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公开(公告)号:US11921101B2
公开(公告)日:2024-03-05
申请号:US17648887
申请日:2022-01-25
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei Chang , Chiung-Han Wang
IPC: G01N33/48 , G01N1/28 , G01N15/10 , G01N15/14 , G01N21/17 , G06T7/00 , G06T7/11 , G06T7/80 , G06T7/90 , H04N23/58 , H04N23/67 , G01N15/00 , H04N23/57
CPC classification number: G01N33/48 , G01N1/2806 , G01N15/1012 , G01N15/1429 , G01N15/1463 , G01N21/17 , G06T7/0014 , G06T7/11 , G06T7/80 , G06T7/90 , H04N23/58 , H04N23/67 , G01N2015/0065 , G01N2015/1075 , G01N2015/1486 , G01N2021/177 , G06T2207/30168 , H04N23/57
Abstract: Disclosed are calibration techniques that can be implemented by a device that conducts biological tests. In certain embodiments, the device for testing a biological specimen includes a receiving mechanism to receive a carrier, a camera module arranged to capture imagery of the carrier, and a processor. Some examples of the processor can detect a calibration mode trigger. In calibration mode, the processor can divide the captured imagery into segments and selectively perform one or more calibration procedures for each segment. Then, the processor records a calibration result for each segment.
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公开(公告)号:US11899007B2
公开(公告)日:2024-02-13
申请号:US17648901
申请日:2022-01-25
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei Chang , Chiung-Han Wang
IPC: G01N33/48 , G01N1/28 , G01N21/17 , G06T7/80 , G06T7/11 , G06T7/90 , G01N15/10 , G01N15/14 , G06T7/00 , H04N23/58 , H04N23/67 , G01N15/00 , H04N23/57
CPC classification number: G01N33/48 , G01N1/2806 , G01N15/1012 , G01N15/1429 , G01N15/1463 , G01N21/17 , G06T7/0014 , G06T7/11 , G06T7/80 , G06T7/90 , H04N23/58 , H04N23/67 , G01N2015/0065 , G01N2015/1075 , G01N2015/1486 , G01N2021/177 , G06T2207/30168 , H04N23/57
Abstract: Disclosed are verification techniques that can be implemented by a device that conducts biological tests to verify that the specimen holding area carries a valid biological specimen. In certain embodiments, the testing device includes a receiving mechanism to receive a carrier, and the carrier includes a holding area that is to carry or to be exposed to a biological specimen. The device can also include a camera module arranged to capture imagery of the carrier, and a processor. In some examples, the processor can capture the imagery of the carrier and identify a visual cue on the carrier. Then, the processor can verify, based on a manner of how the visual cue is displayed in the captured imagery, whether the holding area carries a valid biological specimen.
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公开(公告)号:US20240034990A1
公开(公告)日:2024-02-01
申请号:US18455458
申请日:2023-08-24
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , Fang-Zong Wang , Han-Yuan Gao
IPC: C12N5/071
CPC classification number: C12N5/0612
Abstract: A sperm sorting device suitable for selectively isolating a plurality of motile sperms from a semen specimen includes a base whose bottom wall and surrounding wall define a receiving space, and a sorter securely coupled to the base and including a mounting member and a sorting filter. The mounting member has a sleeve located in the receiving space and an injection portion located at the bottom end of the sleeve and having an injection hole. The sorting filter is fixed on the sleeve and, together with the injection portion and the sleeve, defines a sorting chamber with an open top end. The sorting filter, the bottom wall, and the surrounding wall define a specimen chamber for receiving the semen specimen. The injection hole brings the specimen chamber and the sorting chamber into communication vertically, so the semen specimen can be injected through the injection hole into the specimen chamber rapidly.
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公开(公告)号:US20230075204A1
公开(公告)日:2023-03-09
申请号:US18047242
申请日:2022-10-17
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , Li-Sheng Chang , Hsiu-Chin Lee
IPC: C12Q1/68 , C12Q1/6806 , G01N1/30 , G01N21/64
Abstract: Disclosed herein is a method for the detection of the presence of sperm DNA fragmentation in a semen sample. The method comprises a step of embedding the semen sample containing sperm cells in a gel comprising acrylamide, acrylic acid, methacrylic acid, N-isopropylacrylamide (NIPAM), alginate, or polyethylene glycol (PEG), to obtain a sperm cells-embedded gel. A kit for detecting sperm DNA fragmentation in a semen sample is also disclosed.
