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    PEF-TS EXPRESSION UNITS
    12.
    发明申请
    PEF-TS EXPRESSION UNITS 审中-公开
    PEF-TS表达单位

    公开(公告)号：US20140242704A1

    公开(公告)日：2014-08-28

    申请号：US14272781

    申请日：2014-05-08

    申请人： BASF SE

    发明人： Oskar Zelder ,  Corinna Klopprogge ,  Burkhard Kröger ,  Hartwig Schröder ,  Stefan Haefner

    IPC分类号： C12N15/63

    CPC分类号： C12N15/63 ,  C07K14/34 ,  C12N15/77 ,  C12P13/04

    摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。

    Novel Microbial Succinic Acid Producers and Purification of Succinic Acid
    16.
    发明申请
    Novel Microbial Succinic Acid Producers and Purification of Succinic Acid 审中-公开
    新型微生物琥珀酸生产商和琥珀酸的纯化

    公开(公告)号：US20140127764A1

    公开(公告)日：2014-05-08

    申请号：US14150206

    申请日：2014-01-08

    申请人： BASF SE

    发明人： Hartwig Schröder ,  Stefan Haefner ,  Gregory Von Abendroth ,  Rajan Hollmann ,  Aline Raddatz ,  Hansgeorg Ernst ,  Hans Gurski

    IPC分类号： C12P7/46

    CPC分类号： C12P7/46 ,  C12N1/32 ,  C12N9/1029 ,  C12R1/01 ,  C12Y203/01054

    摘要： The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.

    摘要翻译： 本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及 涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。 本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。

    Gene Cluster for Biosynthesis of Cornexistin and Hydroxycornexistin
    19.
    发明申请
    Gene Cluster for Biosynthesis of Cornexistin and Hydroxycornexistin 有权
    用于生物合成Cornexistin和羟基角质素的基因簇

    公开(公告)号：US20140141440A1

    公开(公告)日：2014-05-22

    申请号：US14084030

    申请日：2013-11-19

    申请人： BASF SE

    发明人： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schröder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingruber ,  Jakob Weber

    IPC分类号： C12P17/04

    CPC分类号： C12P17/04 ,  C12N15/52 ,  C12P7/50

    摘要： The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

    摘要翻译： 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。