公开(公告)号：US06432050B1

公开(公告)日：2002-08-13

申请号：US09303644

申请日：1999-05-03

申请人： Yariv Porat ,  Avi Penner ,  Eyal Doron

发明人： Yariv Porat ,  Avi Penner ,  Eyal Doron

IPC分类号： A61B500

CPC分类号： A61B5/02158 ,  A61B5/0031 ,  A61B5/026 ,  A61B5/031 ,  A61B5/413 ,  A61B2562/028 ,  A61M2205/3523 ,  G01F1/36 ,  G01F1/72 ,  H01L41/1138 ,  H04R17/00

摘要： An implantable biosensor system for monitoring and optionally alleviating a physiological condition in a patient is provided and includes (a) at least one sensor for sensing at least one parameter of a physiological condition and for generating electrical sensor signals representative of the physiological condition; and (b) a first acoustic activatable transducer being directly or indirectly coupled with the at least one sensor, the first acoustic activatable transducer being for converting a received acoustic interrogation signal from outside the patient's body into an electrical power for energizing the processor, the first acoustic activatable transducer further being for converting the electrical sensor signals of the at least one sensor into acoustic signals receivable out of the patient's body, such that information pertaining to the at least one parameter of the physiological condition can be relayed outside the patient's body upon generation of an acoustic interrogation signal.

摘要翻译： 提供了一种用于监测和任选地减轻患者生理状况的植入式生物传感器系统，其包括（a）至少一个用于感测至少一个生理状态参数并用于产生代表生理状态的电传感器信号的传感器; 所述第一声学可激活换能器用于将接收到的来自患者身体外部的声学询问信号转换成用于激励所述处理器的电力，所述第一声学可激活换能器与所述至少一个传感器直接或间接耦合， 声学可激活的换能器还用于将至少一个传感器的电传感器信号转换成可从患者身体接收的声信号，使得与生理状况的至少一个参数相关的信息可以在生成后被中继到患者体外 的声讯讯号。

公开(公告)号：US06239724B1

公开(公告)日：2001-05-29

申请号：US09316397

申请日：1999-05-21

申请人： Eyal Doron ,  Yariv Porat ,  Avi Penner

发明人： Eyal Doron ,  Yariv Porat ,  Avi Penner

IPC分类号： G08C1912

CPC分类号： A61B5/0535 ,  A61B5/0031 ,  A61B5/413 ,  A61B2562/028 ,  A61N1/37288 ,  G01F1/36 ,  G01F1/72 ,  H01L41/1132 ,  H04R17/00 ,  Y10S128/903

摘要： A telemetry system and method for providing spatial positioning information from within a patient's body are disclosed. The system includes at least one implantable telemetry unit which includes (a) at least one first transducer being for converting a power signal received from outside the body, into electrical power for powering the at least one implantable telemetry unit; (b) at least one second transducer being for receiving a positioning field signal being received from outside the body; and (c) at least one third transducer being for transmitting a locating signal transmittable outside the body in response to the positioning field signal.

摘要翻译： 公开了一种用于从患者体内提供空间定位信息的遥测系统和方法。 该系统包括至少一个可植入遥测单元，其包括（a）用于将从身体外部接收的功率信号转换成用于为至少一个可植入遥测单元供电的电力的至少一个第一换能器; （b）至少一个第二换能器，用于接收从身体外部接收的定位场信号; 和（c）至少一个第三换能器，用于响应于所述定位场信号，传送可发射到身体外部的定位信号。

公开(公告)号：US08540631B2

公开(公告)日：2013-09-24

申请号：US11680529

申请日：2007-02-28

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61B5/07 ,  A61B5/02

CPC分类号： A61N1/37217 ,  A61B5/0008 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/4839 ,  A61B2017/00026 ,  A61B2560/0214 ,  A61B2560/0257 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/3507 ,  A61N1/37288 ,  A61N1/378 ,  G06F19/00

摘要： Systems and methods provide intrabody communication using acoustic telemetry. The system includes a first or control implant including a first acoustic transducer, and a second implant including a switch and a second acoustic transducer coupled to the switch. The second acoustic transducer receives acoustic signals from the first acoustic transducer for closing the switch to activate the second implant. The second implant may include a sensor for measuring a physiological parameter that is transmitted using acoustic signals including the physiological data to the first implant. For example, the second implant may measure pressure in the patient's heart that may be used by the first implant to control a pacemaker. Alternatively, the second implant may blood sugar concentration that may be used by the first implant to control an insulin pump. Alternatively, the first implant may store and transfer the data to an external device for monitoring the patient.