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公开(公告)号:US10324022B2
公开(公告)日:2019-06-18
申请号:US16101336
申请日:2018-08-10
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , Hsuan-Yu Huang , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei Chang
Abstract: Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 8.5 mm. The magnifying component has a linear magnification ratio of at least 1. Some embodiments further include a multi-camera configuration. These embodiments include a first camera module and a second camera module arranged to capture one or more images of the first holding area and the second holding area, respectively. The processor may perform different analytic processes on the captured images of different holding areas to determine an outcome with regard to the biological specimen.
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公开(公告)号:US09958658B2
公开(公告)日:2018-05-01
申请号:US15152470
申请日:2016-05-11
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , Hsuan-Yu Huang , Chih-Pin Chang , Kuang-Li Huang
IPC: G02B21/02 , G02B21/00 , G02B21/34 , G02B21/06 , G02B21/24 , G02B21/36 , G06T7/00 , G06T7/60 , G06T7/20
CPC classification number: G02B21/0008 , G02B21/34 , G02B21/362 , G06T7/0012 , G06T7/204 , G06T7/246 , G06T2207/10024 , G06T2207/30024 , G06T2207/30242
Abstract: Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 3 mm. The magnifying component has a magnification ratio of at least 30.
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公开(公告)号:US20230031283A1
公开(公告)日:2023-02-02
申请号:US17815484
申请日:2022-07-27
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , George Chengkang Hsu , Han-Yuan Gao
Abstract: A sperm sorting device suitable for selectively isolating motile sperms from a semen specimen includes a base and a sorting unit. The base comprises a central protruding block including a truncated cone-shaped surface, a bottom wall that surrounds the central protruding block, and an intermediate ring. The intermediate ring connects to the bottom wall via an inner wall surface. The sorting unit includes a sorting ring and a protruding ring. The sorting ring includes a central hole for a sorting filter that filters the semen specimen and is beveled at an angle that increases a permeable surface of the sorting filter. The protruding ring connects to the sorting ring via an inner sleeve surface. The sperm sorting device enhances sperm sorting quality by allowing the motile sperms to swim upward through the first sorting filter naturally.
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公开(公告)号:US10940479B2
公开(公告)日:2021-03-09
申请号:US15586289
申请日:2017-05-04
Applicant: BONRAYBIO CO., LTD.
Inventor: Hui-Ying Lee , Cheng-Teng Hsu , Yu-Chiao Chi , Kuang-Li Huang
Abstract: A collection bottle and a method for detecting a characteristic of a sample are provided. The collection bottle includes a body and a cover. The body of the collection bottle has an accommodating space. The cover of the collection bottle is removably assembled to the body of the collection bottle, and the cover includes a channel and a testing part. The channel of the collection bottle communicates the accommodating space and the outside environment. While the cover of the collection bottle is assembled to the body, the testing part extends toward the accommodating space.
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公开(公告)号:US20210025865A1
公开(公告)日:2021-01-28
申请号:US17034433
申请日:2020-09-28
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei CHANG , Chiung-Han WANG
Abstract: Embodiments include a device for testing biological specimen. The device can include a receiving mechanism to receive a carrier. The carrier may include a holding area. The device may include a camera arranged to capture a plurality of images, including a first image and a second image, of the holding area. The device may include a positioning mechanism operable to adjust a relative location of the carrier to the camera. A processor in the device may utilize the camera module to: identify an edge of the first image; cause the positioning mechanism to adjust the relative location of the carrier to the camera in a manner such that, when the camera takes the second image, an edge of the second image aligns with the identified edge of the first image; and perform a set of analytic processes on a combined image from the first and second images.
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公开(公告)号:US10852290B2
公开(公告)日:2020-12-01
申请号:US16443699
申请日:2019-06-17
Applicant: Bonraybio Co., Ltd.
Inventor: Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei Chang , Chiung-Han Wang
Abstract: Embodiments disclose a device for testing biological specimen. The device includes a receiving mechanism to receive a carrier. The carrier includes a holding area that carries or has been exposed to the biological specimen. The device includes a camera module arranged to capture imagery of the holding area. The camera module includes an focusing motor operable to adjust a focal point of the camera. The device also includes a processor that is configured to utilize the camera module to determine, based on operations of the focusing motor, a volumetric property of the holding area and perform a set of analytic processes on at least a portion of the captured imagery of the holding area to determine one or more properties of the biological specimen.
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