: Aspects of the technology disclosed herein relate to methods for preparing and analyzing nucleic acids. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.

Abstract translation: 本文公开的技术方面涉及制备和分析核酸的方法。 在一些实施方案中，本文提供了用于制备用于序列分析的核酸（例如，使用下一代测序）的方法。

公开(公告)号：US20200023363A1

公开(公告)日：2020-01-23

申请号：US16336353

申请日：2017-09-22

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers

IPC: B01L3/00 ,  B01L7/00 ,  C40B30/06 ,  G01N1/34 ,  G01N21/64 ,  G01N30/04 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G16B25/20 ,  G16B30/00 ,  G16B35/10

Abstract: Fluidic systems including cartridges comprising vessels, microfluidic channels and related methods for performing chemical and/or biological analyses are generally provided. The systems described herein include, according to certain embodiments, a cartridge comprising a vessel adapted and arranged to contain a fluid and/or reagent for performing a chemical and/or biological analysis. The vessel may be designed to have a particular shape or configuration, such as a tapered cross-sectional shape, e.g., to facilitate manipulation of a fluid and/or reagent within the vessel (e.g., a lyosphere).

公开(公告)号：US10450597B2

公开(公告)日：2019-10-22

申请号：US14605363

申请日：2015-01-26

Applicant: The General Hospital Corporation ,  ArcherDX, Inc.

Inventor： Anthony John Iafrate ,  Long Phi Le ,  Zongli Zheng ,  Jason Myers ,  Joshua Stahl

IPC: C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809

Abstract: Aspects of the technology disclosed herein relate to methods for preparing and analyzing nucleic acids. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) are provided herein.

公开(公告)号：US20190224675A1

公开(公告)日：2019-07-25

申请号：US16336342

申请日：2017-09-22

Applicant: ArcherDX, Inc.

Inventor： Joshua Stahl ,  Jason Myers

IPC: B01L3/00 ,  G01N35/02 ,  C12Q1/686

Abstract: Fluidic systems including cartridges with modular components (cassettes) and/or microfluidic channels for performing chemical and/or biological analyses are provided. The systems described herein include a cartridge comprising, in some embodiments, a frame, one or more cassettes which may be inserted into the frame, and a channel system for transporting fluids. In certain embodiments, the one or more cassettes comprise one or more reservoirs or vessels configured to contain and/or receive a fluid (e.g., a stored reagent, a sample). In some cases, the stored reagent may include one or more lyospheres. The systems and methods described herein may be useful for performing chemical and/or biological reactions including polymerase chain reactions (PCR) such as those performed within a laboratory, clinical (e.g., hospital), or research setting.