摘要翻译： 系统和方法使用声学遥测提供体内通信。 该系统包括包括第一声换能器的第一或控制植入物，以及包括开关和耦合到开关的第二声换能器的第二植入物。 第二声换能器接收来自第一声换能器的声信号，用于闭合开关以激活第二植入。 第二植入物可以包括用于测量使用包括生理数据的声学信号发送到第一植入物的生理参数的传感器。 例如，第二植入物可以测量患者心脏中可能被第一植入物用于控制起搏器的压力。 或者，第二植入物可以由第一植入物使用以控制胰岛素泵的血糖浓度。 或者，第一植入物可以将数据存储并传送到用于监测患者的外部设备。

公开(公告)号：US20070142728A1

公开(公告)日：2007-06-21

申请号：US11680529

申请日：2007-02-28

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61N1/37217 ,  A61B5/0008 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/4839 ,  A61B2017/00026 ,  A61B2560/0214 ,  A61B2560/0257 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/3507 ,  A61N1/37288 ,  A61N1/378 ,  G06F19/00

摘要： Systems and methods provide intrabody communication using acoustic telemetry. The system includes a first or control implant including a first acoustic transducer, and a second implant including a switch and a second acoustic transducer coupled to the switch. The second acoustic transducer receives acoustic signals from the first acoustic transducer for closing the switch to activate the second implant. The second implant may include a sensor for measuring a physiological parameter that is transmitted using acoustic signals including the physiological data to the first implant. For example, the second implant may measure pressure in the patient's heart that may be used by the first implant to control a pacemaker. Alternatively, the second implant may blood sugar concentration that may be used by the first implant to control an insulin pump. Alternatively, the first implant may store and transfer the data to an external device for monitoring the patient.

摘要翻译： 系统和方法使用声学遥测提供体内通信。 该系统包括包括第一声换能器的第一或控制植入物，以及包括开关和耦合到开关的第二声换能器的第二植入物。 第二声换能器接收来自第一声换能器的声信号，用于闭合开关以激活第二植入。 第二植入物可以包括用于测量使用包括生理数据的声学信号发送到第一植入物的生理参数的传感器。 例如，第二植入物可以测量患者心脏中可能被第一植入物用于控制起搏器的压力。 或者，第二植入物可以由第一植入物使用以控制胰岛素泵的血糖浓度。 或者，第一植入物可以将数据存储并传送到用于监测患者的外部设备。

公开(公告)号：US07198603B2

公开(公告)日：2007-04-03

申请号：US10413428

申请日：2003-04-14

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61B5/02 ,  A61N1/00

CPC分类号： A61N1/37217 ,  A61B5/0008 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/4839 ,  A61B2017/00026 ,  A61B2560/0214 ,  A61B2560/0257 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/3507 ,  A61N1/37288 ,  A61N1/378 ,  G06F19/00

摘要： Systems and methods provide intrabody communication using acoustic telemetry. The system includes a first or control implant including a first acoustic transducer, and a second implant including a switch and a second acoustic transducer coupled to the switch. The second acoustic transducer receives acoustic signals from the first acoustic transducer for closing the switch to activate the second implant. The second implant may include a sensor for measuring a physiological parameter that is transmitted using acoustic signals including the physiological data to the first implant. For example, the second implant may measure pressure in the patient's heart that may be used by the first implant to control a pacemaker. Alternatively, the second implant may blood sugar concentration that may be used by the first implant to control an insulin pump. Alternatively, the first implant may store and transfer the data to an external device for monitoring the patient.

