公开(公告)号：US09834798B2

公开(公告)日：2017-12-05

申请号：US14423448

申请日：2013-09-03

Applicant: BASF SE

Inventor： Andrea Piatesi ,  Kai-Uwe Baldenius ,  Klaus Ditrich ,  Alois Kindler ,  Marta Zajaczkowski-Fischer ,  Ralf Boehling ,  Alwin Rehfinger

IPC: C12P7/64 ,  C12N9/88 ,  C07H21/04 ,  C07K1/00 ,  C07C51/235 ,  C07C51/373

CPC classification number: C12P7/6427 ,  C07C51/235 ,  C07C51/373 ,  C12P7/6409 ,  C12Y402/01053 ,  C07C59/147 ,  C07C55/20

Abstract: A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.

公开(公告)号：US09828617B2

公开(公告)日：2017-11-28

申请号：US14421872

申请日：2013-08-13

Applicant: BASF SE ,  Evolva SA

Inventor： Michael Naesby ,  Christophe Folly ,  Curt Aimé Friis Nielsen ,  Anaelle Hatsch ,  Markus Schwab ,  Oskar Zelder ,  Stefan Haefner ,  Hartwig Schroeder ,  Birgit Hoff ,  Andrea Molt ,  Klaus Ditrich ,  Michael Breuer ,  Holger Hartmann ,  Karsten Koerber

IPC: C12N15/53 ,  C12P17/12 ,  C12N9/02 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/18 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/10

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

公开(公告)号：US20170145451A1

公开(公告)日：2017-05-25

申请号：US15323515

申请日：2015-07-02

Applicant: BASF SE

Inventor： Kai-Uwe Baldenius ,  Michael Breuer ,  Klaus Ditrich ,  Vaidotas Navickas ,  Francesco Mutti ,  Tanja Knaus ,  Nicholas Turner

IPC: C12P13/00 ,  C12N9/04 ,  C12N9/06

CPC classification number: C12P13/001 ,  C12N9/0006 ,  C12N9/0016 ,  C12N9/0018 ,  C12Y101/01001 ,  C12Y104/01009 ,  C12Y104/0102

Abstract: The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes—i.e. an alcohol dehydrogenase and an amine dehydrogenase—operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.