摘要翻译： 系统和方法使用声学遥测提供体内通信。 该系统包括包括第一声换能器的第一或控制植入物，以及包括开关和耦合到开关的第二声换能器的第二植入物。 第二声换能器接收来自第一声换能器的声信号，用于闭合开关以激活第二植入。 第二植入物可以包括用于测量使用包括生理数据的声学信号发送到第一植入物的生理参数的传感器。 例如，第二植入物可以测量患者心脏中可能被第一植入物用于控制起搏器的压力。 或者，第二植入物可以由第一植入物使用以控制胰岛素泵的血糖浓度。 或者，第一植入物可以将数据存储并传送到用于监测患者的外部设备。

公开(公告)号：US20060142819A1

公开(公告)日：2006-06-29

申请号：US11276576

申请日：2006-03-06

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61N1/08

CPC分类号： A61N1/37217 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/1112 ,  A61B5/14539 ,  A61B5/4839 ,  A61B8/4281 ,  A61B8/4472 ,  A61B8/56 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0242 ,  A61B2560/0257 ,  A61B2560/0412 ,  A61B2562/028 ,  A61N1/08 ,  A61N1/37235 ,  A61N1/37252 ,  A61N1/3787 ,  Y10S128/903

摘要： Systems and methods for communicating with an implant within a patient's body using acoustic telemetry includes an external communications device attachable to the patient's skin. The device includes an acoustic transducer for transmitting acoustic signals into the patient's body and/or for receiving acoustic signals from the implant. The device includes a battery for providing electrical energy to operate the device, a processor for extracting data from acoustic signals received from the implant, and memory for storing the data. The device may include an interface for communicating with a recorder or computer, e.g., to transfer data from the implant and/or to receive instructions for controlling the implant. The device is secured to the patient's skin for controlling, monitoring, or otherwise communicating with the implant, while allowing the patient to remain mobile.

摘要翻译： 使用声学遥测与患者体内的植入物进行通信的系统和方法包括可附接到患者皮肤的外部通信装置。 该装置包括用于将声信号传送到患者体内和/或用于从植入物接收声信号的声换能器。 该装置包括用于提供电能以操作装置的电池，用于从从植入物接收的声信号中提取数据的处理器，以及用于存储数据的存储器。 该装置可以包括用于与记录器或计算机通信的接口，例如从植入物传送数据和/或接收用于控制植入物的指令。 该装置被固定到患者的皮肤上，用于控制，监测或以其他方式与植入物通信，同时允许患者保持移动。

公开(公告)号：US06431175B1

公开(公告)日：2002-08-13

申请号：US09305442

申请日：1999-05-06

申请人： Avi Penner ,  Yariv Porat ,  Eyal Doron

发明人： Avi Penner ,  Yariv Porat ,  Eyal Doron

IPC分类号： A61B1900

CPC分类号： H01L41/1132 ,  A61B5/0031 ,  A61B5/413 ,  A61B2562/028 ,  A61N1/37288 ,  A61N5/1048 ,  A61N5/1071 ,  A61N2005/1072 ,  H04R17/00

摘要： A system for monitoring, directing and controlling the dose of radiation in a medical procedure for irradiating a specific region of a patient's body. In its generic form, the system includes at least one sensor being implantable within, or in proximity to, the specific region of the patient's body, the at least one sensor being for sensing at least one parameter associated with the radiation. The system further includes a relaying device which is in communication with the sensor(s). The relaying device serves for relaying the information outside of the patient's body.

摘要翻译： 用于在用于照射患者身体的特定区域的医疗程序中监测，指导和控制辐射剂量的系统。 在其通用形式中，该系统包括可植入在患者身体的特定区域内或附近的至少一个传感器，所述至少一个传感器用于感测与辐射相关联的至少一个参数。 该系统还包括与传感器通信的中继设备。 中继装置用于将病人身体外的信息中继。

公开(公告)号：US07621905B2

公开(公告)日：2009-11-24

申请号：US10638405

申请日：2003-08-12

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61K9/22

CPC分类号： H01L41/04 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097

摘要： A device for controlled release of molecules is provided. The device including: (a) a device body having at least one reservoir therein for containing the molecules, the at least one reservoir being formed with a barrier impermeable to the molecules thereby preventing release thereof from the at least one reservoir; and (b) at least one acoustic transducer being attached to, or forming a part of, the device body, the at least one acoustic transducer being for converting an acoustic signal received thereby into an electrical signal, the electrical signal leading to barrier permeabilization and therefore release of the molecules from the at least one reservoir.

摘要翻译： 提供了用于控制释放分子的装置。 该装置包括：（a）装置本体，其中具有用于容纳分子的至少一个储存器，所述至少一个储存器形成有不可渗透到该分子的屏障，从而防止其从至少一个储存器的释放; 所述至少一个声换能器用于将由此接收的声信号转换为电信号，所述电信号导致屏障透化，并且（b）至少一个声换能器附接到所述装置主体或形成所述装置主体的一部分， 因此从至少一个储器释放分子。

公开(公告)号：US07617001B2

公开(公告)日：2009-11-10

申请号：US11276576

申请日：2006-03-06

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61N1/18

CPC分类号： A61N1/37217 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/1112 ,  A61B5/14539 ,  A61B5/4839 ,  A61B8/4281 ,  A61B8/4472 ,  A61B8/56 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0242 ,  A61B2560/0257 ,  A61B2560/0412 ,  A61B2562/028 ,  A61N1/08 ,  A61N1/37235 ,  A61N1/37252 ,  A61N1/3787 ,  Y10S128/903

摘要： Systems and methods for communicating with an implant within a patient's body using acoustic telemetry includes an external communications device attachable to the patient's skin. The device includes an acoustic transducer for transmitting acoustic signals into the patient's body and/or for receiving acoustic signals from the implant. The device includes a battery for providing electrical energy to operate the device, a processor for extracting data from acoustic signals received from the implant, and memory for storing the data. The device may include an interface for communicating with a recorder or computer, e.g., to transfer data from the implant and/or to receive instructions for controlling the implant. The device is secured to the patient's skin for controlling, monitoring, or otherwise communicating with the implant, while allowing the patient to remain mobile.

摘要翻译： 使用声学遥测与患者体内的植入物进行通信的系统和方法包括可附接到患者皮肤的外部通信装置。 该装置包括用于将声信号传送到患者体内和/或用于从植入物接收声信号的声换能器。 该装置包括用于提供电能以操作装置的电池，用于从从植入物接收的声信号中提取数据的处理器，以及用于存储数据的存储器。 该装置可以包括用于与记录器或计算机通信的接口，例如从植入物传送数据和/或接收用于控制植入物的指令。 该装置被固定到患者的皮肤上，用于控制，监测或以其他方式与植入物通信，同时允许患者保持移动。

公开(公告)号：US06764446B2

公开(公告)日：2004-07-20

申请号：US09888272

申请日：2001-06-21

申请人： Lone Wolinsky ,  Eyal Doron ,  Alon Ben-Yosefh ,  Avi Penner

发明人： Lone Wolinsky ,  Eyal Doron ,  Alon Ben-Yosefh ,  Avi Penner

IPC分类号： A61B504

CPC分类号： A61B5/0028 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/031 ,  A61B5/053 ,  A61B5/076 ,  A61B5/14539 ,  A61B2560/0219 ,  A61B2562/0247 ,  A61B2562/028 ,  A61N1/37217 ,  A61N1/3787 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0651

摘要： An implant includes a pressure sensor, a controller for acquiring pressure data from the sensor, and an acoustic transducer for converting energy between electrical energy and acoustic energy. A capacitor is coupled to the acoustic transducer for storing electrical energy converted by the transducer and/or for providing electrical energy to operate the implant. The acoustic transducer may operate alternatively or simultaneously as an energy exchanger or an acoustic transmitter. During use, the implant is implanted within a patient's body, and an external transducer transmits a first acoustic signal into the patient's body, to energize the capacitor. The implant then obtains pressure data, and transmits a second acoustic signal to the external transducer, the second acoustic signal including the pressure data.

摘要翻译： 植入物包括压力传感器，用于从传感器获取压力数据的控制器和用于在电能和声能之间转换能量的声换能器。 电容器耦合到声换能器，用于存储由换能器转换的电能和/或用于提供电能以操作植入物。 声换能器可以作为能量交换器或声发射器交替地或同时地操作。 在使用期间，将植入物植入患者体内，并且外部换能器将第一声信号传送到患者体内，以激励电容器。 然后，植入物获得压力数据，并将第二声学信号发送到外部换能器，第二声学信号包括压力数据。